The effect of pre-adapting light intensity on dark adaptation in early age-related macular degeneration

Gaffney, Allannah J.; Binns, Alison; Margrain, Thomas Hengist

doi:10.1007/s10633-013-9400-3

Cited by 12 publications

(15 citation statements)

References 37 publications

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“…Brown, Adams, Coletta, and Haegerstrom-Portnoy (1986) found decreased sensitivity for both rods and cones, as well as increased time constant for rod-recovery during dark adaptation in early AMD. Recent studies have provided evidence for AMD related increases in the time constant for cone recovery (Gaffney, Binns, & Margrain, 2011; Gaffney, Binns, & Margrain, 2013), delayed rod-cone break (Dimitrov, Guymer, Zele, Anderson, & Vingrys, 2008; Gaffney et al, 2011; Gaffney et al, 2013; Owsley, Jackson, White, Feist, & Edwards, 2001), and delayed rod recovery (Brown et al, 1986; Dimitrov et al, 2008; Dimitrov et al, 2011; Owsley et al, 2001). Impaired dark adaptation has been found in different retinal locations (Gaffney et al, 2011; Steinmetz, Haimovici, Jubb, Fitzke, & Bird, 1993) and at different bleach levels (Dimitrov et al, 2008; Gaffney et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Efficient assessment of the time course of perceptual sensitivity change

2019

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Perceptual sensitivity is usually estimated over trials and time intervals, which results in imprecise and biased estimates when it changes rapidly over time. We develop a novel procedure, the quick Change-Detection (qCD) method, to accurately, precisely, and efficiently assess the time course of perceptual sensitivity change. Based on Bayesian adaptive testing, qCD selects the optimal stimulus, and updates, trial by trial, a joint probability distribution of the parameters that quantify perceptual sensitivity change over time. We demonstrate the utility of the method in measuring the time course of dark adaptation. Simulations showed that the accuracy and precision of the estimated dark adaptation curve after one qCD run (root mean squared error (RMSE): 0.002; the half width of the 68.2% credible interval (HWCI): 0.016; standard deviation (SD): 0.020; all in log10 units) was higher than those obtained by ten runs of the quick Forced-Choice (qFC) procedure (RMSE: 0.020; HWCI: 0.032; SD: 0.031) and ten runs of a weighted up-down staircase procedure (RMSE: 0.026; SD: 0.031). Further, the dark adaptation curve obtained from one qCD run in a psychophysics experiment was highly consistent with the average of four qFC runs (RMSE = 0.076 log10 units). Overall, the qCD may provide a procedure to characterize the time course of perceptual sensitivity change in both basic research and disease progression and treatment.

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Section: Introductionmentioning

confidence: 99%

Efficient assessment of the time course of perceptual sensitivity change

2019

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“…It is well known that deficits in rod-mediated retinal function occur as a natural consequence of normal aging [ 36 , 49 , 50 , 51 , 52 ] a process that may be accelerated in age-related macular degeneration (AMD) [ 34 , 38 , 39 , 49 , 53 , 54 , 55 , 56 ]. There are numerous psychophysical studies that have demonstrated decreases in rod-mediated sensitivity and prolonged dark-adaptation kinetics even in early AMD [ 33 , 34 , 36 , 38 , 39 , 54 , 55 , 56 , 57 , 58 , 59 ]. Thus, many have proposed scotopic thresholds as a potential endophenotype.…”

Section: Introductionmentioning

confidence: 99%

Endophenotypes for Age-Related Macular Degeneration: Extending Our Reach into the Preclinical Stages of Disease

Gorin¹,

Weeks

Baron

et al. 2014

JCM

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The key to reducing the individual and societal burden of age-related macular degeneration (AMD)-related vision loss, is to be able to initiate therapies that slow or halt the progression at a point that will yield the maximum benefit while minimizing personal risk and cost. There is a critical need to find clinical markers that, when combined with the specificity of genetic testing, will identify individuals at the earliest stages of AMD who would benefit from preventive therapies. These clinical markers are endophenotypes for AMD, present in those who are likely to develop AMD, as well as in those who have clinical evidence of AMD. Clinical characteristics associated with AMD may also be possible endophenotypes if they can be detected before or at the earliest stages of the condition, but we and others have shown that this may not always be valid. Several studies have suggested that dynamic changes in rhodopsin regeneration (dark adaptation kinetics and/or critical flicker fusion frequencies) may be more subtle indicators of AMD-associated early retinal dysfunction. One can test for the relevance of these measures using genetic risk profiles based on known genetic risk variants. These functional measures may improve the sensitivity and specificity of predictive models for AMD and may also serve to delineate clinical subtypes of AMD that may differ with respect to prognosis and treatment.

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“…Dimitrov et al [15,41] assessed using both techniques. Eight studies used an adapted Humphrey Visual Field Perimeter (HVFP; Carl Zeiss Meditec, Inc, Dublin, CA, USA) [43][44][45][46][47][48][49][50] and eight utilised an 'in-house' adaptometer, with methods developed by investigators [15,41,42,[61][62][63][64][65]. Other adaptometers, featured in more than one study, included the Medmont Dark Adapted Chromatic perimeter (MDAC; Medmont Pty Ltd, Melbourne, Australia) (5 out of 27 studies) [55][56][57][58][59] and the Macular Disease Detection MDD-2 Ò device (Health Research Science, LLC, Lighthouse Pt, FL, USA) (2 out of 27 studies) [53,54].…”

Section: Other Adaptometers and Photostress Testsmentioning

confidence: 99%

“…The most frequently reported parameters of DA in studies that did not use the AdaptDx were RCB (10 out of 27 studies) [41, 42, 44-48, 60, 63, 65], cone absolute threshold (9 out of 27 studies) [41, 42, 44-48, 63, 65], cone time constant (8 out of 27 studies) [44][45][46][47][48][49][50]65] and RIT/ rod criterion time (7 out of 27 studies) [41,[55][56][57][58][59]63]. Other parameters in the reviewed papers included rod absolute threshold (5 out of 27 studies) [41,[46][47][48]63] and 'second slope' or rod slope (5 out of 27 studies) [42,[46][47][48]65], which refers to the second phase of rod recovery when threshold data are fitted with a model based on the physiological process of DA [7].…”

Section: Other Adaptometers and Photostress Testsmentioning

confidence: 99%

Are Current Methods of Measuring Dark Adaptation Effective in Detecting the Onset and Progression of Age-Related Macular Degeneration? A Systematic Literature Review

et al. 2021

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Introduction: Dark adaptation (DA) has been proposed as a possible functional biomarker for age-related macular degeneration (AMD). In this systematic review we aim to evaluate current methodology used to assess DA in people with AMD, the evidence of precision in detecting the onset and progression of AMD, and the relationship between DA and other functional and structural measures. Methods: MEDLINE, EMBASE, CINAHL, AMED, PsycINFO, PsycARTICLES were searched for studies published between January 2006 and January 2020 that assessed DA in people with AMD. Details of eligible studies including study design, characteristics of study population and outcomes were recorded. All included studies underwent quality appraisal using approved critical appraisal tools. This systematic review follows PRISMA guidelines (PROSPERO registration number: CRD42019129486). Results: Forty-eight studies were eligible for inclusion, reporting a variety of instruments and protocols to assess different DA parameters. Twenty of these studies used the AdaptDx (MacuLogix, Hummelstown, PA, USA) instrument and assessed rod-intercept time (RIT). Most of these reported that RIT was delayed in people with AMD and this delay worsened with AMD severity. Four studies, involving 533 participants, reported estimates of diagnostic performance of AdaptDx to separate people with AMD from visually healthy controls. DA has been compared to other measures of visual function, patient-reported outcome measures (PROMs) and structural measures. Ten studies specifically considered evidence that the presence of certain structural abnormalities was associated with impaired DA in AMD. Conclusions: This systematic review indicates overwhelming evidence of reasonable quality for an association between impaired DA and AMD. Data on the repeatability and reproducibility of DA measurement are sparse. There is evidence that structural abnormalities such as reticular drusen are associated with prolongation of DA time. Fewer studies have explored an association between DA and other measures of visual function or PROMs. We found no studies that had compared DA with performance-based measures.

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The effect of pre-adapting light intensity on dark adaptation in early age-related macular degeneration

Abstract: This is the accepted version of the paper.This version of the publication may differ from the final published version. Permanent AbstractBackground: This study aimed to identify the pre-adapting light intensity that generated the

Cited by 12 publications

References 37 publications

Efficient assessment of the time course of perceptual sensitivity change

Efficient assessment of the time course of perceptual sensitivity change

Endophenotypes for Age-Related Macular Degeneration: Extending Our Reach into the Preclinical Stages of Disease

Are Current Methods of Measuring Dark Adaptation Effective in Detecting the Onset and Progression of Age-Related Macular Degeneration? A Systematic Literature Review

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