The effect of premature ovarian insufficiency on nasal mucociliary clearance time

Karaer, Işıl Çakmak; Tuncay, Görkem

doi:10.1080/09513590.2019.1631275

Cited by 4 publications

(4 citation statements)

References 16 publications

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“…Impact of sex hormones on the nasal mucosa has been shown by previous researchers in various physiological, iatrogenic or pathological conditions. 3 , 5 , 6 , 7 , 13 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 Almost all concluded that E2 and PG causes obstruction and edema in the nasal cavity which is the case in this study ( Fig. 2 b).…”

Section: Discussionsupporting

confidence: 67%

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Role of VPAC1 and VPAC2 receptors in the etiology of pregnancy rhinitis: an experimental study in rats

Ülkümen

Batır

Pala

et al. 2022

Brazilian Journal of Otorhinolaryngology

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Section: Discussionsupporting

confidence: 67%

“…In addition, the impact of sex hormones on nasal mucosa has been studied in various aspects. 15 , 16 , 17 , 18 , 19 , 20 But there is very limited data regarding histopathological and biomolecular changes in the nasal mucosa of patients having PR. 21 , 22 …”

Section: Introductionmentioning

confidence: 99%

Role of VPAC1 and VPAC2 receptors in the etiology of pregnancy rhinitis: an experimental study in rats

Ülkümen

Batır

Pala

et al. 2022

Brazilian Journal of Otorhinolaryngology

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“…But a common biomolecular pathway for allergy and PR cannot be revealed yet. In addition, the effect of gonadocorticoids on the nasal mucosa has been studied in the context of various gynecological disorders [13][14][15][16] . However, there is very limited data about biomolecular changes regarding PR 17,18 .…”

Section: Introductionmentioning

confidence: 99%

“…It is well-known fact that these two gonadocorticoids exhibit a gradual increase during gestation 3 . In addition, effect of gonadocorticoids on nasal mucosa has been revealed in various aspects [31][32][33][34][35][36] . Considering these findings, we hypothesized that nasal TREK1 and AQP5 expression would be up regulated by increased serum levels of E2 and PG during pregnancy.…”

Section: Introductionmentioning

confidence: 99%

Role of Nasal AQP5 And TREK1 Expression in Biomolecular Background of Pregnancy Rhinitis

Ülkümen¹

2020

jamp

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Pregnancy rhinitis may lead predisposition to Obstructive Sleep Apnea Syndrome which is associated with critical comorbidities effecting both mother (preeclampsia, hypertension) and newborn (intrauterine growth retardation, low apgar score). We aim to unveil if nasal TREK-1 and AQP5 expression changes during pregnancy. We proposed that these two proteins may take part in the biomolecular background of Pregnancy Rhinitis. Twenty adult Wister albino female rats were enrolled into the study. Two groups constituted as 10 control (group A) and 10 pregnant (group B) rats. We sacrificed the rats at 21th day of gestation by intraperitoneal injection of 400mg/kg Na-pentobarbitone. Intracardiac blood sample was taken before the pulse died out. Serum estradiol (E2) and progesterone (PG) levels were determined by ELISA. Nasal septum with its mucoperichondrium was resected and sent for real time polymerase chain reaction testing. Relative TREK-1 (p=0.001) expression of group B was found to be significantly higher than group A. Relative AQP5 (p=0.003) expression was also found to be significantly higher in group B than group A. E2 was found to upregulate AQP5 expression (p=0.032) while downregulate TREK1 expression (p=-0.011). On the other hand, PG was also found to upregulate nasal AQP5 expression (p=0.024) but not TREK1 expression (p=-0.071). TREK1 and AQP5 take part in pregnancy related biomolecular changes of nasal mucosa. Namely, expression of TREK1 decreases while expression of AQP5 increases during pregnancy. These findings support the researchers asserting triggered allergy as the etiology of PR.

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Effects of rapid maxillary expansion or alternating rapid maxillary expansion and constriction on nasal mucociliary clearance

et al. 2021

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The effect of premature ovarian insufficiency on nasal mucociliary clearance time

Cited by 4 publications

References 16 publications

Role of VPAC1 and VPAC2 receptors in the etiology of pregnancy rhinitis: an experimental study in rats

Role of VPAC1 and VPAC2 receptors in the etiology of pregnancy rhinitis: an experimental study in rats

Role of Nasal AQP5 And TREK1 Expression in Biomolecular Background of Pregnancy Rhinitis

Effects of rapid maxillary expansion or alternating rapid maxillary expansion and constriction on nasal mucociliary clearance

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