2001
DOI: 10.1006/exer.2000.0924
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The Effect of Photodynamic Therapy with Bacteriochlorin a on Lens Epithelial Cells in a Capsular Bag Model

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Cited by 33 publications
(30 citation statements)
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“…Recently, PDT with bacteriochlorin a effectively decreased PCO in vitro in a human capsular bag model [4]. Because our study used an in vivo model, we were able to provide further information on the issues which the previous in vitro study could not address.…”
Section: Discussionmentioning
confidence: 67%
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“…Recently, PDT with bacteriochlorin a effectively decreased PCO in vitro in a human capsular bag model [4]. Because our study used an in vivo model, we were able to provide further information on the issues which the previous in vitro study could not address.…”
Section: Discussionmentioning
confidence: 67%
“…PCO is caused by the proliferation and migration of lens epithelial cells (LECs) remaining in the capsular bag after cataract surgery [2,3]. Therefore, one of the approaches to prevent postoperative proliferation of LECs is to kill these cells in the capsular bag during surgery [4]. Applying antimetabolites into the capsular bag during phacoemulsification seems to be an effective way of eliminating LECs, but the safety of the drug remaining in the bag and its possible antimetabolic effect on adjacent tissues form a problem for clinical application [5][6][7][8][9].…”
Section: Introductionmentioning
confidence: 99%
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“…[1][2][3][4] The basic principle of PDT for cancer is the combination of a photosensitizing drug capable of absorbing within the body's therapeutic window ( ¼ 620{850 nm), a light source (e.g., a laser) of an appropriate wavelength and molecular oxygen. The photosensitizer, which accumulates preferentially in cancer cells and has a low dark toxicity, is injected into human body tissue and then irradiated with visible light.…”
Section: Introductionmentioning
confidence: 99%
“…In a previous study, it was observed that PDT with BCA is able to induce cell death in LECs in vitro [20]. For these experiments, a human lens capsular bag culture system was used, as designed by Liu et al [21].…”
Section: Introductionmentioning
confidence: 99%