The effect of portacaval anastomosis on plasma lipoprotein metabolism in rats

Effect of portacaval anastomosis on hepatic HMG‐CoA‐reductase activity in normal rats

“…LDL remained unchanged. These findings are in agreement with results of Magide et al [22]. Thus, an inhibition of HMG-CoA-reductase activity by LDL, as demonstrated by Brown and Goldstein in normal fibroblasts [26], appears unlikely.…”

“…This observation is supported by results of Pector et al [21] using an in vitro technique. In contrast Magide et al [22] found an increased HMG-CoA-reductase activity. Sham-operated rats with ligated pyloric vein had a hepatic HMG-CoA-reductase activity about 53% of normal controls.…”

Portacaval Shunt and Hyperlipidemia

“…This was first observed by Winter et al 13 in normal dogs and confirmed in that species by Starzl et al, 14 Coyle et al, 15 Horak et al, 16 and Guzman et al 17 The same has been seen in rats, 18,19 pigs, 20,21 and baboons. 12 Studies in the dog 14 and investigations in the rat, 18,22 pig, 20,21 and human 23 have shown or suggested that a reduction in hepatic cholesterol or LDL synthesis or both is responsible at least in part for the falls in cholesterol levels.…”

The effect of portacaval shunt upon hepatic cholesterol synthesis and cyclic AMP in dogs and baboons

“…In rats [17,25], dogs [1][2][3][4][5][6][7][8][9][10][11][12][13]19,22,33,36], pigs [8,9], baboons [28,33], and humans [4,34,35] completely diverting portacaval shunt causes a decrease in serum cholesterol. The mechanism of this antilipidemic effect is, however, a matter of dispute.…”