The effect of piroctone olamine on reproduction of male and female rats

ALLGOOD, G

doi:10.1016/0272-0590(91)90132-n

Cited by 1 publication

(1 citation statement)

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“…Studies with mice, rats and dogs have shown that the PO has low toxicity. Research with animals has not shown any chromosomal abnormalities or acute pharmacological effects on the central nervous, cardiovascular or reproductive system or on other specific metabolic functions (Kim et al 2011 ; Allgood et al 1991 ).…”

Section: Resultsmentioning

confidence: 99%

Antifungal activity of the piroctone olamine in experimental intra-abdominal candidiasis

Couto¹,

Nascimento²,

Júnior³

et al. 2016

SpringerPlus

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This work aimed to evaluate the antifungal activity of piroctone olamine in the treatment of intra-abdominal candidiasis in an experimental model using Swiss mice. The mice (n = 6) were infected by intraperitoneal injection of 0.2 ml of C. albicans (107cells/ml in saline). The animals were observed daily for clinical signs and mortality for 14 days. The treatment with piroctone olamine (0.5 mg/kg) was performed 72 h after infection by intraperitoneal administration. For comparison, a group of animals (n = 6) was treated with amphotericin B (0.5 mg/kg). The mycological diagnosis was made by collecting the liver, spleen and kidneys. Data regarding the fungal growth and mortality were analyzed statistically by Student’s t test and analysis of variance (ANOVA), with level of significance set at P < 0.05. The difference in fungal growth scoring between the control group and the treatment groups (piroctone olamine and amphotericin B) was statistically significant (P < 0.05). The difference in fungal growth scoring between the treatment groups (piroctone olamine and amphotericin B) was not statistically significant (P < 0.05).

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Section: Resultsmentioning

confidence: 99%