The Effect of Povidone Iodine on Plaque and Salivary Bacteria. A Double‐blind Crossover Trial

Abstract

A double blind crossover trial was carried out to assess the effect of povidone iodine on plaque accumulation in vivo and to measure the total salivary aerobes and anaerobes throughout the study. When compared to the placebo preparation, povidone iodine was without effect on plaque accumulation in all the subjects and there was a progressive increase in plaque throughout the 10-day periods. A 30 to 40 % overall reduction in aerobes and anaerobes occurred with the active preparation which was significant. There appears to be no indication for the use of povidone iodine as an adjunct to oral hygiene or in the treatment of chronic gingivitis.

Chemical Plaque Control Strategies in the Prevention of Biofilm-associated Oral Diseases

“…The mouthwash has been shown to be effective in reducing plaque and gingivitis and may be a useful adjunct to routine oral hygiene. 50 Absorption of significant levels of iodine through the oral mucosa may make this compound unsatisfactory for prolonged use in the oral cavity.…”

Comparison of the in vivo and in vitro antibacterial properties of povidone iodine and chlorhexidine gluconate mouthrinses

“…As a mouthwash at varying con-and the implantation of organisms by local centrations, a short time 'kill' and high per-anaesthetic injections limited (Blake & Forcentage 'kill' has been demonstrated against man 1967). Despite these oral antibacterial properties, povidone iodine mouthwash appears, when compared with chlorhexidine or with a placebo preparation, to bave little or no antiplaquc activity (Saxen et al 1976, Addy et al 1977. Since tbe antiplaque activity of chlorhexidine appears to be due to tbe retention of the drug within the moutb and its subsequent slow release (Rolla et al 1970(Rolla et al , 1971, it would seem possible tbat povidone iodine is witbout such a property.…”

Reduction of potential respiratory pathogens by oral hygienic treatment in patients undergoing endotracheal anesthesia

“…Thirty minutes later, we examined the effect of cleansing on the total number of colony-forming-units (CFUs) of anaerobic organisms and C. albicans cells. All patients in the oral cleansing group performed oral rinsing with 50 ml of 0.5% povidone-iodine solution twice a day after surgery [24]. Seven days after surgery, between 9:00 and 10:00 a.m. and before oral rinsing with povidone-iodine solution, gargle samples were obtained for microbial examination.…”

“…Such biofilms are resistant to antibiotic and chemical attack [20][21][22][23]. Povidone-iodine (polyvinylpyrrolidone) is an effective broad-spectrum disinfectant that is widely used in medicine for topical applications [24,25].…”