The Effect of Preweaning Undernutrition upon the Sexual Development of Male Mice

Jean‐Faucher, Ch.; Berger, Michel; Turckheim, M. de; Veyssière, G.; Jean, Cl.

doi:10.1159/000241515

Cited by 11 publications

(3 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The sexual maturation in male mice was reported to be 36-46 days (mean age: 40.6 ± 0.6) [37]. Therefore, the male offspring were sacrificed at PND 45 for measuring the various parameters indicating testis development.…”

Section: Discussionmentioning

confidence: 99%

Impact of bisphenol-A on the spliceosome and meiosis of sperm in the testis of adolescent mice

Wang

Zhang

2022

BMC Vet Res

View full text Add to dashboard Cite

Background Bisphenol-A (BPA) has estrogenic activity and adversely affects humans and animals' reproductive systems and functions. There has been a disagreement with the safety of BPA exposure at Tolerable daily intake (TDI) (0.05 mg/kg/d) value and non-observed adverse effect level (5 mg/kg/d). The current study investigated the effects of BPA exposure at various doses starting from Tolerable daily intake (0.05 mg/kg/d) to the lowest observed adverse effect level (50 mg/kg/d) on the testis development in male mice offspring. The BPA exposure lasted for 63 days from pregnancy day 0 of the dams to post-natal day (PND) 45 of the offspring. Results The results showed that BPA exposure significantly increased testis (BPA ≥ 20 mg/kg/d) and serum (BPA ≥ 10 mg/kg/d) BPA contents of PND 45 mice. The spermatogenic cells became loose, and the lumen of seminiferous tubules enlarged when BPA exposure at 0.05 mg/kg/d TDI. BPA exposure at a low dose (0.05 mg/kg/d) significantly reduced the expression of Scp3 proteins and elevated sperm abnormality. The significant decrease in Scp3 suggested that BPA inhibits the transformation of spermatogonia into spermatozoa in the testis. The RNA-seq proved that the spliceosome was significantly inhibited in the testes of mice exposed to BPA. According to the RT-qPCR, BPA exposure significantly reduced the expression of Snrpc (BPA ≥ 20 mg/kg/d) and Hnrnpu (BPA ≥ 0.5 mg/kg/d). Conclusions This study indicated that long-term BPA exposure at Tolerable daily intake (0.05 mg/kg/d) is not safe because low-dose long-term exposure to BPA inhibits spermatogonial meiosis in mice testis impairs reproductive function in male offspring.

show abstract

Section: Discussionmentioning

confidence: 99%

Impact of bisphenol-A on the spliceosome and meiosis of sperm in the testis of adolescent mice

Wang

Zhang

2022

BMC Vet Res

View full text Add to dashboard Cite

show abstract

“…For example in men with idiopathic hypogonadotropic hypogonadism (IHH), a congenital hypothalamic inability to transcribe and secrete GnRH, patients who are exposed to endogenous GnRH during adolescence are more responsive to postadolescent GnRH treatment (Spratt and Crowley, 1988). Testicular function has also been shown to be permanently altered by preadolescent undernutrition in mice (Jean-Faucher et al, 1982). Adolescent priming may also underlie population variation in ovarian function (Ellison, 1997).…”

Section: Discussionmentioning

confidence: 99%

Serum leptin levels and anthropometric correlates in Ache Amerindians of eastern Paraguay

Bribiescas

2001

American J Phys Anthropol

View full text Add to dashboard Cite

Leptin is a recently discovered peptide hormone secreted primarily from adipocytes in humans and other mammals; it is a reflection of fat stores, and has been associated with reproductive function. However, few leptin measurements are available from nonindustrialized populations, including contemporary hunter/gatherer communities undergoing the transition to sedentary agriculture. This investigation reports single-sample serum leptin measurements in healthy Ache Amerindian males (n = 21; average age, 32.8 +/- 3.4 SE) and females (n = 12; average age, 31.3 +/- 4.3) in eastern Paraguay. Ache leptin concentrations were much lower than in industrialized populations, although significant sexual dimorphism was evident (female 5.64 ng/ml +/- 0.91 SE vs. male 1.13 ng/ml +/- 0.08; P < 0.0001). Indeed, female leptin levels were similar to those of anorexic women, despite apparently adequate adiposity. Controlling for fat percentage, no significant sex difference was evident, suggesting that adiposity was the primary source of leptin variation. Body fat percentage was highly correlated with leptin in females (r2 = 0.72; P < 0.0005) but not males, who exhibited a modest negative correlation (r2 = 0.25; P < 0.03). Weight (r2 = 0.45; P = 0.02) and BMI (kg/m2) (r2 = 0.81; P < 0.0001) were also significantly correlated in females but not males. These results suggest that: 1) clinical leptin norms based on industrialized populations may represent the highest range of human variation and may not be representative of most human populations; 2) hormonal priming may underlie population variation in leptin profiles; and 3) the relative importance of leptin as a proximate mechanism regulating reproductive effort during human evolution may have been modest.

show abstract

“…Ellison (1997) proposed that environmental conditions affecting energy availability during human female puberty may underlie variation in adult ovarian function. While the role of hormonal priming in male adolescents remains to be fully elucidated, variation in HPT function and pubertal development in association with energy availability has been documented in rodents, nonhuman primates, and humans (Cameron, 1991;Dubey et al, 1986;Jean-Faucher et al, 1982;Kulin, 1996;Kulin et al, 1982Kulin et al, , 1984. Kulin et al (1984) reported that undernourished Kenyan male adolescents exhibited delayed pubertal LH and FSH increases compared to well-fed controls living in affluent neighborhoods of Nairobi.…”

Section: Reproductive Endocrinologymentioning

confidence: 99%

Reproductive ecology and life history of the human male

Bribiescas

2001

Am. J. Phys. Anthropol.

211

117

View full text Add to dashboard Cite

Until recently, the reproductive ecology of human males has not been extensively investigated, primarily as a result of the need for a theoretical framework based on the reproductive constraints and energetics of mammalian males. More specifically, male reproductive ecology has necessitated an integrative interpretation of clinical and anthropological data based on the premise that the evolution of human male life histories has involved selection for physiological mechanisms aimed at optimizing trade-offs between survivorship and reproductive effort. This paper attempts to address this gap in our understanding by presenting the current state of male reproductive ecology, including physiologic data from clinical and anthropological investigations as well as recent theoretical developments. Recent investigations outlining population variation in reproductive endocrine function are discussed within the context of potential sources of variation, including energetic expediture, caloric intake, and developmental canalization during adolescence. Additional summaries of male senescence and behavior are presented to provide a complete overview of male life history. Implications of recent anthropological data on contemporary health issues such as prostate cancer and the development of a male contraceptive are also discussed. Finally, several theories are presented that may contribute to our understanding of the evolution of male life histories and reproductive ecology, including theoretical suggestions involving the role of competition, mate choosiness, and potential constraints on male insemination ability, as well as a theory suggesting that male reproductive ecology may be best understood by analyzing energetic allocation decisions between differing somatic tissues that may be indicative of the competing needs for optimizing survivorship and reproductive effort. Directions for future research are finally considered.

show abstract

The Effect of Preweaning Undernutrition upon the Sexual Development of Male Mice

Cited by 11 publications

References 14 publications

Impact of bisphenol-A on the spliceosome and meiosis of sperm in the testis of adolescent mice

Impact of bisphenol-A on the spliceosome and meiosis of sperm in the testis of adolescent mice

Serum leptin levels and anthropometric correlates in Ache Amerindians of eastern Paraguay

Reproductive ecology and life history of the human male

Contact Info

Product

Resources

About