The effect of piroxicam on post-operation analgesia when is used pre-procedure on urology patients

Gani, H.; Kerci, M.; Ohri, I.; Naco, Majlinda; Beqiri, V.

doi:10.1097/00003643-201106001-00667

Cited by 2 publications

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“…It has antipyretic, analgesic and anti‐inflammatory properties and the ability to reduce pain from different arthritic conditions and treat post‐operative inflammation . Similarly, the administration of PRX to patients subjected to laparoscopic surgery reduced post‐operative pain …”

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confidence: 99%

Simultaneous determination of piroxicam and norfloxacin in biological fluids by high‐performance liquid chromatography with fluorescence detection at zero‐order emission mode

et al. 2019

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A new highly sensitive high-performance liquid chromatographic method with fluorescence detection (HPLC-FLD) in zero-order emission mode was developed for the first time for the simultaneous determination of piroxicam (PRX) and norfloxacin (NRF) in biological fluids. The fluorescence detector wavelengths were set at 278 nm for excitation and zero-order mode for emission. The zero-order emission mode produced greater sensitivity for the measurement of both drugs than a fixed emission wavelength (446 nm). The new developed method was validated according to International Conference of Harmonization (ICH) guidelines. Linearity was found to be over concentration ranges 0.001-20 μg/ml and 0.00003-0.035 μg/ml for PRX and NRF, respectively. The limits of detection were 4.87 × 10 −4 and 1.32 × 10 −5 μg/ml for PRX and NRF, and the limits of quantitation were 1.47 × 10 −3 and 4.01 × 10 −5 μg/ml, respectively. The current fluorescence method was found to be more sensitive than most commonly used analytical methods and was successfully applied for simultaneous determination of PRX and NRF in biological fluids (serum and urine) with recoveries ranging from 91.67% to 100.36% for PRX and from 96.00% to 101.43% for NRF.

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Section: Introductionmentioning

confidence: 99%

Simultaneous determination of piroxicam and norfloxacin in biological fluids by high‐performance liquid chromatography with fluorescence detection at zero‐order emission mode

et al. 2019

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“…Formula structure of metformin hydrochloride2.2.2.2 PiroxicamPiroxicam is a non-steroidal anti-inflammatory drug (NSAID) of the oxicam class used to relieve postoperative pain, tenderness, swelling and stiffness caused by rheumatoid and osteoarthritis (arthritis caused by a breakdown of the lining of the joints), primary dysmenorrhea (menstrual cramps); and act as a painkiller, especially where there is an inflammatory component[94][95][96]. According to BCS, piroxicam is a class II drug (low solubility-high permeability) which has a high log P of 3.6 with water solubility of 23 mg/l, making it highly hydrophobic, and also having a half-life of approximately 37.5 hours[94,97].…”

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confidence: 99%

Multi-drug-loaded gastric-floating microcapsules

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The effect of piroxicam on post-operation analgesia when is used pre-procedure on urology patients

Cited by 2 publications

References 0 publications

Simultaneous determination of piroxicam and norfloxacin in biological fluids by high‐performance liquid chromatography with fluorescence detection at zero‐order emission mode

Simultaneous determination of piroxicam and norfloxacin in biological fluids by high‐performance liquid chromatography with fluorescence detection at zero‐order emission mode

Multi-drug-loaded gastric-floating microcapsules

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