The Effect of Pretreatment With Toll-Like Receptor 4 Antagonist Resatorvid on Methotrexate-Induced Liver Injury in Rats: Histopathological Study

Mohammad, Bassim I; Ahmed, Bassim S; Hassan, Alaa Fadhel; Hassan, Samer F.

doi:10.22159/ajpcr.2018.v11i12.29939

Cited by 3 publications

(2 citation statements)

References 38 publications

(71 reference statements)

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“…These changes were attributed to MTX-induced increases in both oxidative and nitrosative stress because of exposure of the liver to high concentrations of MTX oxidative metabolites. Inhibition of the cytosolic de novo synthetic pathway for purines, pyrimidines, and polyamines by methotrexate reduces hepatic folate reservoirs, limits folate entry into mitochondria, and affects S-phase nucleic acid synthesis [27].…”

Section: Discussionmentioning

confidence: 99%

Effectiveness and Side Effects of Using Methotrexate and Adalimumab in the Treatment of Rheumatoid Arthritis Patients

Kamri¹,

AZIZAH²,

AVISTA³

2023

Int J App Pharm

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Rheumatoid arthritis (RA) is one of the diseases autoimmune systemic progressively characterized by inflammation of the membrane synovial that coating joints. Methotrexate (MTX) and Adalimumab are one of the drugs that are commonly used in Rheumatoid arthritis treatment. This study is aimed to look at the effectiveness and safety of both either in monotherapy and a combination of them. This study is a review of the article of experimental studies with data retrieval retrospectively on a database that has been set, namely PubMed, Google Scholar, and Portal Garuda were conducted for 6 mo. The use of adalimumab showed improvement based on the value DAS28-4(ESR) and HAQ-DI when compared with methotrexate. The side effects caused by MTX showed the risk was more than 2% than adalimumab. Several drug carriers are determinants of therapeutic efficacy, such as sRNA (small interfering-RNA), LPNP (hybrid lipid-polymers nanoparticles), FRβ (Folate-receptor β), NF-κB (nuclear factor kappa-light-chain-enhancer of activated B-cells), β-GP (β-Glycerophosphate). The use of adalimumab monotherapy has slightly better effectiveness than methotrexate but has more diverse side effects but less risk. The use of the combination does not have a significant difference, but the risk of side effects from both is lower than when used alone.

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Section: Discussionmentioning

confidence: 99%

Effectiveness and Side Effects of Using Methotrexate and Adalimumab in the Treatment of Rheumatoid Arthritis Patients

Kamri¹,

AZIZAH²,

AVISTA³

2023

Int J App Pharm

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“…Group 4 [Gentamicin + Resatorvid (n:7)]: Gentamicin (80 mg/kg, intraperitoneal) and resatorvid (5 mg/kg, intraperitoneal) were administered for 8 days 17,18 .…”

Section: Experimental Designmentioning

confidence: 99%

Potential effects of Resatorvid and Alpha Lipoic Acid on gentamicin-induced nephrotoxicity in rats

HATİPOĞLU,

DiK,

ATEŞ

2023

Preprint

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Gentamicin (GM) is an aminoglycoside antibiotic with a rapid bactericidal effect in the treatment of many infections. However, its use in high concentrations for more than 7 days causes nephrotoxic side effects. It was aimed to determine the biochemical and molecular activities of resatorvid and alpha lipoic acid (ALA) on GM induced nephrotoxicity in rats. In the study, 34 Wistar albino rats were randomly distributed; Healthy control (n:6), Gentamicin (80 mg/kg, n:7), Gentamicin+Sham (%10 hydroalcoholic solution, n:7), Gentamicin+resatorvid (5 mg/kg, n:7), Gentamicin+ALA (100 mg/kg, n:7). Urinary IL-18, KIM-1 and NGAL levels were statistically decreased by resatorvid treatment, and KIM-1 levels were statistically decreased by ALA treatment compared to the gentamicin group. In addition, urine creatinine was partially decreased by resatorvid and ALA. NRF-2, CAS-3 and NR4A2 expressions were statistically decreased by resatorvid and ALA treatment. Nevertheless, NF-κB was statistically decreased only with resatorvid. The nephrotoxicity that limits the use of gentamicin in infections can reduce by resatorvid in the future. Therefore, it can be used for a longer and more effective in infections.

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Potential effects of Resatorvid and alpha lipoic acid on gentamicin‐induced nephrotoxicity in rats

Dik,

Hatipoglu,

Ates

2024

Pharmacology Res & Perspec

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Gentamicin is an aminoglycoside antibiotic with a rapid bactericidal effect on the treatment of many infections. However, its use at high concentrations for more than 7 days causes nephrotoxic side effects. This study investigated the potential of Resatorvid and alpha lipoic acid (ALA) in mitigating gentamicin‐induced nephrotoxicity in rats, considering biochemical, histopathological, and molecular parameters. This study randomly distributed 34 Wistar albino rats into four groups: healthy control (n = 6), Gentamicin (80 mg/kg, n = 7), Gentamicin + Sham (%10 hydroalcoholic solution, n = 7), Gentamicin + Resatorvid (5 mg/kg, n = 7), and Gentamicin + ALA (100 mg/kg, n = 7). Resatorvid treatment led to a statistically significant decrease in urinary IL‐18, KIM‐1, and NGAL levels, whereas ALA treatment significantly reduced KIM‐1 levels compared to the gentamicin‐only group. Both Resatorvid and ALA showed partial reductions in urine creatinine levels. Moreover, treatments with Resatorvid and ALA resulted in statistically significant decreases in NRF‐2, CAS‐3, and NR4A2 expressions. However, only Resatorvid demonstrated a statistically significant decrease in NF‐B expression. These findings highlight the potential of Resatorvid in ameliorating gentamicin‐induced nephrotoxicity, thereby expanding the therapeutic utility of gentamicin and enhancing its efficacy against infections.

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The Effect of Pretreatment With Toll-Like Receptor 4 Antagonist Resatorvid on Methotrexate-Induced Liver Injury in Rats: Histopathological Study

Cited by 3 publications

References 38 publications

Effectiveness and Side Effects of Using Methotrexate and Adalimumab in the Treatment of Rheumatoid Arthritis Patients

Effectiveness and Side Effects of Using Methotrexate and Adalimumab in the Treatment of Rheumatoid Arthritis Patients

Potential effects of Resatorvid and Alpha Lipoic Acid on gentamicin-induced nephrotoxicity in rats

Potential effects of Resatorvid and alpha lipoic acid on gentamicin‐induced nephrotoxicity in rats

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