The effect of polyphenol-rich chardonnay seed supplements on peripheral endothelial function

Corban, Michel; Widmer, R. Jay; Cilluffo, Rebecca; Kazeck, Makinzee; Lennon, Ryan J.; Lerman, Lilach O.; Lerman, Amir

doi:10.1007/s00394-020-02203-6

Cited by 9 publications

(9 citation statements)

References 34 publications

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“…The study participants were recruited from a cardiovascular outpatient population and clinic employees and were relatively young (mean age about 38 years) and predominately female, with cardiovascular risk factors controlled with medication and having "endothelial dysfunction" or a low baseline RHI (<2.0) at study entry. 112 In this population, systolic blood pressure was reduced 3 mmHg from baseline in both groups. Blood cholesterol levels did not significantly change over time, except for an 8% increase and an 11% decrease in triglycerides in Chardonnay grape seed flour versus comparator, respectively.…”

Section: Grape Berries Juice Powders or Marcmentioning

confidence: 75%

“…Specific to Chardonnay, Corban et al recently reported improvements in the reactive hyperemia index (RHI; EndoPAT2000), a measure of digital microvascular function, with 4 months of daily intake of either a defatted and milled Chardonnay grape seed flour or a comparative capsule with matched macronutrients, where the fat was matched with organic grape seed oil. The study participants were recruited from a cardiovascular outpatient population and clinic employees and were relatively young (mean age about 38 years) and predominately female, with cardiovascular risk factors controlled with medication and having “endothelial dysfunction” or a low baseline RHI (<2.0) at study entry . In this population, systolic blood pressure was reduced 3 mmHg from baseline in both groups.…”

Section: Data From Dietary Intervention Trials Of Grape Berries Juice...mentioning

confidence: 99%

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Chardonnay Marc as a New Model for Upcycled Co-products in the Food Industry: Concentration of Diverse Natural Products Chemistry for Consumer Health and Sensory Benefits

Holt

Barile

Wang

et al. 2022

J. Agric. Food Chem.

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Research continues to provide compelling insights into potential health benefits associated with diets rich in plant-based natural products (PBNPs). Coupled with evidence from dietary intervention trials, dietary recommendations increasingly include higher intakes of PBNPs. In addition to health benefits, PBNPs can drive flavor and sensory perceptions in foods and beverages. Chardonnay marc (pomace) is a byproduct of winemaking obtained after fruit pressing that has not undergone fermentation. Recent research has revealed that PBNP diversity within Chardonnay marc has potential relevance to human health and desirable sensory attributes in food and beverage products. This review explores the potential of Chardonnay marc as a valuable new PBNP ingredient in the food system by combining health, sensory, and environmental sustainability benefits that serves as a model for development of future ingredients within a sustainable circular bioeconomy. This includes a discussion on the potential role of computational methods, including artificial intelligence (AI), in accelerating research and development required to discover and commercialize this new source of PBNPs.

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Section: Grape Berries Juice Powders or Marcmentioning

confidence: 75%

Section: Data From Dietary Intervention Trials Of Grape Berries Juice...mentioning

confidence: 99%

Chardonnay Marc as a New Model for Upcycled Co-products in the Food Industry: Concentration of Diverse Natural Products Chemistry for Consumer Health and Sensory Benefits

Holt

Barile

Wang

et al. 2022

J. Agric. Food Chem.

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“…Endothelial dysfunction is a condition that precedes the development of atherosclerosis and CVD [ 38 ]. Endothelial dysfunction is characterized by reduced bioavailability of NO, an important vasodilator molecule produced by endothelial cells [ 35 ].…”

Section: Vascular Effectmentioning

confidence: 99%

“…In addition to these by-product sources, chardonnay seed (rich in polyphenols, fibers, and grape seed oil) supplementation has also been investigated on human endothelial function. Corban et al [ 38 ] evaluated endothelial function in hospitalized adults and elderly individuals with endothelial dysfunction using the reactive hyperemia-peripheral arterial tonometry (RH-PAT) technique. These individuals consumed the chardonnay seed supplement rich in polyphenols or without polyphenols.…”

Section: Vascular Effectmentioning

confidence: 99%

The Role of By-Products of Fruit and Vegetable Processing for the Dietary Treatment of Cardiovascular Risk Factors: A Narrative Review

et al. 2022

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Polyphenols-rich food has been utilized to induce a positive effect on human health. Considering that fruit and vegetable by-products (seeds, pomace, and peels) are sources of polyphenols, previous studies have investigated the effect of dietary supplementation with food by-products on cardiometabolic disorders, such as high fasting blood glucose, dyslipidemia, and obesity. Endothelial dysfunction has also been considered a cardiometabolic parameter, given that it precedes cardiovascular disease. However, there is a scarcity of narrative reviews reporting the effect of food by-product supplementation on cardiometabolic disorders in animal and human clinical trials. In this sense, the present narrative review aims to investigate the impact of fruit and vegetable by-product supplementation on cardiometabolic disorders in humans and animals, exploring the possible mechanisms whenever possible. Research articles were retrieved based on a search of the following databases: PubMed, ScienceDirect, and Google Scholar using the following keywords and synonyms combined: (“fruit by-products” or “food waste” or “pomace” or “bagasse” or “seeds” or “waste products”) AND (“heart disease risk factors” or “endothelial dysfunction” or “atherosclerosis”). It was shown that fruit and vegetable by-products could efficiently improve cardiometabolic disorders in patients with chronic diseases, including hypertension, type II diabetes mellitus, and dyslipidemia. Such effects can be induced by the polyphenols present in food by-products. In conclusion, food by-product supplementation has a positive effect on cardiometabolic disorders. However, further studies investigating the effect of food by-products on cardiometabolic disorders in humans are still necessary so that solid conclusions can be drawn.

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“…Initiatives to eliminate wasteful practices and, instead, utilize the whole plant have led to the discovery that marc contains a rich source of health-promoting molecules . Previous studies have shown that Chardonnay and other grape seed flours improve cardiovascular health, , gastrointestinal health via modulation of the microbiome, and modulation of inflammatory response, , suggesting that Chardonnay marc may also have the potential to benefit human well-being.…”

Section: Introductionmentioning

confidence: 99%

Characterization of Odorants in Chardonnay Marc Skins

Dein

Moore

Ricketts

et al. 2021

J. Agric. Food Chem.

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Chardonnay marc, consisting of grape skins, seeds, and stems, is a coproduct of grape juice production for Chardonnay wine making. The discovery that marc contains a rich source of health-promoting molecules has led to its growing popularity as a flavorful healthy food ingredient. However, the odorants responsible for its pleasant fruity aroma remain unknown. In this study, 35 odorants were identified in Chardonnay marc skins using solvent-assisted flavor evaporation (SAFE) and aroma extract dilution analysis (AEDA). Thirteen odorants were quantitated employing stable isotope dilution assays (SIDAs), and odor activity values (OAVs) were calculated. Odorants with OAVs >1 included 3-methylnonane-2,4-dione (hay, OAV 5800), β-ionone (floral, violets, OAV 2900), (2E,4E)-nona-2,4-dienal (fatty, OAV 1200), β-damascenone (cooked apple, OAV 370), hexanal (green, OAV 260), oct-1-en-3-one (mushroom, OAV 200), linalool (floral, citrus, OAV 61), (2E,4E)-deca-2,4-dienal (fatty, OAV 60), 2phenylethanol (floral, rose, OAV 16), 3-(methylsulfanyl)propanal (potato, OAV 3.7), HDMF (caramel, OAV 2.0), and ethyl octanoate (fruity, OAV 1.1). An odor simulation model prepared using odorants with OAVs >1 sensorially matched the aroma of the Chardonnay marc skins. This investigation establishes a foundation for future studies aimed at determining the contribution of individual Chardonnay marc components (skins, seeds, and stems) to the aroma profile of Chardonnay marc powder and aiding producers in delivering optimal and consistent aroma profiles by region.

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The effect of polyphenol-rich chardonnay seed supplements on peripheral endothelial function

Cited by 9 publications

References 34 publications

Chardonnay Marc as a New Model for Upcycled Co-products in the Food Industry: Concentration of Diverse Natural Products Chemistry for Consumer Health and Sensory Benefits

Chardonnay Marc as a New Model for Upcycled Co-products in the Food Industry: Concentration of Diverse Natural Products Chemistry for Consumer Health and Sensory Benefits

The Role of By-Products of Fruit and Vegetable Processing for the Dietary Treatment of Cardiovascular Risk Factors: A Narrative Review

Characterization of Odorants in Chardonnay Marc Skins

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