The effect of probiotics on functional constipation in adults

Mitelmão, Fabiana Cristina Rosa; Bergamaschi, Cristiane de Cássia; Gerenutti, Marli; Hächel, Karin; Silva, Marcus Tolentino; Balcão, Victor M.; Vila, Marta Maria Duarte Carvalho

doi:10.1097/md.0000000000024938

Cited by 11 publications

(4 citation statements)

References 19 publications

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“…Several studies have shown that probiotics may be effective in treating constipation [8]. In our study, a probiotic mixture, BIO-THREE , including Streptococcus faecalis , Bacillus mesentericus , and Clostridium butyricum , significantly relieved constipation and improved insulin resistance among patients with schizophrenia [9].…”

Section: Probiotics Improved Both Constipation and Insulin Resistance In Schizophrenic Patientsmentioning

confidence: 54%

The Potential of Probiotics in the Treatment of Schizophrenia

Nagamine

2021

CNPT

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Patients with schizophrenia have a higher prevalence of dysbiosis and metabolic disorders. Some probiotics significantly relieve constipation and improve insulin resistance in patients with schizophrenia, with concomitant improvement in psychiatric symptoms. Schizophrenic patients whose psychiatric symptoms are improved by probiotics have characteristics that begin with the three D's: Dysbiosis ; Decreased barrier function in intestinal tract; and Dopamine dysfunction in the prefrontal cortex such as negative symptoms. The effects of probiotics on the central nervous system are nowadays referred to as psychobiotics. However, the underlying mechanism of psychobiotics has not been fully elucidated. In this manuscript, the potential of probiotics in psychiatric practice is discussed based mainly on the author's clinical studies. Modulation of the composition of intestinal microbiota with probiotics may be a new therapeutic target for the treatment of schizophrenia and comorbid insulin resistance.

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Section: Probiotics Improved Both Constipation and Insulin Resistance In Schizophrenic Patientsmentioning

confidence: 54%

The Potential of Probiotics in the Treatment of Schizophrenia

Nagamine

2021

CNPT

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“…Water consumption rates on the day of defecation were also recorded. Faecal transit times were based on the BSS: scores of 1-2 indicate slow transit, 3-5 indicate normal transit, and 6-7 indicate fast transit times (Lewis and Heaton, 1997;Mitelmão et al, 2021).…”

Section: Assessment Of Lower Gi-related Events Using Bowel Habit Diariesmentioning

confidence: 99%

The gastrointestinal status of healthy adults: a post hoc assessment of the impact of three distinct probiotics

Mullish

Michael

Webberley

et al. 2023

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There is a growing awareness that supplementation with probiotic bacteria can impart beneficial effects during gastrointestinal disease, but less is known about the impact of probiotics on healthy subjects. Here, we report the outcomes of a post hoc analysis of recorded daily gastrointestinal events and bowel habits completed by healthy adults participating in a placebo-controlled, single-centre, randomised, double-blind, quadruple-arm probiotic tolerability study. Extensive screening ensured the healthy status of subjects entering the study and during a 2-week pre-intervention run-in period, a burden of gastrointestinal events (stomach pains, indigestion, acid reflux, stomach tightening, nausea and vomiting, stomach rumbling, bloating, belching and flatulence) was identified suggesting GI discomfort within the population. In the subsequent 12-week intervention period with 3 distinct probiotic formulations and a matched-placebo, reductions in the incidence rates of bloating, borborygmus, stomach pains, slow faecal transit and incomplete defecations were observed in the probiotic groups compared to the placebo. These results highlighted differing responses among the probiotic formulations tested and indicated potential anti-constipation effects. Product specific modulations in circulating interleukin-6 levels and in the composition of the gut microbiota were also detected. Together, these data suggest a role for probiotic supplementation to exert beneficial effects on the gastrointestinal functioning of healthy subjects and highlight the need for further longer-term studies in healthy populations to gain a greater understanding of the impact of probiotics.

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“…In medical practice, probiotics are often used to treat functional diseases of the gastrointestinal tract, beneficially altering the gut microbiota and relieving abdominal symptoms, including constipation [ 51 , 52 , 53 ]. Probiotics may improve intestinal transit time, stool consistency, and frequency [ 54 , 55 , 56 ].…”

Section: Discussionmentioning

confidence: 99%

Tryptophan Metabolism in Postmenopausal Women with Functional Constipation

Blonska,

Chojnacki,

Macieja

et al. 2023

IJMS

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Constipation belongs to conditions commonly reported by postmenopausal women, but the mechanism behind this association is not fully known. The aim of the present study was to determine the relationship between some metabolites of tryptophan (TRP) and the occurrence and severity of abdominal symptoms (Rome IV) in postmenopausal women with functional constipation (FC, n = 40) as compared with age-adjusted postmenopausal women without FC. All women controlled their TRP intake in their daily diet. Urinary levels of TRP and its metabolites, 5-hydroxyindoleacetic acid (5-HIAA), kynurenine (KYN), and 3-indoxyl sulfate (indican, 3-IS), were determined by liquid chromatography/tandem mass spectrometry. Dysbiosis was assessed by a hydrogen–methane breath test. Women with FC consumed less TRP and had a lower urinary level of 5-HIAA, but higher levels of KYN and 3-IS compared with controls. The severity of symptoms showed a negative correlation with the 5-HIAA level, and a positive correlation with the 3-IS level. In conclusion, changes in TRP metabolism may contribute to FC in postmenopausal women, and dysbiosis may underlie this contribution.

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The effect of probiotics on functional constipation in adults

Cited by 11 publications

References 19 publications

The Potential of Probiotics in the Treatment of Schizophrenia

The Potential of Probiotics in the Treatment of Schizophrenia

The gastrointestinal status of healthy adults: a post hoc assessment of the impact of three distinct probiotics

Tryptophan Metabolism in Postmenopausal Women with Functional Constipation

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