The effect of plant polyphenols on the antioxidant defence system of weaned piglets subjected to an &lt;i&gt;Escherichia coli&lt;/i&gt; challenge

Jiang, Xianren; Zhang, H. J.; Mantovani, G.; Alborali, G. L.; Caputo, J.M.; Savoini, G.; Dell’Orto, V.; Bontempo, V.

doi:10.22358/jafs/65668/2014

Cited by 14 publications

(11 citation statements)

References 38 publications

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“…However, the content of MDA had no difference between the HEM and CON groups. Plant extracts with antioxidant capacity have been widely used in both medicine and livestock production ( Jiang et al, 2014 ; Chen J. S. et al, 2019 ). For example, Jiang et al (2014) reported that dietary supplementation with plant polyphenols (apples, grape seeds, green teas, and olive leaves) has the tendency to enhance the activities of plasma GSH-PX (day 25) and T-AOC (day 27) in the weaning piglets challenged with Escherichia coli .…”

Section: Discussionmentioning

confidence: 99%

“…Plant extracts with antioxidant capacity have been widely used in both medicine and livestock production ( Jiang et al, 2014 ; Chen J. S. et al, 2019 ). For example, Jiang et al (2014) reported that dietary supplementation with plant polyphenols (apples, grape seeds, green teas, and olive leaves) has the tendency to enhance the activities of plasma GSH-PX (day 25) and T-AOC (day 27) in the weaning piglets challenged with Escherichia coli . A study showed that dietary supplementation with Lycium barbarum polysaccharides increases the activities of SOD, CAT, and GSH-PX and decreases the content of MDA in the serum and liver of weaning piglets ( Chen J. S. et al, 2019 ).…”

Section: Discussionmentioning

confidence: 99%

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Herbal Extract Mixture Modulates Intestinal Antioxidative Capacity and Microbiota in Weaning Piglets

et al. 2021

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Recently, herbal extracts have been applied in multiple aspects, such as medicine and animal feed. Different compositions of herbal extract mixture (HEM) have various components and diverse functions. This study aimed to evaluate the effects of HEM (Lonicera japonica, Astragalus membranaceus, Eucommia folium, and Codonopsis pilosula) on intestinal antioxidant capacity and colonic microbiota in weaned pigs. A total of 18 piglets [Duroc × (Landrace × Yorkshire)] with the initial body weight of 5.99 ± 0.13 kg (weaned at 21 days) were randomly divided into two groups (n = 9): the control group (CON, basal diet) and the HEM treatment group (HEM, 1,000 mg/kg HEM + basal diet). The experiment period lasted for 14 days. Our results showed that dietary supplementation with HEM modulated the antioxidant capacity through decreasing the activity of superoxide dismutase (SOD) in the ileum and glutathione peroxidase (GSH-PX) in the serum, and decreasing the mRNA expression of Kelch like-ECH-associated protein 1 (Keap1) in the jejunum and the protein level of Keap1 in the ileum. Moreover, the HEM group modified the composition of colonic microbiota with affecting relative abundances of the Firmicutes and Bacteroidetes at the phylum level. Taken together, supplementation of HEM can regulate the antioxidant capacity and modify the composition of colonic bacteria in weaning piglets. This study provides new insights into the combination effects of herbal extracts on weaning piglets.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Herbal Extract Mixture Modulates Intestinal Antioxidative Capacity and Microbiota in Weaning Piglets

et al. 2021

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“…The dietary grape seed and grape marc extract improved the gain:feed ratio and decreased inflammation in weaning pigs without effects on the antioxidant system and vitamin E status [6,13]. An optimized polyphenol mixture extracted from apples, grape seeds, green tea, and olive leaves improved antioxidant status, including the plasma antioxidant activity of post-weaning piglets, and counteracted some of the negative effects that occur when piglets were challenged with Escherichia coli [14,15].…”

Section: Introductionmentioning

confidence: 99%

Red Grape Pomace Rich in Polyphenols Diet Increases the Antioxidant Status in Key Organs—Kidneys, Liver, and Spleen of Piglets

Chedea

Palade

Pelmuş

et al. 2019

Animals

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The aim of this work was to evaluate the influence of a diet containing 5% dried GP on the antioxidant status (total antioxidant status (TAS), antioxidant enzyme activity (catalase-CAT, superoxide dismutase-SOD, and gluthatione peroxidase-GPx), and lipid peroxidation) on the key organs of the liver, kidneys, and spleen in relation to health status as indicated by blood biochemical parameters and total polyphenol content in the blood, organs (liver, spleen, kidney, mesenteric lymph nodes, heart, and brain) and Longissimus dorsi muscle in piglets. The GP diet results in a significant increase of TAS in the liver, spleen, and kidneys, with increased CAT activity in the spleen and kidneys, increased SOD activity in the liver, kidneys, and spleen, and increased GPx activity in the kidneys, as well as a decrease in lipid peroxidation in the liver and kidneys. The GP included in the piglets’ feed contained polyphenols that showed antioxidant activity and were absorbed in the plasma, contributing to maintaining the good health of the animals. The inclusion of 5% GP inclusion in the diets of piglets is beneficial for overall normal blood constituent metabolism and helps to maintain piglet health by increasing the polyphenol content in blood plasma and antioxidant activity in the liver, spleen, and kidneys.

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“…Newborn infants and young animals generally have not established an appropriate balance in the gastrointestinal tract and therefore often suffer from oxidative stress (Khaled, ). Oxidative stress has been implicated as a causative agent in the induction and progression of weaning diarrhoea (Jiang et al., ). The accumulation of oxidative radicals such as reactive oxygen species (ROS) and tissue reactive nitrogen species (RNS) causes DNA damage and also destroys lipids and other essential cellular macromolecules (Langie et al., ), which could then induce cell apoptosis leading the death of intestinal epithelial cells, and eventually leads to increased intestinal permeability and diarrhoea.…”

Section: Introductionmentioning

confidence: 99%

Supplemental lipoic acid relieves post‐weaning diarrhoea by decreasing intestinal permeability in rats

Fan

Tan

Jin

et al. 2015

Animal Physiology Nutrition

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Lipoic acid (LA) is a naturally existing substance which widely distributed in the cellular membranes and cytosol of animal cells. Its intracellular functions include quenching of free radicals and repairing oxidized proteins. The purpose of this study was to evaluate the effects of LA on post-weaning diarrhoea using a rat model. Sixty weaned rats were fed either a basal diet or a LA-supplemented diet, or a zinc oxide (ZnO)-supplemented diet as a positive control. Rats in the LA and ZnO groups had better performance and reduced incidence of diarrhoea (p < 0.05). Both LA and ZnO treatments enhanced intestinal homeostatic and architecture, significantly decreased urinary lactulose to mannitol ratios (p < 0.05) and increased the expression of the intestinal mucosal tight junction proteins occludin (OCLN) and zonula occludens protein-1 (ZO-1) (p < 0.05). LA significantly increased the activities of antioxidant enzymes, and reduced glutathione while decreasing the levels of oxidative glutathione and malondialdehyde in the intestinal mucosa (p < 0.05). Furthermore, an in vitro study indicated that supplementation with LA in IEC-6 intestinal epithelial cells significantly enhanced the expression of OCLN and ZO-1 under hydrogen peroxide-induced oxidative stress. Collectively, these results suggest that LA relieves post-weaning diarrhoea by reducing intestinal permeability and improving antioxidant indices.

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The effect of plant polyphenols on the antioxidant defence system of weaned piglets subjected to an <i>Escherichia coli</i> challenge

Cited by 14 publications

References 38 publications

Herbal Extract Mixture Modulates Intestinal Antioxidative Capacity and Microbiota in Weaning Piglets

Herbal Extract Mixture Modulates Intestinal Antioxidative Capacity and Microbiota in Weaning Piglets

Red Grape Pomace Rich in Polyphenols Diet Increases the Antioxidant Status in Key Organs—Kidneys, Liver, and Spleen of Piglets

Supplemental lipoic acid relieves post‐weaning diarrhoea by decreasing intestinal permeability in rats

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