The Effect of Prescribed Daily Dose Frequency on Patient Medication Compliance

Eisen, Seth A.; Miller, Douglas K.; Woodward, Robert S.; Spitznagel, Edward; Przybeck, Thomas R.

doi:10.1001/archinte.1990.00390200073014

Cited by 658 publications

(200 citation statements)

References 13 publications

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“…This result partly supported the hypothesis that reduced call frequency would be associated with increased rates of compliance. Thus with the relaxed window, the overall (numerically) highest rate of compliance was observed with the OD schedule -consistent with the theory that once-daily dosing is superior to more frequent dosing regimens [13][14][15][16][17]. Indeed, the rate of completed calls within the relaxed window was considerably higher (38% to 60%) for the OD schedule than for the TID schedule.…”

Section: Discussionsupporting

confidence: 77%

“…IVRS acted as a suitable model of medication dosing since, in accordance with the literature, OD dosing was associated with improved compliance compared with BID or TID dosing [13][14][15][16][17]. A key advantage of this model is that the selected SRT and CRT modules took approximately 2 minutes each to complete -simulating the time required to take a dose of medication.…”

Section: Discussionmentioning

confidence: 99%

“…There is some evidence (although inconsistent) that reducing dosing frequency may enhance compliance [13][14][15][16][17]. However, this evidence generally comes from Page 7 of 25…”

Section: Introductionmentioning

confidence: 99%

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A randomized trial to determine the impact on compliance of a psychophysical peripheral cue based on the Elaboration Likelihood Model

Horton

Minniti

Mireylees

et al. 2008

Contemporary Clinical Trials

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Objective: Non-compliance in clinical studies is a significant issue, but causes remain unclear.Utilizing the Elaboration Likelihood Model of persuasion, this study assessed the psychophysical peripheral cue 'Interactive Voice Response System (IVRS) call frequency' on compliance.Methods: 71 participants were randomized to once daily (OD), twice daily (BID) or three times daily (TID) call schedules over two weeks. Participants completed 30-item cognitive function tests at each call.Compliance was defined as proportion of expected calls within a narrow window (±30 min around scheduled time), and within a relaxed window (-30 min to +4 hour). Data were analyzed by ANOVA and pairwise comparisons adjusted by the Bonferroni correction.Results: There was a relationship between call frequency and compliance. Bonferroni adjusted pairwise comparisons showed significantly higher compliance (p=0.03) for the BID (51.0%) than TID (30.3%) for the narrow window; for the extended window, compliance was higher (p=0.04) with OD (59.5%), than TID (38.4%).Conclusion: The IVRS psychophysical peripheral cue call frequency supported the ELM as a route to persuasion. The results also support OD strategy for optimal compliance. Models suggest specific indicators to enhance compliance with medication dosing and electronic patient diaries to improve health outcomes and data integrity respectively.Response to Reviewers: Sincerest thanks to the reviewers for providing feedback. Each comment has been addressed either in the manuscript or is shown below. 2. 'Participants (N=71), were randomized using an IVRS in the ratio 1:1:1 to a OD, BID or TID call schedule'.How did authors divide them according to 1:1:1? Explanatory text has been added to page 8. Please note that randomization was not stratified.3. '44 (62%) completed the study (Fig.1). Participants who prematurely discontinued were not followed up, so reasons for withdrawal are unknown'. Just 44 of 71 participants completed study, the quality of it should be susceptible.The authors recognize that the completion rate is lower than perhaps might be considered ideal. However it should be noted that 78% of participants randomized to once-daily calls completed the study compared to 43% of participants randomized to three-times daily calls. This difference in completion rates supports our findings for the primary endpoint, given that the once-daily call schedule was associated with the highest rate of compliance (with the relaxed window). Additional text has been added to the discussion (page 16) to raise this point.4. The discussion should be concise; the conclusion should be cautious.The discussion and conclusion have been shortened, to ensure that only the key points from the study are discussed, and to remove some of the aspects of the conclusions that generalised the findings of the study in a clinical study context. See pages 15-20.Reviewer 2 Define "electronic patient diaries "A definition has been added to page 5. Define "Interactive Voice Response systems "A definition has ...

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Section: Discussionsupporting

confidence: 77%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

A randomized trial to determine the impact on compliance of a psychophysical peripheral cue based on the Elaboration Likelihood Model

Horton

Minniti

Mireylees

et al. 2008

Contemporary Clinical Trials

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“…Studies in civilian populations have indicated that physicians can expect 73-83% compliance when patients are prescribed one-time daily dosing. 17,18 The compliance rate for one-time weekly dosing was worse (38%). Army researchers have also reported that MSM compliance with chemoprophylaxis is "notoriously low" 19 but did not cite their evidence.…”

Section: Discussionmentioning

confidence: 99%

Compliance with Antimalaria Chemoprophylaxis in a Combat Zone

Brisson¹,

Brisson²

2012

The American Society of Tropical Medicine and Hygiene

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Abstract. Compliance with malaria chemoprophylaxis by military service members (MSMs) is notoriously low, ranging from 30% to 56%. Our objective was to determine the rate of compliance and reasons for non-compliance with malaria chemoprophylaxis among healthy US MSMs in Afghanistan. An eight-question, anonymous online survey was used to collect data regarding the compliance of healthy MSMs with malaria chemoprophylaxis. E-mail surveys were sent to 1,200 MSMs; 528 (44%) MSMs completed the survey. One-time daily doxycycline was the most commonly prescribed chemoprophylaxis (90%); 60% (N = 318) responded that they were compliant with their chemoprophylaxis as prescribed, whereas 40% (N = 221) indicated that they were not compliant. Compliance with daily dosing was 61% and weekly dosing was 38%. The most common reasons for non-compliance were gastrointestinal effects (39%), forgetfulness (31%), and low perception of risk (24%). Malaria chemoprophylaxis compliance by healthy MSMs in Afghanistan is poor. Side effects, forgetfulness, and lack of education are contributing factors. Commanders bear the primary responsibility for the health of their soldiers, and the individual MSM bears personal responsibility; however, additional public health interventions could possibly have a positive impact on prevention.

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“…36 Doctors also want to try and limit the number of doses; indeed the risk of decreased adherence due to an increase in the number of daily doses is well recognized. 37 Blood pressure measurement outside the office The numerous sources of error associated with the clinical measurement of BP justify self-measure or ABPM in the event of an apparently poor response to antihypertensive treatment.…”

Section: Management Of Resistance To Combined Therapymentioning

confidence: 99%

Management in general practice of hypertensive patients poorly controlled with a fixed-dose renin–angiotensin system inhibitor and diuretic combination: results from a French national survey

et al. 2006

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High rates of uncontrolled hypertensives have been reported in France as well as in other countries, partly owing to an inadequate management of hypertension by clinicians. The objectives of the study were (1) to describe the therapeutic decisions faced by general practitioners (GP) in hypertensives not controlled by fixed-dose combination antihypertensive therapy with a renin-angiotensin system (RAS) inhibitor and a diuretic (D) and (2) to evaluate the frequency with which ambulatory blood pressure monitoring (ABPM) is used in these patients. Each GP had to include five uncontrolled hypertensives on fixed-dose RAS inhibitor and D combination. A total of 2118 GPs included 9551 patients; 8643 patients were receiving at least one of the two drugs at a low dose (group 1) and the remaining 908 patients were receiving high doses of both drugs (group 2). The most common therapeutic choice was that of a new combination, either a fixed-dose in one pill or with separate preparations: 65% (n ¼ 5621) in group 1 and 56% (n ¼ 505) in group 2. An increase in dose was chosen in 28% of patients in group 1 (n ¼ 2467) and continuation of treatment without modification in 27% of patients in group 2 (n ¼ 242). A third active principle was only added in 2.5% of patients in group 1 (n ¼ 219) and 11% in group 2 (n ¼ 103). Ambulatory blood pressure monitoring was employed in 25% of patients (n ¼ 2413). An improvement in hypertension management should be expected from the implementation of the 2005 French guidelines.

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The Effect of Prescribed Daily Dose Frequency on Patient Medication Compliance

Cited by 658 publications

References 13 publications

A randomized trial to determine the impact on compliance of a psychophysical peripheral cue based on the Elaboration Likelihood Model

A randomized trial to determine the impact on compliance of a psychophysical peripheral cue based on the Elaboration Likelihood Model

Compliance with Antimalaria Chemoprophylaxis in a Combat Zone

Management in general practice of hypertensive patients poorly controlled with a fixed-dose renin–angiotensin system inhibitor and diuretic combination: results from a French national survey

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