The Effect of Phenobarbital on Serum Hormone Levels and Their Diurnal Variations in Pregnancy

Luoma, P. V.; Heikkinen, Jouni; Ylöstalo, Pekka

doi:10.1159/000137964

Cited by 5 publications

(4 citation statements)

References 18 publications

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“…Similarly, in our patients (receiving PB and/or VPA), the elevation of mean basal PRL does not seem related to an AED effect. In fact, previous studies in normal women have never shown increased PRL levels after PB administration (Rosadini et al, 1983;Luoma et al, 1984), and VPA has been reported to blunt PRL levels in women (Melis et al, 1982(Melis et al, , 1984Giroud et al, 1985;Minervini et al, 1987).…”

Section: Time ( M I Dmentioning

confidence: 93%

Reproductive Endocrine Disorders in Women with Primary Generalized Epilepsy

et al. 1988

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It is known that women suffering from temporal lobe epilepsy may frequently present reproductive endocrine disorders (REDs). We hypothesized that a high occurrence of REDs could be found also in primary generalized epilepsy (PGE), and therefore investigated the hormonal and ovarian echographic profiles in 20 PGE female patients of reproductive age. Fourteen reported normal menstrual cycles, while 6 complained of longstanding menstrual irregularities. All but three patients were receiving antiepileptic drug (AED) therapy. In all subjects, the basal levels of gonadotropins, prolactin, and gonadal steroids were assayed. The response of luteinizing hormone (LH) to gonadotropin-releasing hormone was also investigated and ovarian ultrasonographic findings were evaluated. In five of six patients with menstrual problems (25% of the group), a well-defined RED was diagnosed (polycystic ovarian disease in three cases and hypothalamic ovarian failure in two). The 14 patients with normal menstrual cycles showed an elevation of mean basal follicle-stimulating hormone and prolactin, and a blunting of mean LH response. Our results suggest that a high occurrence of REDs may be found also in PGE. We hypothesize that a neurotransmitter dysfunction might be the common pathogenetic mechanism resulting in both REDs and PGE. The hormonal alterations observed in the patients with normal menstrual cycles seem to support our hypothesis. Previous data seem to rule out a possible AED effect accounting for the hormonal findings observed in our series. However, further studies are needed to confirm our preliminary results.

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Section: Time ( M I Dmentioning

confidence: 93%

Reproductive Endocrine Disorders in Women with Primary Generalized Epilepsy

et al. 1988

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“…Epilepsy PB PB + PHT PB + BDZ daily, did not significantly affect the serum levels of tion in a group of 18 normal pregnant women has PRL (Luoma et al, 1984).…”

Section: Sexmentioning

confidence: 77%

Prolactin Secretion in Epileptic Subjects Treated with Phenobarbital: Sex Differences and Circadian Periodicity

et al. 1986

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Circulating basal prolactin (PRL) levels were evaluated in 126 subjects of both sexes with partial or generalized epilepsy, who were treated with phenobarbital (PB) alone or in combination with either phenytoin or benzodiazepines. A significant increase in PRL levels was observed in male, but not in female, patients compared with a sex- and age-matched healthy volunteer group. Circadian PRL secretion, studied in six male epileptic patients on PB monotherapy and in nine normal subjects, showed comparable 24-h PRL mean values and a preserved PRL surge during the night in both groups; however, a statistically significant additional peak was found in male epileptic subjects during the late afternoon. The cosinor analysis of the data, used to evaluate PRL rhythmicity, showed a disruption of the 24-h periodicity in epileptic subjects, while the 12-h periodicity was maintained. These results indicate that central and/or peripheral mechanisms involved in PRL secretion control are more sensitive to PB alone or in combination with other antiepileptic drugs in male than in female subjects. However, the changes of PRL secretion we found were small and unrelated to the different clinical conditions.

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“…Unter der VPA-Therapie nahm die hGHAusschüttung nach L-DOPA-Einnahme in den Fällen signifikant ab, die vor der Therapie eine normale hGH-Freisetzung aufwiesen. GH-RH hatte unter VPA keinen signifikanten Einfluss [19,14]. Darüber hinaus fanden Prinz et al bei fünf gesunden männlichen Erwachsenen keinen Unterschied in der basalen und in der nächtlichen pulsatilen hGH-Freisetzung und zwar vor, unter und nach Absetzen der PB-Medikation (100 mg/Tag für 9 Tage).…”

Section: Introductionunclassified

Wachstumshormon und Antiepileptika

Kurlemann

Fiedler

2006

Z. Epileptol.

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The Effect of Phenobarbital on Serum Hormone Levels and Their Diurnal Variations in Pregnancy

Cited by 5 publications

References 18 publications

Reproductive Endocrine Disorders in Women with Primary Generalized Epilepsy

Reproductive Endocrine Disorders in Women with Primary Generalized Epilepsy

Prolactin Secretion in Epileptic Subjects Treated with Phenobarbital: Sex Differences and Circadian Periodicity

Wachstumshormon und Antiepileptika

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