The effect of platelet-rich plasma injection on lateral epicondylitis following failed conservative management

Brkljac, Milos; Kumar, Shyam; Kalloo, Dale; Hirehal, Kiran

doi:10.1016/j.jor.2015.10.018

Cited by 18 publications

(16 citation statements)

References 20 publications

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“…However, Brkljac et al . in their study concluded that an injection of PRP improves pain and function in patients suffering from LE where conservative management has failed 20. Similarly, Raeissadat et al .…”

Section: Discussionmentioning

confidence: 85%

A comparative study to evaluate the efficacy of platelet-rich plasma and triamcinolone to treat tennis elbow

Seetharamaiah

Gantaguru

Basavarajanna

2017

IJOO

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Background:Lateral elbow pain is common with a population prevalence of 1%–3%. The study was a comparative trial to validate the efficacy of single injection of platelet-rich plasma (PRP) for tennis elbow as compared with single injections of triamcinolone and placebo (normal saline) over a short term period.Materials and Methods:Comparative trial with 3- and 6-month followup evaluated with visual analog scale (VAS) and facial pain scale (FPS). Our study included a total of eighty patients with unilateral or bilateral tennis elbows. The study population included patients between 20 and 40 years age group belonging to either sex with seventy unilateral and ten bilateral affections for more than 3-month duration. Patients suffering from elbow pain due to other problems or those who have received any form of injection were excluded from the study. One milliliter of 2% Xylocaine injection was given before injecting the proposed formulation under trial. VAS and FPS were used for scoring pain. Kruskal–Wallis test and Mann–Whitney U-tests were used for statistical analyses at 12 and 24 weeks.Results:Overall, 49 females and 31 males were included with thirty elbows in each group. Both the PRP and triamcinolone groups had better pain relief at 3 and 6 months as compared to normal saline group (P < 0.05), but at 6 months followup, the PRP group had statistically significant better pain relief than triamcinolone group. In the triamcinolone group, 13 patients had injection site hypopigmentation and 3 patients had subdermal atrophy.Conclusion:Over a short term period, PRP gives better pain relief than triamcinolone or normal saline in tennis elbow which needs to be validated over long term period by further studies.

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Section: Discussionmentioning

confidence: 85%

A comparative study to evaluate the efficacy of platelet-rich plasma and triamcinolone to treat tennis elbow

Seetharamaiah

Gantaguru

Basavarajanna

2017

IJOO

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“…Thus, it remains an area of ongoing investigation in orthopaedics. 1,5,16 PRP has been used successfully to treat a number of tendinopathies, including lateral epicondylitis. Peerbooms et al 21 published a randomized controlled trial comparing PRP with corticosteroid injections for the treatment of lateral epicondylitis in 100 patients.…”

Section: Discussionmentioning

confidence: 99%

“…1,22 PRP injections have compared favorably with steroid injections for the short-term management of lateral epicondylitis and have been used successfully to treat cases that failed nonoperative management. 1,5 This retrospective case series aimed to compare the clinical outcomes of patients treated with PRP injections to those treated with open surgical debridement for recalcitrant type 1 ME.…”

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confidence: 99%

Platelet-Rich Plasma Is an Equal Alternative to Surgery in the Treatment of Type 1 Medial Epicondylitis

Bohlen

Schwartz

et al. 2020

Orthopaedic Journal of Sports Medicine

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Background: Medial epicondylitis (ME) is characterized as an overuse injury resulting in pathological alterations of the common flexor tendon at the elbow. Platelet-rich plasma (PRP) has recently become of interest in the treatment of musculoskeletal conditions as an alternative to operative management. Purpose: To compare the outcomes of recalcitrant type 1 ME after treatment with either PRP or surgery. Study Design: Cohort study; Level of evidence, 3. Methods: To compare the 2 methods of treatment, we performed a retrospective review of 33 patients diagnosed with type 1 ME from 2006 to 2016 with a minimum clinical follow-up of 1 year who had failed an initial nonoperative treatment program of injections, medication, topical creams, and/or physical therapy. Overall, 15 patients were treated with a series of 2 leukocyte-rich PRP injections, and 18 patients were treated with surgery. Outcome measures included time to pain-free status, time to full range of motion (ROM), the Mayo Elbow Performance Score (MEPS), and the Oxford Elbow Score (OES). Each patient had at least 1-year follow-up. They were then contacted by telephone to determine final scores at a minimum 2-year follow-up. Unsuccessful outcomes were determined by the Nirschl grading system and failure to reach pain-free status, achieve baseline ROM, or return to previous activity. Results: The mean final follow-up was 3.9 years. A statistically significant improvement was noted in both time to full ROM (42.3 days for PRP vs 96.1 days for surgery; P < .01) and time to pain-free status (56.2 days for PRP vs 108.0 days for surgery; P < .01). Successful outcomes were observed in 80% of patients treated with PRP and 94% of those treated operatively ( P = .37). No significant difference was found in return-to-activity rates, overall successful outcomes, MEPS scores, or OES scores. Conclusion: In this case series, the use of PRP showed clinically similar outcomes to those of surgery in recalcitrant type 1 ME. PRP can be considered as an alternative to surgery in the treatment of recurrent ME, with an earlier time to full ROM and time to pain-free status compared with surgery.

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“…Due to angiogenesis, increase growth factor expression and cell proliferation, platelet-rich plasma therapy is used to increase the reparative process and tensile strength in chronic tendinopathies. 20 Some studies showed that platelet-rich plasma therapy decreases pain and increases functional improvement 16,17 whereas other studies showed inconclusive results. 18,15,[21][22] Hence, this study was conducted to find out the efficacy of platelet-rich plasma in terms of pain relief and functional improvement.…”

Section: Require Further Investigation 19mentioning

confidence: 99%

Effects of intralesional platelet-rich plasma in the patients with lateral epicondylitis of elbow

Islam

Shakoor

Mahjabin

et al. 2019

Bangabandhu Sheikh Mujib Medical University Journal

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Lateral epicondylitis (tennis elbow) is a major cause of musculoskeletal pain involving common extensor origin of the forearm. This study was done to determine the effects of platelet-rich plasma on 15 patients with lateral epicondylitis. Selected patients were given intralesional platelet-rich plasma injection, activity of daily living instructions and paracetamol. Patients were assessed every 14 days interval by visual analogue scale, and the patient rated tennis elbow evaluation. Treatment response according to visual analogue scale and patient rated tennis elbow evaluation tool, the difference of improvement was found in respect to time, from pretreatment W1 (just before 1st Intervention) score to W11 score in every alternate week (p<0.005). This indicates that intralesional platelet-rich plasma is effective in the patients with lateral epicondylitis of elbow.

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The effect of platelet-rich plasma injection on lateral epicondylitis following failed conservative management

Cited by 18 publications

References 20 publications

A comparative study to evaluate the efficacy of platelet-rich plasma and triamcinolone to treat tennis elbow

A comparative study to evaluate the efficacy of platelet-rich plasma and triamcinolone to treat tennis elbow

Platelet-Rich Plasma Is an Equal Alternative to Surgery in the Treatment of Type 1 Medial Epicondylitis

Effects of intralesional platelet-rich plasma in the patients with lateral epicondylitis of elbow

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