The effect of prenatal maternal distress on offspring brain development: A systematic review

Mandl, Sophie; Alexopoulos, Johanna; Doering, Stephan; Wildner, Brigitte; Seidl, Rainer; Bartha-Doering, Lisa

doi:10.1016/j.earlhumdev.2024.106009

Early Human Development

2024

DOI: 10.1016/j.earlhumdev.2024.106009

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The effect of prenatal maternal distress on offspring brain development: A systematic review

Sophie Mandl,

Johanna Alexopoulos,

Stephan Doering

et al.

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2024

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Cited by 3 publications

References 89 publications

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Special Issue “Biological and Psychological Perspectives”: Guest editorial

Fink,

Manning

2024

Early Human Development

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Special Issue “Biological and Psychological Perspectives”: Guest editorial

Fink,

Manning

2024

Early Human Development

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Prenatal exposures and cell type proportions are main drivers of FKBP5 DNA methylation in maltreated and non-maltreated children

Karlbauer,

Martins,

Rex-Haffner

et al. 2024

Neurobiology of Stress

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Kidney Programming and Hypertension: Linking Prenatal Development to Adulthood

Tain,

Hsu

2024

IJMS

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The complex relationship between kidney disease and hypertension represents a critical area of research, yet less attention has been devoted to exploring how this connection develops early in life. Various environmental factors during pregnancy and lactation can significantly impact kidney development, potentially leading to kidney programming that results in alterations in both structure and function. This early programming can contribute to adverse long-term kidney outcomes, such as hypertension. In the context of kidney programming, the molecular pathways involved in hypertension are intricate and include epigenetic modifications, oxidative stress, impaired nitric oxide pathway, inappropriate renin–angiotensin system (RAS) activation, disrupted nutrient sensing, gut microbiota dysbiosis, and altered sodium transport. This review examines each of these mechanisms and highlights reprogramming interventions proposed in preclinical studies to prevent hypertension related to kidney programming. Given that reprogramming strategies differ considerably from conventional treatments for hypertension in kidney disease, it is essential to shift focus toward understanding the processes of kidney programming and its role in the development of programmed hypertension.

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The effect of prenatal maternal distress on offspring brain development: A systematic review

Cited by 3 publications

References 89 publications

Special Issue “Biological and Psychological Perspectives”: Guest editorial

Special Issue “Biological and Psychological Perspectives”: Guest editorial

Prenatal exposures and cell type proportions are main drivers of FKBP5 DNA methylation in maltreated and non-maltreated children

Kidney Programming and Hypertension: Linking Prenatal Development to Adulthood

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