The effect of photobiomodulation therapy on nonsurgical periodontal treatment in patients with type 2 diabetes mellitus: a randomized controlled, single-blind, split-mouth clinical trial

Özberk, Seda Sevinç; Gündoğar, Hasan; Özkaya, Mesut; Taner, İbrahim Levent; Ercıyas, Kamile

doi:10.1007/s10103-019-02897-z

Cited by 16 publications

(12 citation statements)

References 38 publications

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“…In order to clarify the effect of LiESWT therapy on SUI, we compared the pre-and post-treatment scores (W4 vs. W0, W8 vs W0, F1 vs W0) for intragroup of patients, not between groups of patients. Therefore, Paired t-test was used to perform a repeated measurement analysis for intragroup before/ after treatment and to calculate p-values for comparison 45,46 in single-arm clinical trial of the current study. For all statistical analyses, p < 0.05 was considered statistically significant.…”

Section: Discussionmentioning

confidence: 99%

Therapeutic effects of Low intensity extracorporeal low energy shock wave therapy (LiESWT) on stress urinary incontinence

Long

Lin

Chuang

et al. 2020

Sci Rep

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This study aimed to evaluate the therapeutic effects of Low intensity extracorporeal low energy shock wave therapy (LiESWT) on stress urinary incontinence (SUI). The investigation was a single-arm, openlabel, multicentre study conducted in Taiwan. 50 female patients with SUI received LiESWT-treated with 0.25 mJ/mm 2 intensity, 3000 pulses, and 3 pulses/second, once weekly for 4-weeks (W4) and 8-weeks (W8). The pad test, uroflowmetry, life quality questionnaires, and 3-day urinary diary measurement were performed before and after LiESWT intervention. The results revealed that 8-week of LiESWT treatment meaningfully improved urine leakage (pad test), maximum flow rate, post-voided residual urine, average urine volume, functional bladder capacity, urinary frequency, urgency symptom, and nocturia, which also persisted to show significant improvements at 1-month follow up (F1). Moreover, bothersome questionnaires scores were significantly improved at W4, W8, and F1 as compared to the baseline (W0). These results indicated that 8 weeks of LiESWT attenuated SUI symptoms on physical activity, reduced bladder leaks and overactive bladder (OAB), implying that LiESWT brought significant improvement in the quality of life. (ClinicalTrials.gov number, NCT04059133). Stress urinary incontinence (SUI) is a prevalent urologic problem that is characterized by involuntary leakage of urine upon physical activity, such as exercise, exertion, sneezing, coughing, and lifting heavy objects, leading to affect a woman's physical, psychological and social activity, and impact on her quality of life (QoL). SUI is a prevalent gyneco-urological problem worldwide, with an estimate as high as 40% in adult women with urethral sphincter deficiency 1,2. Vaginal delivery, aging, obesity, and menopause are some known risk factors. SUI also causes great psychosocial and sexual distress that is both costly in terms of health care expense and the QoL. Chong and colleagues reported that approximately 13.12 billion US dollars were spent on SUI, including sanitary pads, disposable underwear, diapers, laundry, dry cleaning, treatment and diagnosis 3. A spectrum of management modalities is currently available: lifestyle intervention and pelvic floor muscle training might be effective for mild symptom; electro-stimulation, vaginal devices and urethral inserts are non-invasive and temporary symptom-control methods; bulking agents and botulinum injections are less invasive with short-term effectiveness; mid-urethral slings and colposuspension are corrective with long-term effectiveness 4. Each of these methods has its strengths and limitations that should be chosen according to individual

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Section: Discussionmentioning

confidence: 99%

Therapeutic effects of Low intensity extracorporeal low energy shock wave therapy (LiESWT) on stress urinary incontinence

Long

Lin

Chuang

et al. 2020

Sci Rep

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“…In order to clarify the effect of LiESWT therapy on OAB, we compared the pre- and posttreatment scores (W4 vs. W0, W8 vs. W0, F1 vs. W0, and F3 vs. W0) for an intragroup of patients, not between groups of patients. Therefore, a paired t -test was used to perform a repeated measurement analysis for an intragroup before/after treatment and to calculate p values for comparison [ 32 , 33 ] in a single-arm clinical trial of the current study. For all statistical analyses, p < 0.05 was considered to be statistically significant.…”

Section: Methodsmentioning

confidence: 99%

Low-Intensity Extracorporeal Shock Wave Therapy Ameliorates the Overactive Bladder: A Prospective Pilot Study

Chuang

Lin

Chen

et al. 2020

BioMed Research International

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Objective. In the present clinical trial, we evaluated the therapeutic effects of low-intensity extracorporeal shockwave therapy (LiESWT) on overactive bladder (OAB). Methods. Female subjects with ages of 20-75 years and who have been clinically diagnosed with OAB were included in the study. The LiESWT (DUOLITH SD1 T-TOP, AG) applicator was placed on the suprapubic skin area and applied with an intensity of 0.25 mJ/mm2, 3000 pulses, and 3 pulses/second. To assess the therapeutic efficacy, all subjects were required to complete the validated OAB symptoms and life bothersome questionnaires, 3-day urinary diary, uroflowmetry, and post-voided residual urine (PVR) measurement at 4 weeks of LiESWT (W4), 8 weeks of LiESWT (W8), 1-month follow-up (F1), and 3-month follow-up (F3) after LiESWT. Result. 82 subjects with the mean age of 56.5±1.2 years were enrolled. The questionnaire scores were significantly improved at W4, W8, F1, and F3 as compared to baseline data (W0). At W8, the mean values of functional bladder capacity were meaningfully increased. According to the 3-day urinary diary, daytime frequency, urgency, and nocturia were significantly decreased. The uroflowmetry results showed that the mean voided urine volume and the maximal flow rate (Qmax) were noticeably increased. PVR volume was also significantly decreased. Conclusions. The data demonstrated that 8-week LiESWT ameliorated the OAB symptoms, promoted the uroflow parameters, and improved the quality of life (QoL) in OAB patients, suggesting that LiESWT might serve as an alternative noninvasive therapy for OAB.

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“…These articles were evaluated based on the eligibility criteria of the review. Additional studies were excluded due to the following reasons: an inappropriate study design or article type in 9 studies (15,16,21–27), LLLT utilized, as an adjunct to a surgical intervention or in the supportive periodontal therapy phase in 3 studies (28–30), in vitro or in vivo animal studies utilized in 3 papers (31–33), participants with systemic diseases recruited in 3 studies (34–39), no utilization of PBM in 11 studies (40–50), and LLLT utilized either; as a mono‐therapeutic agent or in combination with aPDT in 3 studies (51–53) (inter‐reviewer agreement, κ = 1). Hence, out of 52 full text articles, 35 articles were excluded, due to the abovementioned reasons, while the remaining 17 articles were included and analyzed in the present systematic review.…”

Section: Resultsmentioning

confidence: 99%

Effectiveness of Photobiomodulation as an Adjunct to Nonsurgical Periodontal Therapy in the Management of Periodontitis‐ A Systematic Review of in vivo Human Studies

Dalvi

Benedicenti

Hanna

2020

Photochem & Photobiology

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Photobiomodulation therapy (PBMT) has anti‐inflammatory, analgesic and regenerative properties. This systematic review aimed to critically appraise the published data of in vivo human randomized clinical trials (RCTs), and present a comprehensive overview of the efficacy of PBMT, as an adjunct to the nonsurgical periodontal therapy (NSPT) in the management of periodontitis. The systematic review protocol is registered in the Prospective Register Of Systematic Reviews (PROSPERO) (http://www.crd.york.ac.uk/PROSPERO/; ref CRD 42020169108). With the help of the appropriate key words, structured electronic and manual search strategies were applied to gather the relevant published data on in vivo human RCTs based on this topic. Seventeen papers that met the eligibility criteria were included in this review and subjected to a qualitative assessment. Current evidence lacks adequate information regarding the photobiomodulation (PBM) dosimetry, which is fundamental in establishing a standardized and replicable protocol for future researches. Furthermore, substantial discrepancies in the study methodology and a high risk of bias, arising from the majority of the included papers, abet to the inferior quality of these studies. Ultimately, there is an urgent necessity to conduct further well‐designed RCTs in order to determine the effectiveness of PBMT, if any, by taking into consideration the abovementioned confounding factors.

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The effect of photobiomodulation therapy on nonsurgical periodontal treatment in patients with type 2 diabetes mellitus: a randomized controlled, single-blind, split-mouth clinical trial

Cited by 16 publications

References 38 publications

Therapeutic effects of Low intensity extracorporeal low energy shock wave therapy (LiESWT) on stress urinary incontinence

Therapeutic effects of Low intensity extracorporeal low energy shock wave therapy (LiESWT) on stress urinary incontinence

Low-Intensity Extracorporeal Shock Wave Therapy Ameliorates the Overactive Bladder: A Prospective Pilot Study

Effectiveness of Photobiomodulation as an Adjunct to Nonsurgical Periodontal Therapy in the Management of Periodontitis‐ A Systematic Review of in vivo Human Studies

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