The effect of plateletpheresis on the fenwal CS‐3000 on donor platelet counts

Kalish, Robert I.; Chambers, Linda A.; Linden, Jeanne V.

doi:10.1002/jca.2920030408

Cited by 24 publications

(20 citation statements)

References 10 publications

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“…Compared to results reported in the literature, our COM.TEC CE results (57 ± 15%) were similar to those reported: 52-55% [13,17,18]. However, our Amicus results (55 ± 15%) were lower than the reported averages of 66-73% [8][9][10][11][19][20][21][22]. On the other hand, when comparing the instruments with regard to PLT yield/blood volume processed, the Amicus showed a significantly higher ratio compared to the COM.TEC (0.42 vs. 0.33; p < 0.001).…”

Section: Discussioncontrasting

confidence: 54%

Comparison of Plateletpheresis on the Fenwal Amicus and Fresenius Com.Tec Cell Separators

Altuntaş

Sarı²,

Koçyiğit³

et al. 2008

Transfus Med Hemother

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Background: A variety of apheresis devices are now available on the market for plateletapheresis. We compared two apheresis instruments (Fenwal Amicus and Fresenius COM.TEC) with regard to processing time, platelet (PLT) yield and efficiency, and white blood cell (WBC) content. Material and Methods: Donors undergoing plateletpheresis were randomly separated into two groups (either the Amicus or the COM.TEC cell separator). Results: In the pre-apheresis setting, 32 plateletpheresis procedures performed with each instrument revealed no significant differences in donors’ sex, age, weight, height and total blood volume between the two groups. However, the preapheresis PLT count was higher with the COM.TEC than with the Amicus (198 ×10³/µl vs. 223 ×10³/µl; p = 0.035). The blood volume processed to reach a target PLT yield of ≧3.3 ×10¹¹ was higher in the COM.TEC compared to the Amicus (3,481 vs. 2,850 ml; p < 0.001). The median separation time was also significantly longer in the COM.TEC than in the Amicus (61 vs. 44 min; p < 0.001). 91 and 88% of the PLT products collected with the Amicus and the COM.TEC, respectively, had a PLT count of ≧3.3 ×10¹¹ (p = 0.325). All products obtained with both instruments had WBC counts lower than 5 ↔10⁶, as required. There was no statistical difference with regard to collection efficiency between the devices (55 ± 15 vs. 57 ± 15%; p = 0.477). However, the collection rate was significantly higher with the Amicus compared to the COM.TEC instrument (0.077 ± 0.012 ×10¹¹ vs. 0.057 ± 0.008 ×10¹¹ PLT/min; p < 0.001). Conclusion: Both instruments collected platelets efficiently. Additionally, consistent leukoreduction was obtained with both instruments; however, compared with the COM.TEC instrument, the Amicus reached the PLT target yield more quickly.

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Section: Discussioncontrasting

confidence: 54%

Comparison of Plateletpheresis on the Fenwal Amicus and Fresenius Com.Tec Cell Separators

Altuntaş

Sarı²,

Koçyiğit³

et al. 2008

Transfus Med Hemother

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“…found a 29.4% decrease in PLT count after donation, which was not clinically significant. [7] In the present study, five out of 237 donors (N = 5, Amicus) showed a post donation PLT ct of <100×10 9 /L (Range 80-100). All five donors had a pre donation PLT ct between 150-200×10 9 /L.…”

Section: Discussionsupporting

confidence: 46%

Comparison of plateletpheresis on three continuous flow cell separators

Tendulkar

Rajadhyaksha

2009

Asian J Transfus Sci

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Introduction:Platelet concentrate (PC) remains one of the most important support measures in thrombocytopenic patients. An efficient cell separator is a prerequisite for an optimally functioning apheresis setup. Donor blood count may undergo a temporary reduction after the procedure.Aim:The aim was to find the extent of reduction in donor blood count (hemoglobin, hematocrit, white blood cell, and platelet) after plateletpheresis and to evaluate the cell separator for collection efficiency, processing time, and leukoreduction.Study Design and Methods:Two hundred and thirty seven procedures performed on the Amicus (N = 121), Fenwal CS-3000 Plus (N = 50) and Cobe spectra (N = 66) in a one year period were evaluated. The procedures performed on the continuous flow centrifugation (CFC) cell separators and donor blood counts (pre and post donation) done were included in the study.Results:The percent reduction in hemoglobin (HB), hematocrit (HCT), white blood cell (WBC) and platelet count ((PLT ct) was 2.9, 3.1, 9, 30.7 (Mean, N = 237) respectively after the procedure. The post donation PLT ct reduced to < 100×109/L (range 80-100) in five donors (N = 5/237, Amicus). The pre donation PLT ct in them was 150-200×109/L. Collection efficiency (percent) of Amicus (79.3) was better as compared to the other two machines (CS: 62.5, Cobe: 57.5). PC collected on Cobe spectra had <1×106 WBC. The donor pre donation PLT levels had a positive correlation to the product PLT yield (r = 0.30, P = 0.000).Conclusion:Monitoring donor blood counts helps to avoid pheresis induced adverse events. A cautious approach is necessary in donors whose pre donation PLT ct is 150-200×109/L. The main variable in PLT yield is donor PLT ct (pre donation). High collection efficiency is a direct measure of an optimally functioning cell separator.

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“…In 12% of the procedures, the mean yield was < 3 x 10 11 /unit when the pre-donation platelet count was < 200 x 10 3 /µl 4 . Many other studies have also demonstrated significant positive correlation between the donor platelet count and the yield of the product [10][11][12] .…”

Section: Discussionmentioning

confidence: 83%

“…Figure 1 shows a direct correlation between predonation platelet count and the platelet yield (r = 0.446, p < 0.001). The platelet count was > 3x 10 11 in 83% of procedures. Platelet yield was negatively correlated with MPV (r = -0.447) and PDW (r = -0.396) and was not found to be statistically significant as shown in Figure 2 and Figure 3 respectively.…”

Section: Resultsmentioning

confidence: 92%