The effect of polymer and CaCl2 concentrations on the sulfasalazine release from alginate-N,O-carboxymethyl chitosan beads

Tavakol, Moslem; Vasheghani‐Farahani, Ebrahim; Hashemi‐Najafabadi, Sameereh

doi:10.1186/2194-0517-2-10

Cited by 28 publications

(19 citation statements)

References 31 publications

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“…PU–alginate polymeric beads were prepared by the crosslinking of alginate chains by calcium chloride by the addition of polymeric blends into the crosslinking solution of calcium chloride. Alginate was crosslinked immediately in a Ca 2+ solution, and thus, microencapsulated beads were formed . On the contrary, PU did not get crosslinked in the calcium chloride solution.…”

Section: Resultsmentioning

confidence: 99%

“…Accurately weighed amounts of beads were immersed in 10 mL of each media at 37 ±0.5°C for 6 h. The swollen beads were taken out of the medium and weighed immediately in a microbalance; this was followed by blotting with a paper towel to remove excess water on the surface at fixed time intervals. The degree of swelling was calculated with the following formula:

Swelling degree (%) = \frac{(W - W 0)}{W 0} \times 100 %

where W is the weight of the beads after swelling and W 0 is the initial weight of the beads.…”

Section: Methodsmentioning

confidence: 99%

“…Alginate was crosslinked immediately in a Ca 21 solution, and thus, microencapsulated beads were formed. 25 On the contrary, PU did not get crosslinked in the calcium chloride solution. PU-alginate blends were partially crosslinked because of the presence of SA, and semi-IPN beads were prepared.…”

Section: Biodegradation Study (Sem)mentioning

confidence: 99%

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Synthesis of a novel pH‐sensitive polyurethane–alginate blend with poly(ethylene terephthalate) waste for the oral delivery of protein

Bhattacharyya

Mukhopadhyay

Kundu

2014

J of Applied Polymer Sci

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With the aim of using poly(ethylene terephthalate) (PET) waste for the synthesis of a value added product, we prepared polyurethane (PU) from bishydrohxyethylene terephthalate (BHET), a byproduct obtained from the glycolysis of PET. Biodegradable, waterswelling PU was synthesized by the reaction of BHET, hexamethylene diisocyanate, and poly(ethylene glycol) (PEG). Both BHET and PU were characterized by Fourier transform infrared spectroscopy, and the formation of PU was further confirmed by NMR analysis. The swelling behavior of PU in water was examined in terms of the various molecular weights of PEG. Semi-interpenetrating network beads of PU and sodium alginate were prepared with calcium chloride (CaCl 2 ) as a crosslinker to attain a pH sensitivity for successful oral protein/drug delivery. Bovine serum albumin (BSA) was used as a model protein. The pH-responsive swelling behavior and protein (BSA) release kinetics in different pH media corresponding to the gastrointestinal tract (pH 1.2 and 7.4) were investigated. The degree of swelling in the case of the PU-alginate beads at pH 1.2 was found to be at a minimum, whereas the degree of swelling was significantly elevated (1080%) at pH 7.4. This substantiated the pH sensitivity of the polymeric beads with a minimum loss of encapsulated protein in the stomach and the almost complete release of encapsulated protein in the intestine. This revealed good opportunities for oral protein/ drug delivery with a polymer derived from waste PET. Moreover, the fungal biodegradation study confirmed its compatibility with the ecological system.

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Section: Resultsmentioning

confidence: 99%

Swelling degree (%) = \frac{(W - W 0)}{W 0} \times 100 %

where W is the weight of the beads after swelling and W 0 is the initial weight of the beads.…”

Section: Methodsmentioning

confidence: 99%

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Synthesis of a novel pH‐sensitive polyurethane–alginate blend with poly(ethylene terephthalate) waste for the oral delivery of protein

Bhattacharyya

Mukhopadhyay

Kundu

2014

J of Applied Polymer Sci

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“…Carboxymethyl chitosan nanoparticles are prepared chiefly by ionic gelation process. Extensive research has been carried out to synthesize carboxymethyl chitosan nanoparticles loaded with drug by ionic gelation process . This can either be chemically crosslinked with glutaraldehyde (GA) and genipin or physically crosslinked with sodium tripolyphosphate, calcium chloride, and so on.…”

Section: Introductionmentioning

confidence: 99%

Carboxymethyl chitosan-montmorillonite nanoparticles for controlled delivery of isoniazid: evaluation of the effect of the glutaraldehyde and montmorillonite

Banik

Ramteke

Maji

2014

Polym. Adv. Technol.

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Chitosan, a natural biopolymer, is used for drug delivery application. But its potential application is limited by its low solubility in aqueous media. The present study was designed to prepare carboxymethyl chitosan (CMC), a water soluble derivative of chitosan, and evaluate the prospective of crosslinked CMC-Montmorillonite (MMT) nanoparticles for controlled delivery of isoniazid. The nanoparticles were characterized by Fourier Transmission Infrared Spectroscopy (FTIR), Nuclear Magnetic Resonance (NMR), X-ray diffraction (XRD), scanning electron microscopy (SEM), and Transmission emission microscopy (TEM). The effects of MMT and glutaraldehyde on nanoparticles were assessed with regard to encapsulation efficiency, percentage swelling degree, and cumulative release. Percentage swelling degree and cumulative release were studied in pH medium 1.2 and 7.4 for 6 h. The cumulative release was studied by UV-visible spectrophotometer. Cell viability study was performed by MTT assay analysis. FTIR and NMR study indicated the successful preparation of CMC. FTIR study confirmed the interaction of MMT with CMC. The exfoliation of MMT layers and molecular level dispersion of isoniazid in CMC was examined by XRD and TEM. SEM study showed that the surface of the CMC-MMT nanoparticles was smooth compared with those of CMC nanoparticles. Swelling and release of isoniazid from the nanoparticles increased with the decrease in the MMT and glutaraldehyde content. The percentage swelling degree and cumulative release was more in pH 1.2. Cell viability study revealed that CMC was not cytotoxic, and the nanoparticles containing MMT was less cytotoxic than those of MMT free nanoparticles. CMC-MMT nanoparticles can be exploited as potential drug carrier for controlled release applications.

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“…Also, the same anionic polymers have been used with CaCl 2 (ionotropic gelation) [11,12] or a mix of polymers with the salt [13,14].…”

Section: Introductionmentioning

confidence: 99%

Polyelectrolyte Complexation versus Ionotropic Gelation for Chitosan-Based Hydrogels with Carboxymethylcellulose, Carboxymethyl Starch, and Alginic Acid

Henao

Delgado

Contreras

et al. 2018

International Journal of Chemical Engineering

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e preparation of gels by charge interaction methods has been extensively studied, but it is not yet clear how these methods influence gel characteristics. e objective of this work was to study differences in morphology and surface charge of hydrogels prepared by ionotropic gelation, polyelectrolyte complexation, and a combination of both methods. us, the anionic charge was provided by carboxymethylcellulose (CMC), carboxymethylated starch (CMS), and alginic acid (AA); calcium chloride (CaCl 2 ) and chitosan (CS) were used for the ionotropic gelation and polyelectrolyte complexation, respectively. ose materials are commercially available, have low toxicity, and are widely used in the area. ese compounds interact through physical crosslinks, which are affected by physical changes of the medium. Our results showed that these two methods produced changes in the morphology of the hydrogels. CMC gels exhibited larger pores in the presence of CaCl 2 . In polyelectrolyte complexation, CMS produced an increased agglomeration of particles, while the addition of CaCl 2 to AA generated dispersed particles of size in the order of millimeters. Mixing both ionotropic gelation and polyelectrolyte complexation methods yielded gels of varied charge (568 mV for CMC, 502 mV for CMS, and 1713 mV for AA). FTIR spectra of the hydrogels showed interactions between the different polymeric compounds, being the greatest changes between 1250 and 1600 cm −1 , due possibly to the replacement of Na by Ca at crosslinking points. erefore, the method of gel preparation employed had a major influence on the size and pore distribution, parameters which in turn influence encapsulation and drug delivery in these systems.

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The effect of polymer and CaCl2 concentrations on the sulfasalazine release from alginate-N,O-carboxymethyl chitosan beads

Cited by 28 publications

References 31 publications

Synthesis of a novel pH‐sensitive polyurethane–alginate blend with poly(ethylene terephthalate) waste for the oral delivery of protein

Synthesis of a novel pH‐sensitive polyurethane–alginate blend with poly(ethylene terephthalate) waste for the oral delivery of protein

Carboxymethyl chitosan-montmorillonite nanoparticles for controlled delivery of isoniazid: evaluation of the effect of the glutaraldehyde and montmorillonite

Polyelectrolyte Complexation versus Ionotropic Gelation for Chitosan-Based Hydrogels with Carboxymethylcellulose, Carboxymethyl Starch, and Alginic Acid

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