The Effect of Pregabalin Versus Carbamazepine on the Gingiva of Albino Rats With the Possible Modulatory Action of Acasia Arabica.

Abstract

The aim of this study was to compare the effect of anticonvulsant Pregabalin versus Carbamazepine, with and without Acacia Arabica on the rats ' gingiva. Materials and methods: 35 adult male albino rats were divided into: control group contained seven rats received distilled water for three weeks, experimental group I contained seven rats received Carbamazepine (20 mg/kg), subgroup I contained seven rats which received Carbamazepine (20 mg/kg) and Acasia Arabica (100 mg/kg), group II contained seven rats received Pregabaline (20 mg/kg) and subgroup II contained seven rats received Pregabaline (20 mg/kg) and Acasia Arabica (100 mg/kg). After three weeks, all rats were terminated and the mandibular molar regions were excised, fixed then decalcified and stained with H & E. The epithelium thickness was measured using morphometric analysis and the gingival specimens were examined for the expression of Ki-67 antigen. Results: The side effects on the gingiva either histologically or immuno histochemically were severe with Carbamazepine and mild with Pregabalin. Results also showed a great modulating effect of Acacia Arabica on the enlarged gingiva. Conclusion: Pregabalin treatment has milder deletarious effects on the gingiva when compared with Carbamazepine.