The effect of polyethylene glycol on the stability of pores in polyvinyl alcohol hydrogels during annealing

Bodugoz-Senturk, Hatice; Choi, Jeeyoung; Oral, Ebru; Kung, Jean H.; Macias, Celia E.; Braithwaite, Gavin; Muratoglu, Orhun K.

doi:10.1016/j.biomaterials.2007.09.015

Cited by 80 publications

(68 citation statements)

References 24 publications

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“…Thermal annealing has been employed as a processing strategy to alter the microstructure of polymeric materials, most often to increase the crystallinity or to modulate microphase separation in order to improve material or application dependent properties, including strength or stiffness [23–25], hardness [23], viscoelastic properties [26, 27], water absorptive properties [26, 28], or photoluminescence [28]. In particular, thermal annealing for one hour at 160°C of polyvinyl alcohol (PVA) hydrogels resulted in increased creep resistance and decreased water content which was attributed to a thermally induced change in microstructure initiating a collapse in hydrogel pore structure [26, 29, 30].…”

Section: Resultsmentioning

confidence: 99%

“…In particular, thermal annealing for one hour at 160°C of polyvinyl alcohol (PVA) hydrogels resulted in increased creep resistance and decreased water content which was attributed to a thermally induced change in microstructure initiating a collapse in hydrogel pore structure [26, 29, 30]. Additionally, thermal annealing of poly (L-lactic acid) (PLLA) electrospun nanofibers in the dry state at 75°C for 24 hours resulted in a decrease in fiber diameter accompanied by enhanced stiffness, strength, creep resistance and decreased in water content.…”

Section: Resultsmentioning

confidence: 99%

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A Permanent Change in Protein Mechanical Responses Can be Produced by Thermally-Induced Microdomain Mixing

Sallach

Leisen

Caves

et al. 2009

Journal of Biomaterials Science, Polymer Edition

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Electrospinning was employed to fabricate three dimensional fiber networks from a recombinant amphiphilic elastin-mimetic triblock protein polymer and the effects of moderate thermal conditioning (60°C, 4h) on network mechanical responses investigated. Significantly, while cryo-high resolution scanning electron microscopy (cryo-HRSEM) revealed that macroscopic and microscopic morphology of the network structure was unchanged, solid-state 1H NMR spectroscopy demonstrated enhanced interphase mixing of hydrophobic and hydrophilic blocks. Significantly, thermal annealing triggered permanent changes in network swelling behavior (28.75 ± 2.80 non-annealed vs. 13.55 ± 1.39 annealed; p < 0.05) and uniaxial mechanical responses, including Young’s modulus (0.170 ± 0.010 MPa non-annealed vs. 0.366 ± 0.05 MPa annealed; p < 0.05) and ultimate tensile strength (0.079 ± 0.008 MPa vs 0.119 ± 0.015 MPa; p < 0.05). To our knowledge, these investigations are the first to note that mechanical responses of protein polymers can be permanently altered through a temperature-induced change in microphase mixing.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

A Permanent Change in Protein Mechanical Responses Can be Produced by Thermally-Induced Microdomain Mixing

Sallach

Leisen

Caves

et al. 2009

Journal of Biomaterials Science, Polymer Edition

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“…Our group has developed flexible PVA hydrogels formulations with the potential for replacing defective cartilage with a synthetic cartilage-like material [7,13]. However, the subcutaneous use of these inert acellular gels could pose similar complications experienced with HDPPE, including extrusion if placed under a poorly vascularized environment, and the limited capacity of tissues to heal over the implant after direct trauma.…”

Section: Discussionmentioning

confidence: 96%

Porous Poly(vinyl alcohol)-Alginate Gel Hybrid Construct for Neocartilage Formation Using Human Nasoseptal Cells

Bichara

Zhao

Hwang

et al. 2010

Journal of Surgical Research

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“…Unlike the gel synthesized by Muratoglu et al, the PAAm chains are covalently cross-linked to increase the retraction force of the network and to prevent leakage of the polymer chains. 24 Second, we dry and anneal the gel at elevated temperature. The drying process removes water and concentrates the PVA in the mixture.…”

Section: Resultsmentioning

confidence: 99%

Stiff, strong, and tough hydrogels with good chemical stability

2014

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Most hydrogels have poor mechanical properties, severely limiting their scope of applications.Here we report on a hybrid hydrogel that combines extremely high stiffness, strength, and toughness, while maintaining physical integrity in electrolyte solutions. The hydrogel consists of a hydrophilic polymer network that is covalently cross-linked and a second polymer network that can crystallize. We show that the crystallites serve as physical cross-links for the second network.The crystallites contribute to the high stiffness and strength of the hydrogel; they unzip and dissipate energy under deformation, and reform due to the incompatibility of the two polymers in the hydrogel. The crystallite-toughened hydrogel can achieve an elastic modulus of 5 MPa, a strength of 2.5 MPa, and a fracture energy of 14,000 Jm -2 . Unlike alginate-based hybrid hydrogels, this hydrogel preserves its mechanical properties in electrolyte solutions and could be considered for further development in a variety of engineering applications. 20 Unfortunately, hydrogels synthesized using this method are compliant and brittle. 22 It is possible to achieve higher stiffness and toughness using a dry-anneal method, but only at the expense of a much lower water content ( Supplementary Fig. S1). 23 Muratoglu and coworkers polymerized acrylamide monomers in the pores of a PVA hydrogel to form uncross-linked chains, and showed that the equilibrium water content of the resulting gels increased with acrylamide content, while the coefficient of friction, tear strength and creep resistance decreased. 21Here we propose that a hybrid network of a crystalline polymer and a covalently crosslinked hydrophilic polymer may form a hydrogel with robust mechanical properties and good chemical stability: the crystalline polymer can generate a large number of crystallites to serve as physical cross-links that are both stable and reversible; the covalently cross-linked hydrophilic polymer maintain the elasticity of the network during deformation and controls the swelling of the hydrogel. We describe one such hybrid hydrogel that combines extremely high stiffness, strength, and toughness. The hydrogel consists of a hydrophilic polyacrylamide (PAAm) polymer network that is covalently cross-linked and a PVA network that forms crystallites. We show that the PVA crystallites result in a high cross-link density, thus producing a gel of remarkable stiffness and strength. The crystallites unzip under deformation, dissipating energy in the process and yielding a hydrogel with exceptional toughness. After deformation, unzipped crystallites recover at room temperature due to the incompatibility of the two polymers in the gel. The 4 crystallite-toughened hydrogel can achieve an elastic modulus of 5 MPa, a strength of 2.5 MPa, and a fracture energy of 14,000 Jm -2 . Moreover, these properties are stable, even in concentrated electrolyte solutions. ResultsWe prepared the hybrid hydrogels in a simple three-step protocol. First, we form a cross- Supplementary Fig. S2); e...

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The effect of polyethylene glycol on the stability of pores in polyvinyl alcohol hydrogels during annealing

Cited by 80 publications

References 24 publications

A Permanent Change in Protein Mechanical Responses Can be Produced by Thermally-Induced Microdomain Mixing

A Permanent Change in Protein Mechanical Responses Can be Produced by Thermally-Induced Microdomain Mixing

Porous Poly(vinyl alcohol)-Alginate Gel Hybrid Construct for Neocartilage Formation Using Human Nasoseptal Cells

Stiff, strong, and tough hydrogels with good chemical stability

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