The Effect of Platelet-Rich Plasma on Autologous Osteochondral Transplantation

Smyth, Niall A.; Haleem, Amgad M.; Murawski, Christopher D.; Hương, Trần Thu; Deland, Jonathan T.; Kennedy, John G.

doi:10.2106/jbjs.l.01497

Cited by 66 publications

(43 citation statements)

References 46 publications

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“…Therefore it is important of the interface integration for the cartilage repair. PRP may enhance cartilage repair at the graft interface through recruitment of mesenchymal stem cells49. The introduction of rBMSC in PRP scaffolds may thus facilitate the recruitment efficiency.…”

Section: Discussionmentioning

confidence: 99%

Comparative evaluation of leukocyte- and platelet-rich plasma and pure platelet-rich plasma for cartilage regeneration

Yin

Zhang

et al. 2017

Sci Rep

103

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Platelet-rich plasma (PRP) has gained growing popularity in the treatment of articular cartilage lesions in the last decade. However, the potential harmful effects of leukocytes in PRP on cartilage regeneration have seldom been studied in vitro, and not at all in vivo yet. The objective of the present study is to compare the effects of leukocyte- and platelet-rich plasma (L-PRP) and pure platelet-rich plasma (P-PRP) on cartilage repair and NF-κB pathway, in order to explore the mechanism underlying the function of leukocytes in PRP in cartilage regeneration. The constituent analysis showed that P-PRP had significantly lower concentrations of leukocytes and pro-inflammatory cytokines compared with L-PRP. In addition, cell proliferation and differentiation assays indicated P-PRP promoted growth and chondrogenesis of rabbit bone marrow mesenchymal stem cells (rBMSC) significantly compared with L-PRP. Despite similarity in macroscopic appearance, the implantation of P-PRP combining rBMSC in vivo yielded better cartilage repair results than the L-PRP group based on histological examination. Importantly, the therapeutic effects of PRP on cartilage regeneration could be enhanced by removing leukocytes to avoid the activation of the NF-κB pathway. Thus, PRP without concentrated leukocytes may be more suitable for the treatment of articular cartilage lesions.

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Section: Discussionmentioning

confidence: 99%

Comparative evaluation of leukocyte- and platelet-rich plasma and pure platelet-rich plasma for cartilage regeneration

Yin

Zhang

et al. 2017

Sci Rep

103

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“…Smyth et al[56] showed in a systematic review that 18 of 21 (85.7%) basic science papers reported positive effects of PRP on cartilage repair. Additionally, Smyth et al[57] found in a rabbit model, that application of PRP at time of AOT improved the integration of the osteochondral graft at the cartilage interface and decreased graft degeneration. In clinical studies, Guney et al[58] performed a randomized control trial in 19 OLT patients and reported that BMS with PRP had better functional outcomes when compared with BMS alone.…”

Section: Biologic Augumentation For Cartilage Repairmentioning

confidence: 99%

Current management of talar osteochondral lesions

Gianakos¹,

Yasui²,

Hannon³

et al. 2017

WJO

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Osteochondral lesions of the talus (OLT) occur in up to 70% of acute ankle sprains and fractures. OLT have become increasingly recognized with the advancements in cartilage-sensitive diagnostic imaging modalities. Although OLT may be treated nonoperatively, a number of surgical techniques have been described for patients whom surgery is indicated. Traditionally, treatment of symptomatic OLT have included either reparative procedures, such as bone marrow stimulation (BMS), or replacement procedures, such as autologous osteochondral transplantation (AOT). Reparative procedures are generally indicated for OLT < 150 mm2 in area. Replacement strategies are used for large lesions or after failed primary repair procedures. Although short- and medium-term results have been reported, long-term studies on OLT treatment strategies are lacking. Biological augmentation including platelet-rich plasma and concentrated bone marrow aspirate is becoming increasingly popular for the treatment of OLT to enhance the biological environment during healing. In this review, we describe the most up-to-date clinical evidence of surgical outcomes, as well as both the mechanical and biological concerns associated with BMS and AOT. In addition, we will review the recent evidence for biological adjunct therapies that aim to improve outcomes and longevity of both BMS and AOT procedures.

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“…However, the lack of proper controls necessitates further investigations regarding the clinical use of PRP for OA. In an acute femoral defect model, the treatment of osteochondral grafts with PRP prior to implantation actually led to the improvement of graft-host integration when compared to grafts treated with saline solution [162], further indicating that PRP can decrease cartilage degeneration via the inhibition of inflammatory signals and the induction of neo-cartilage integration. Given the multifarious properties of PRP, future combinatory strategies can aim to leverage specific PRP effects through the co-delivery of synergistic or inhibitory factors.…”

Section: Strategies For Controlling Delivery Of Biologicsmentioning

confidence: 99%

Strategies for controlled delivery of biologics for cartilage repair

Lam

Kasper

et al. 2015

Advanced Drug Delivery Reviews

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The delivery of biologics is an important component in the treatment of osteoarthritis and the functional restoration of articular cartilage. Numerous factors have been implicated in the cartilage repair process, but the uncontrolled delivery of these factors may not only reduce their full reparative potential and can also cause unwanted morphological effects. It is therefore imperative to consider the type of biologic to be delivered, the method of delivery, and the temporal as well as spatial presentation of the biologic to achieve the desired effect in cartilage repair. Additionally, the delivery of a single factor may not be sufficient in guiding neo-tissue formation, motivating recent research towards the delivery of multiple factors. This review will discuss the roles of various biologics involved in cartilage repair and the different methods of delivery for appropriate healing responses. A number of spatiotemporal strategies will then be emphasized for the controlled delivery of single and multiple bioactive factors in both in vitro and in vivo cartilage tissue engineering applications.

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The Effect of Platelet-Rich Plasma on Autologous Osteochondral Transplantation

Abstract: The use of PRP as a biological adjunct to autologous osteochondral transplantation has the clinical potential to enhance graft integration, decrease cartilage degeneration, and improve clinical outcomes of autologous osteochondral transplantation.

Cited by 66 publications

References 46 publications

Comparative evaluation of leukocyte- and platelet-rich plasma and pure platelet-rich plasma for cartilage regeneration

Comparative evaluation of leukocyte- and platelet-rich plasma and pure platelet-rich plasma for cartilage regeneration

Current management of talar osteochondral lesions

Strategies for controlled delivery of biologics for cartilage repair

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