The Effect of Pituitary Preparations on the Nitrogen Metabolism*

The Mechanism of the Action of Iodides on the Nitrogen Metabolism

“…The fluid intake and urine output were both maintained on a constant level throughout these experiments. 4. It seems likely that this increase in nitrogen excretion without a corresponding increase in sulphur excretion represents a mobilization and excretion of "deposit nitrogen.…”

“…It has been further shown that this increase does not change the nitrogen partition (5). It has been shown that the administration of sodium iodide for three days is accompanied by an immediate increase of 15 per cent in the nitrogen excretion in the urine, coinciding with the period of drug administration.…”

“…The increase of nitrogen excretion following the injection of sodium iodide did not occur after the removal of the thyroid gland in two dogs. 6. It seems evident that the presence of the thyroid gland is necessary for the mobilization and excretion of this nitrogen following the administration of iodides.…”

Studies on the Nitrogen and Sulphur Metabolism in “Bright's Disease”

“…This led us to search the other records for evidence of a similar condition, and we have been able to find in every patient with chronic nephritis without renal edema, periods of actual negative sulphur balance, taking into account the urine alone. In many experiments on normals, the protocols of some of which are available in another publication (1), no such negative balance even for one day was ever encountered. In a patient studied later, we happened to find a period of transition from positive to negative sulphur balance.…”