The Effect of Polysaccharides Peptides Ganoderma Lucidum to Aortic Foam Cell Count and Lipid Profile in Type 2 Diabetic Model Rattus Norvegicus Strain Wistar

Sargowo, Djanggan; Wihastuti, Titin Andri; Sukotjo, Cathrine Theodora; Anjani, Prasanti Mahesa; Handayani, Olivia; Adrian, Liemena Harold

doi:10.18585/inabj.v9i3.298

Cited by 3 publications

(3 citation statements)

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“…( 25) A previous study demonstrated that β-1,3/1,6-Dglucan from mycelia extract acts as an immunomodulator and reduces the inflammatory response to obesity due to consumption of a high-fat diet. (12,26) These findings provide potential treatment of obesity by using traditional medicine. In line with previous findings, the results of our study showed that b-1,3/1,6-D-glucan was able to counteract the negative effects of obesity and maintain normal kidney function.…”

Section: Discussionmentioning

confidence: 88%

β-1,3/1,6-D-glucan of Mycelia Extract Posses Renal Protection Potential and Reduces Nitric Oxide in Obese Subjects

et al. 2022

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BACKGROUND: Obesity has been widely reported to be associated with loss of kidney function. The efficacy of β-1,3/1,6-D-glucan as a traditional medicine for the improvement of inflammation and vascular status in obesity has known. However, there have been no further studies that prove the effect of β-1,3/1,6-D-glucan in inhibiting kidney injury as an impact of chronic inflammation exposure on obesity. This study aimed to investigate the impact of β-1,3/1,6-D-glucan from mycelia extract supplementation on renal function improvement based on serum nitric oxide (NO), ureum, and creatinine levels.METHODS: This was a randomized control trial study involving 69 obese subjects treated with or without β-1,3/1,6-D-glucan supplementation. The serum NO, ureum, and creatinine levels of the subjects were measured at baseline and post-treatment using enzyme-linked immunosorbent assay (ELISA) and then statistically analyzed with paired T-test.RESULTS: Although slightly decrease, no significant difference was found between the ureum and creatinine level at the baseline and and post-treatment (p=0.806, p=0.306, respectively) after β-1,3/1,6-D-glucan supplementation. Serum NO levels significantly decrease after treatment of β-1,3/1,6-D-glucan (p<0.001).CONCLUSION: Current study concludes that β-1,3/1,6-D-glucan from mycelia extract does not significantly lower urea and creatinine level, however, significantly able to reduce the serum NO concentration in obese subjects. Therefore, β-1,3/1,6-D-glucan from mycelia extract might have the renal protection potential in obesity.KEYWORDS: β-1,3/1,6-D-glucan, Ganoderma lucidum, renal function improvement, obesity

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Section: Discussionmentioning

confidence: 88%

β-1,3/1,6-D-glucan of Mycelia Extract Posses Renal Protection Potential and Reduces Nitric Oxide in Obese Subjects

et al. 2022

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“…Studies in GLPP has shown that treatment of GLPP decreased the levels of inflammatory cytokines in atherosclerotic mice model (23), atrial fibrillation (24), dyslipidemic and high risk coronary heart disease patients (25). Current results showed that hsCRP, and TNF-α were significantly decreased in both control and treatment groups.…”

Section: Discussionmentioning

confidence: 99%

Ganoderma lucidum Polysaccharide Peptide Reduces Oxidative Stress and Improves Renal Function in Patient with Cardiometabolic Syndrome

et al. 2023

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BACKGROUND: Cardiometabolic syndrome is a risk factor for the development of diseases related to cardiovascular disease and decreased renal function. Ganoderma lucidum polysaccharide peptide (GLPP) has been reported to have anti-inflammatory and antioxidant properties. The current study was conducted to investigate the role of GLPP in inflammatory, oxidative stress and renal function markers of cardiometabolic subjects.METHODS: A randomized double-blinded perspective control trial with pre-post design was conducted. Cardiometabolic syndrome subjects were treated with placebo or GLPP for 60 days. Blood serum was collected from each subject before the first capsule consumption and one day after the last capsule consumption. Serum tumor necrosis factor (TNF)-α, high-sensitivity-C-Reactive Protein (hs-CRP) and malondialdehyde (MDA) levels were measured using enzyme-linked immunosorbent assay, while superoxide dismutase (SOD) level was measured using colorimetric assay. Serum urea and creatinine levels were measured using a clinical analyzer. The Cockroft-Gault formula was used to calculate estimated glomerular filtration rate (eGFR).RESULTS: Compared with the control group, the MDA level was significantly reduced, while the SOD level was significantly increased in the GLPP treatment group. Furthermore, serum urea and creatinine were lowered, while eGFR was increased in the GLPP treatment group.CONCLUSION: Treatment of GLPP for 60 days could be beneficial for lowering oxidative stress and improving renal function of patients with cardiometabolic syndrome.KEYWORDS: Ganoderma lucidum, cardiometabolic syndrome, inflammation, oxidative stress, renal function

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“…As a traditional Chinese herbal medicine, G . lingzhi has many pharmaceutical effects, such as immunomodulatory activity [ 4 , 5 ], regulation of cardiovascular function [ 6 , 7 ], regulation of blood glucose [ 8 , 9 ], and a hepatoprotective effect [ 10 , 11 ]. Ganoderma are particularly recommended for their immune-supporting effects [ 2 ], and the medicinal evidence comes from both animal experiments [ 11 , 12 ] and clinical trials [ 13 , 14 ].…”

Section: Introductionmentioning

confidence: 99%

Improved production of polysaccharides in Ganoderma lingzhi mycelia by plasma mutagenesis and rapid screening of mutated strains through infrared spectroscopy

Zhang

et al. 2018

PLoS ONE

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As a traditional Chinese medicine, Ganoderma lingzhi has attracted increasing attention for both scientific research and medical application. In this work, in order to improve the production of polysaccharides from an original wide-type (WT) strain (named "RWY-0") of Ganoderma lingzhi, we applied atmospheric-pressure dielectric barrier discharge (DBD) nonthermal plasma to the protoplasts of RWY-0 for mutagenesis treatment. Through a randomly amplified polymorphic DNA (RAPD) assay, at least 10 mutagenic strains were confirmed. They also showed different mycelium characteristics in terms of shape, color, size and biomass in liquid fermentation. The mutant strains were examined by infrared spectroscopy, and based on the established near-infrared (NIR) quantification model, the polysaccharide contents in these mutants were quantitatively evaluated. As a result, we found that the Ganoderma polysaccharide contents in some of the mutant strains were significantly changed compared with that of the original WT strain. The polysaccharide content of RWY-1 G. lingzhi was considerably higher than that of the WT strain, with an increase of 25.6%. Thus, this preliminary work demonstrates the extension of the plasma mutagenesis application in acquiring polysaccharide-enhanced Ganoderma lingzhi mutants and shows the usefulness of NIR spectroscopy in the rapid screening of mutagenic strains for other important ingredients.

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The Effect of Polysaccharides Peptides Ganoderma Lucidum to Aortic Foam Cell Count and Lipid Profile in Type 2 Diabetic Model Rattus Norvegicus Strain Wistar

Cited by 3 publications

References 10 publications

β-1,3/1,6-D-glucan of Mycelia Extract Posses Renal Protection Potential and Reduces Nitric Oxide in Obese Subjects

β-1,3/1,6-D-glucan of Mycelia Extract Posses Renal Protection Potential and Reduces Nitric Oxide in Obese Subjects

Ganoderma lucidum Polysaccharide Peptide Reduces Oxidative Stress and Improves Renal Function in Patient with Cardiometabolic Syndrome

Improved production of polysaccharides in Ganoderma lingzhi mycelia by plasma mutagenesis and rapid screening of mutated strains through infrared spectroscopy

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