2023
DOI: 10.1002/dad2.12463
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The effect of plasma cortisol on hippocampal atrophy and clinical progression in mild cognitive impairment

Abstract: IntroductionBoth elevated cortisol and hippocampal volume have been linked to an increased risk for the development of Alzheimer's disease (AD). This longitudinal study assessed the effects of plasma cortisol on hippocampal atrophy and clinical progression rates in patients with mild cognitive impairment (MCI).MethodsPatients with amnestic MCI (n = 304) were selected from the Alzheimer's Disease Neuroimaging Initiative (ADNI) based on availability of baseline plasma cortisol and hippocampal volume measures, as… Show more

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