The Effect of Polyethylene Glycol on Mammalian Nerve Impulses

A systematic review and meta‐analysis of perineural dexamethasone for peripheral nerve blocks

“…During in-vitro studies, Ma et al demonstrated a potential protective effect of dexamethasone against local anaesthetic-induced cell injury [58] and a series of 2000 intrathecal injections of 8 mg dexamethasone for the treatment of post-traumatic visual disturbance in 200 patients failed to demonstrate any neurological sequelae [59]. Nevertheless, clinicians must be aware that perineural dexamethasone represents off-label use and solutions free of neurotoxic preservatives should be used [60,61]. Finally, although the safety profile of perineural dexamethasone is promising, it should be noted that intravenous dexamethasone at a dose of 0.1-0.2 mg.kg À1 could have a comparable analgesic effect [16,20,62] and could obviate the need for perineural injection.…”

Alzheimer’s Disease Pathogenesis: The Denied Access Model

“…They found 40% PEG abolished the compound action potential within an hour due to increased osmotic pressures creating a hypertonic environment and shrinkage of the axon. These structural changes may lead to reduced ion permeability, neuronal stress, and eventually neuronal death [117]. These results suggest the frog sciatic nerve may be an ideal tissue for neurophysiology experiments to test the effect of viscosity on neuronal function.…”

“…Furthermore, they found that acrylamide may be associated with an increase in lipid peroxidation and reduction of the anti-oxidative capacity. Another experiment examined the direct effects of polyethylene glycol (PEG) on isolated rabbit sciatic nerves [117]. They found 40% PEG abolished the compound action potential within an hour due to increased osmotic pressures creating a hypertonic environment and shrinkage of the axon.…”

Protein Gelation around Axons Inhibits Action Potential Propagation in Nerve Fibers

“…With the NA-100 Neuroamp Extracellular Amplifier (iWorx), the nerve was stimulated at 0.25 V and the CAP was monitored. Once the CAP was stable [17], testing solutions were applied to the capsule and CAP was recorded every 30 s for 15 min. The sciatic nerve was moisturized by applying Ringer's solution every 5 min, which enables the nerve remained functional for 2-4 h before CAP decline occurred.…”