The effect of phospholipids on the lipolytic activity of heparin-induced plasma lipase

Lyophilized Silica Lipid Hybrid (SLH) Carriers for Poorly Water‐Soluble Drugs: Physicochemical and In Vitro Pharmaceutical Investigations

“…The presence of silica nanoparticles appears to prohibit this behavior possibly by providing a high surface area for fast lipase action and desorption of digestion products from the lipase site of action. Lecithin (used as surfactant for the SLH preparation), which is well known to act as a potent lipase inhibitor, also results in retarded rate and extent of lipolysis at the later stage of digestion . A previous study reported that pure Miglyol oil (in the absence of any lipase inhibitor) was almost completely digested at 60 min in a relatively slower rate compared with the spray‐dried SLH microparticles …”