The Effect of Phenylephrine Hydrochloride on the Miotic-Treated Eye*

Becker, Bernard; Gage, T.L.; Kolker, Allan E.

doi:10.1016/0002-9394(59)90735-4

Cited by 36 publications

(7 citation statements)

References 8 publications

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“…Meta-oxedrine will often release a minor alteration of the tension owing to a reduced production of aqueous humour. According to Becker et al (1959) the facility of outflow and the tension remain approximately unaltered in normal eyes after dilatation of the pupil with meta-oxedrine. In 16 glaucomatous eyes, on the other hand, a minor fall of the tension was noticed, whereas no alteration of the facility of outflow.…”

Section: Discussionmentioning

confidence: 99%

Pigment Liberation Test in Open‐angle Glaucoma

Kristensen

1968

Acta Ophthalmologica

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In 1921 Koelner described a patient with simple glaucoma, whose intraocular pressure rose 10 mm Hg on dilatation of the pupil. This patient had abundant pigment on the posterior surface of the cornea and the anterior surface of the iris. In 12 other patients with simple glaucoma mydriasis provoked by atropine, homatropine, or scopolamine involved no rise in pressure. Vogt (1925), among 12 patients with pseudo-exfoliation of the anterior lens capsule, found two in whom dilatation of the pupil released an excessive liberation of pigment floating in the aqueous humour. These patients suffered from glaucoma. No mention is made of the tension in relation to the appearance of pigment granules.Various workers, e. g. Bard (1934) and Pillat (1934) have since reported on such floaters in the aqueous humour following mydriasis. Pillat, using a stop watch, measured the velocity of movement of the pigment granules in the aqueous humour of patients with glaucoma and pseudo-exfoliation. A distance of 1 cm was covered in 75 seconds.We now know that even in normals mydriasis is often followed by presence of floaters in the aqueous humour. This may be of importance in the differential diagnosis from iritis. The mydriasis-induced floaters differ, however, completely in kind from those occurring in genuine iritis. The former consist in the main of fine, brownish, sometimes glossy, bronze-coloured pigment granules, whercas the latter are larger and greyish. These consist predominantly of mononuclear cells.In patients with open-angIe glaucoma, with or without pseudo-exfolation, such a mydriasis-induced pigment liberation may be excessive and sometimes be accompanied by an acute, transistory rise in pressure. This is a factor which seems to have attracted little attention, being mentioned in none of a series of reports on the influence of mydriatics on glaucomatous eyes and normal eyes. Rentz ( 1924) described the effect of subconjunctival adrenalin injection 586

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Section: Discussionmentioning

confidence: 99%

Pigment Liberation Test in Open‐angle Glaucoma

Kristensen

1968

Acta Ophthalmologica

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“…In the study by Shaw and Lewis[30] of 116 eyes, IOP rose ≥5 mmHg in 37 eyes (32%), actually fell in 34 eyes (29%), and remained unchanged or rose < 5 mmHg in 45 eyes (38%) after mydriasis with the combination of tropicamide and phenylephrine. The bi‐directional nature of the IOP response within a study population is documented by others, and the variation in its magnitude is reflected by high standard deviations about the mean[31,32,33,34,35,36,37,38,39]. Harris has also noted that the IOP response to a particular agent is not consistently reproducible in the same patient or eye[28].…”

Section: Risk Of Acute Glaucoma Following Mydriasismentioning

confidence: 99%

“…Several studies have shown that IOP may rise transiently following mydriasis in some eyes with chronic glaucoma by mechanisms not involving angle closure[28,29,30,31,32,33,34,35,36,37,38,39,40,41]. To put into context the degree of IOP rise represented in such studies, normal IOP is accepted as 11–21 mmHg (population mean 16 mmHg ± 2 sd ), and about 30% of normal eyes show a diurnal fluctuation of IOP of up to 5 mmHg.…”

Section: Risk Of Acute Glaucoma Following Mydriasismentioning

confidence: 99%

Mydriasis and glaucoma: exploding the myth. A systematic review

Pandit¹,

Taylor

2000

Diabetic Medicine

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“…Pretreatment with 2% pilocarpine, while not affecting the degree of dilatation, results in a reduction of the maximal pupil diameter by about 2-2.5 mm which is the amount of the miosis induced by pilocarpine. The net result is a pupil diameter that has a maximum of 5 versus 8 mm [10]. This finding becomes of particular importance when longi tudinal studies are performed.…”

Section: Discussionmentioning

confidence: 93%

Optimal Pupil Diameter for Scheimpflug Slit Image Photography of the Lens in Man

1992

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Densitometric analysis of Scheimpflug photography of the lens has been examined as a function of pupil diameter in normal volunteers. On the basis of both the length of the lens waveform and the integral area under the curve of the lens waveform, there is a critical pupil diameter above which the waveform is unchanged. Below this critical diameter the waveform becomes distorted by shortening and a change in shape. The critical pupil diameter is between 6 and 6.5 mm. This result is of importance either in longitudinal studies, where the pupil diameter may not be reproducible, or in studies where other drugs are used which may prevent full pupil dilatation.

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The Effect of Phenylephrine Hydrochloride on the Miotic-Treated Eye*

Cited by 36 publications

References 8 publications

Pigment Liberation Test in Open‐angle Glaucoma

Pigment Liberation Test in Open‐angle Glaucoma

Mydriasis and glaucoma: exploding the myth. A systematic review

Optimal Pupil Diameter for Scheimpflug Slit Image Photography of the Lens in Man

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