The Effect of Preoperative Radiotherapy Upon Tumor Volume in Rectal Carcinoma

Abstract

We studied an effect of preoperative radiation upon the change of tumor volume in rectal carcinomas. As a preliminary study, tumor volume of 15 cases of rectal carcinoma with no preoperative irradiation was estimated preoperatively using transrectal ultrasonography, and were compared with those determined by resected specimens after operation. As a result, there was a pallarel relasionship between the two values, and a mean estimation error rate was 14.6%. Next, the same method was applied to 15 patients with rectal carcinoma who underwent preoperative radiation in order to detect the reduction rate of tumor volume after radiation therapy (42.6 Gy). As a consequence, 80% of cases exhibited the reduction rate of more than 40% with an average of 55.1%. It was suggested that the determination of pre and postoperative tumor volume would be beneficial to evaluation of preoperative radiation therapy as well as decision of the optimal dose of radiation in rectal carcinomas.

Control of treatment size in cavitation-enhanced high-intensity focused ultrasound using radio-frequency echo signals

“…For example, a few hundred HIFU shots are needed to treat a tumor of 30 cm 3 volume because a typical HIFU shot at 1 MHz can treat only a tumor of 0.1 cm 3 volume. 3) Another problem is the deviation of treatment size between HIFU shots at the same ultrasonic dose. 4) One of the possible reasons for the deviation is the differences in ultrasonic attenuation and absorption between each HIFU target tissue and intervening tissues.…”