The effect of pH of douching solutions on mucociliary clearance

Homer, Jarrod J; England, Ruth; Wilde, A. D.; Harwood, Graham; Stafford, Nick

doi:10.1046/j.1365-2273.1999.00265.x

Cited by 33 publications

(35 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In addition, alkaline pH proved to be more beneficial for ciliary function [24], and in vitro studies showed that the optimal ciliary beat frequency occurs between pH 6.9 and 9.5 [25]. It has been shown that BHS is superior to buffered normal saline in improving mucociliary clearance in adult patients with sinusitis [10,26].…”

Section: Discussionmentioning

confidence: 99%

Efficacy of Buffered Hypertonic Saline Nasal Irrigation for Nasal Symptoms in Children with Seasonal Allergic Rhinitis: A Randomized Controlled Trial

Malizia¹,

Fasola²,

Ferrante³

et al. 2017

Int Arch Allergy Immunol

View full text Add to dashboard Cite

Background: Saline nasal irrigation is labelled as an add-on treatment in patients with allergic rhinitis (AR). The primary aim of this study was to compare the efficacy of 21-day use of buffered hypertonic saline (BHS) versus normal saline solution (NSS) on reducing nasal symptoms in children with seasonal AR (SAR). Comparing their efficacy on nasal cytology counts (NCC), quality of life, and sleep quality was the secondary aim. Methods: In this 21-day,open-label, randomized controlled study, 36 SAR children (aged 6-13 years) with a Total 5 Symptom Score (T5SS) ≥5 received twice-daily BHS or NSS delivered through a nasal douche. Efficacy measures were least square mean changes (LSmc) in T5SS, NCC, Paediatric Rhinoconjunctivitis Quality of Life Questionnaire (PRQLQ), and Pittsburgh Sleep Quality Index (PSQI) scores. Results: BHS improved the T5SS total score to a greater extent than NSS (LSmc -6.45 vs. -5.45, p < 0.001). Concerning NCC, BHS significantly reduced the scores of neutrophils (LSmc -0.76, p = 0.004) and eosinophils (LSmc -0.46, p = 0.018), while NSS did not. Similarly, only BHS yielded a significant improvement in the PRQLQ score (LSmc -0.57, p = 0.009), whereas the improvement in PSQI score was comparable between the BHS (LSmc -0.77, p = 0.025) and NSS (LSmc -1.39, p < 0.001) groups. Overall, BHS was well tolerated. Conclusions: In children with SAR, BHS is effective in improving nasal symptoms and NCC, with an associated beneficial effect on quality of life.

show abstract

Section: Discussionmentioning

confidence: 99%

Efficacy of Buffered Hypertonic Saline Nasal Irrigation for Nasal Symptoms in Children with Seasonal Allergic Rhinitis: A Randomized Controlled Trial

Malizia¹,

Fasola²,

Ferrante³

et al. 2017

Int Arch Allergy Immunol

View full text Add to dashboard Cite

show abstract

“…Homer et al reported that saline solutions significantly shortened MCT. They also reported that it did this by altering the structural characteristics of mucus, rather than increasing the ciliary beat rate [13]. One study that used the saccharin test in patients with acute sinusitis compared pretreatment MC values with those after 3 weeks of treatment and reported that isotonic saline solution had no effect on nasal MC, but that hypertonic saline (3%) significantly shortened MCT [5].…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the effects on nasal mucociliary clearance of various nasal solutions applied topically in patients with sinusitis

Yasar¹,

Sutbeyaz²,

Sakat³

et al. 2017

Med-Science

View full text Add to dashboard Cite

Mucociliary clearance (MC) is one of the main defense mechanisms of the nasal respiratory mucosa. The purpose of this study was to determine changes occurring nasal MC in patients with sinusitis, and how medical treatment affects changes in MC, and to identify an appropriate topical solution with positive effects on MC for use in the treatment of sinusitis by examining the effects of various topical solutions on MC. 60 patients diagnosed with rhinosinusitis at the ear, nose and throat clinic were included in this prospective study. Patients were randomly assigned into groups. Group 1 (n:10) received no topical treatment. Group 2 (n:10) was administered with fluticasone propionate, Group 3 (n:10) received mometasone furoate and Group 4 (n:10) received oxymetazoline. Group 5 (n:10) received isotonic sea water for nasal irrigation, while Group 6 (n:10) received isotonic Ringer's solution for nasal irrigation. Group 7 represented the control group (non-sinusitis). The saccharin test was used to determine nasal mucociliary clearance times. The saccharin test was performed before and on the 2nd week of treatment in all groups. Basal MCT and 2nd week MCT values were compared in all groups. When measurements performed 20 min and 14 days after administration of topical agents were compared with basal values, mean MCT values at 20 min. and 14 days were shorter in all groups compared to mean basal MCT values. However, the difference between 20-min, 14th day and basal MCT values was only statistically significant in the oxymetazoline and isotonic Ringer's solution groups (p<0.05). We think that oxymetazoline and isotonic Ringer's solution can be used as supportive therapy in the treatment of sinusitis since these produce a significant shortening of MCT.

show abstract

“…This alkaline state may decrease mucous viscosity. Maximal ciliary beating frequency times have been shown to occur when the pH is between 7 and 9 (23), but other studies report that pH changes in normal subjects have been shown to have no effect on mucociliary clearance (24, 25). In synthesis, many studies imply, but do not directly confirm, a role for saline at various NaCl(OH) concentrations in rhinosinusitis.…”

Section: Methodsmentioning

confidence: 99%

Topical treatment of rhinosinusitis

Fiocchi

Sarratud

Bouygue

et al. 2007

Pediatric Allergy Immunology

View full text Add to dashboard Cite

We reviewed current clinical evidence for the use of topical treatments in pediatric rhinosinusitis. Repeated Entrez PubMed searches were done using the template algorithm [rhinosinusitis AND (...)] with the settings: [Humans; English; All Child 0-18; Clinical trial; Last 10 yr] for the following comparators: steroid, irrigation, saline, antihistamine, decongestant, antibiotic, antimycotic, fungicide. The authors' clinical experience in the pediatric allergy unit of a university hospital was also drawn upon. Pediatric studies were retrieved but only one satisfied current evidence-based medicine standards for reporting clinical trials. Studies could not be systematized because of methodological, analytical, and interpretation biases. While saline irrigation, nasal decongestants, steroids, antibiotics, antihistamines and fungicides are all in widespread pediatric use, comparing studies from the literature for evidence of efficacy implied subjective appraisal, except in the case of topical steroids. Evidence for the efficacy of topical treatment for pediatric rhinosinusitis is narrative albeit this modality cannot be excluded from individualized patient protocols on the basis of the clinical literature alone. With the exception of topical steroids, no weighable evidence of effectiveness supports the premise that topical treatments actually serve the purpose for which they are widely prescribed in pediatrics.

show abstract

The effect of pH of douching solutions on mucociliary clearance

Cited by 33 publications

References 21 publications

Efficacy of Buffered Hypertonic Saline Nasal Irrigation for Nasal Symptoms in Children with Seasonal Allergic Rhinitis: A Randomized Controlled Trial

Efficacy of Buffered Hypertonic Saline Nasal Irrigation for Nasal Symptoms in Children with Seasonal Allergic Rhinitis: A Randomized Controlled Trial

Evaluation of the effects on nasal mucociliary clearance of various nasal solutions applied topically in patients with sinusitis

Topical treatment of rhinosinusitis

Contact Info

Product

Resources

About