The effect of potassium dichromate on convoluted tubules of the kidney of adult male albino rats and the possible protective role of ginseng

Structural Changes Induced by Potassium Dichromate in Renal Cortex of Adult Male Albino Rats and the Possible Protective Role of Selenium

“…The presence of massive interstitial hemorrhage together with congestion of blood vessels and thickening in their walls in this work was in accordance with Brzoska et al, [28] that attributed the hemorrhage to the thickening of the capillary vessels and widening of the endothelial spaces. Lenz et al, [29] clarified that mesangial cells synthesize the structural components of extracellular matrix (ECM), mainly collagen fibers and matrix metalloproteinases (MMP). Histological examination using Masson's trichrome staining of the current study showed abundant collagen fibers in the thick renal capsule, around blood vessels, renal tubules, glomeruli with extensively dense fibers around glomerular capillaries in group III.…”

Histological study on the possible protective effect of curcumin on potassium dichromate induced hypothyroidism in adult male albino rats

“…All these previous findings might be elucidated by potassium dichromate induced OS [19] and by the highly elevated TSH level in this group [6] . Others attributed potassium dichromate cytotoxicity to a combination of mechanisms including DNA damage, caspase activation, mitochondrial dysfunction and formation of ROS [10] .…”

“…Hexavalent Cr (VI) as potassium dichromate (K2Cr2O7) is much more toxic than trivalent Cr (III) as it enters cells rapidly where it is reduced by intracellular reductants to short-lived chromium intermediates. This reduction process generates ROS, causing oxidative stress (OS) and damage in many systems [10] .…”

Can constant light exposure affect the thyroid gland in prepubertal male albino rats? Histological and ultrastructural study

“…This may lead to mitochondrial dysfunction, disruption of their inner membrane with increased permeability which allowed the solute to enter the matrix and lead to its swelling, followed by rupture of the outer mitochondrial membrane and release of the pre-apoptotic proteins. El Mahalawy et al [10] reported the same finding in renal tubular cells. Zhang et al [43] added that melatonin counteracted oxidative damage of mitochondrial DNA and restored the mitochondrial respiratory control system.…”