The Effect of Phototherapy on Renal Blood Flow Velocity in Preterm Infants

Benders, Manon J. N. L.; Bel, Frank van; Bor, Margot van de

doi:10.1159/000013981

Cited by 23 publications

(12 citation statements)

References 18 publications

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“…Therefore, it is possible that phototherapy induces a reduction of left ventricular output, and the increase of CBFV is caused by the redistribution of blood flow to the organs. This seems to be confirmed by the reported lack of postprandial response of the intestinal blood flow [18,25] and by the decrease of renal blood flow [4] during phototherapy. On the contrary, LPT, which, in our study, shows the same efficacy versus CPT in reducing bilirubin levels in preterm infants with jaundice, does not induce changes in TEWL and in cerebral hemodynamics as a consequence of the minimal dose of visible light >530 nm and infrared ray irradiance.…”

Section: Discussionsupporting

confidence: 59%

Transepidermal water loss and cerebral hemodynamics in preterm infants: conventional versus LED phototherapy

et al. 2007

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The aim of our study was to evaluate whether high-intensity gallium nitride light-emitting diode (LED) phototherapy (LPT) influences transepidermal water loss (TEWL) and cerebral hemodynamics in preterm neonates in comparison with conventional phototherapy (CPT). Thirty-one preterm infants were randomized for conventional (n = 14) and for LED (n = 17) phototherapy. All infants were studied using a Tewameter TM 210 and cerebral Doppler ultrasound immediately before phototherapy (time 0), 30 min (time 1), 1-6 h (time 2), and 12-24 h (time 3) after the start of phototherapy, and 6-12 h after discontinuing phototherapy (time 4). The study shows that LPT does not induce significant changes in TEWL (time 0: 2.75 +/- 4.71 ml/m(2)/h; time 3: 14.45 +/- 3.68 ml/m(2)/h), in peak systolic, end diastolic and mean cerebral blood flow velocity (CBFV), and in the resistence index (RI). On the contrary, CPT is associated with a significant increase of TEWL (time 0: 13.22 +/- 5.61 ml/m(2)/h; time 3: 20.94 +/- 3.21 ml/m(2)/h), which disappeared at time 4, when phototherapy had stopped. The peak systolic and mean CBFV increased, respectively, from 0.11 +/- 0.03 m/s at time 0 to 0.16 +/- 0.07 m/s at time 3. We conclude that LPT, emitting light within the 450-470-nm spectrum for optimal bilirubin degradation, can be preferable to CPT for the therapy of hyperbilirubinemia in preterm infants.

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Section: Discussionsupporting

confidence: 59%

Transepidermal water loss and cerebral hemodynamics in preterm infants: conventional versus LED phototherapy

et al. 2007

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“…However, haemodynamic side effects have been reported. An increase in peripheral blood flow (Oh et al 1973, Wu et al 1974) and a decrease in cardiac output (Walther et al 1985, Benders et al 1999a), postprandial intestinal blood flow response (Yao et al 1994, Pezzati et al 2000, and renal blood flow velocity (Benders et al 1998a) have been described in infants during phototherapy. Moreover, a higher incidence of patent ductus arteriosus (Rosenfield et al 1986, Barefield et al 1993) and a re-opening of the ductus arteriosus (Benders et al 1998a(Benders et al , b, 1999a have been reported in infants treated with phototherapy.…”

mentioning

confidence: 99%

Effects of phototherapy on cerebral haemodynamics in preterm infants: is fibre‐optic different from conventional phototherapy?

Dani

Bertini

Martelli

et al. 2004

Develop Med Child Neuro

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We hypothesized that conventional phototherapy (CPT) and fibre‐optic phototherapy (FPT) could exert different effects on cerebral blood perfusion. Our aim was to assess this hypothesis in a prospective study of the cerebral haemodynamics in preterm infants. Twenty‐three infants (gestational age <34 weeks) were randomized for CPT (n=12) and for FPT (n=11). Cerebral Doppler ultrasounds were performed on all infants immediately before phototherapy (time 0), 6–12 hours (time 1) and 24–36 hours (time 2) after the start of phototherapy, and 6–12 hours after discontinuing phototherapy (time 3). CPT and FPT were associated with a significant increase of peak‐systolic blood flow velocity and mean blood flow velocity at time 1 and 2, which disappeared at time 3, whereas end‐diastolic blood flow velocity and resistance index were unchanged. No difference was shown between the groups. CPT and FPT were found to exert similar effects on cerebral haemodynamics. Both were associated with an increase of cerebral blood flow velocity which ended when phototherapy was stopped.

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“…Hypertensive disease during pregnancy,17 non-steroidal anti-inflammatory drugs,18 19 ACE inhibitors,20 magnesium sulphate21 or antibiotics18 administered to the mother, and intrapartum asphyxia22 are the most common antenatal risk factors described. The range of postnatal risk factors is as broad as low GA and very low birth weight,4 23 small-for GA (SGA),24 respiratory distress syndrome,18 low Apgar score,18 22 arterial hypotension and hypovolaemia,6 phototherapy in ventilated infants,25 early onset infection,17 septicaemia,6 congenital anomalies of the kidney and urinary tract,33 and drugs (Cox-inhibitors infused6 9 12 18 24 26 or oral)27 and antibiotics 7 8 18…”

Section: Discussionmentioning

confidence: 99%