The effect of probiotics on immunogenicity of spermatozoa in couples suffering from recurrent spontaneous abortion

Rafiee, Mitra; Sereshki, Nasrin; Alipour, Razieh; Ahmadipanah, Vahid; Sarvar, Davod Pashoutan; Wilkinson, David

doi:10.1186/s12865-022-00506-3

Cited by 8 publications

(2 citation statements)

References 36 publications

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“…Studies have also shown that supplementation with Lactobacillus reuteri can improve sperm motility ( Valcarce et al, 2017 ) and increase testosterone levels in aged male mice ( Poutahidis et al, 2014 ). Supplementation with L. casei rhamnosus Döderleini improves sperm immunogenicity and might be helpful for couples suffering from recurrent immunological spontaneous abortion ( Rafiee et al, 2022 ). Oral administration of the three commensal Lactobacillus spp.…”

Section: Discussionmentioning

confidence: 99%

Characterization of the semen, gut, and urine microbiota in patients with different semen abnormalities

et al. 2023

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IntroductionSemen quality is decreasing worldwide, leading to increased male infertility. This study analyzed the microbiota of the gut, semen, and urine in individuals with semen abnormalities to identify potential probiotics and pathogenic bacteria that affect semen parameters and help develop new methods for the diagnosis and treatment of patients with semen abnormalities.MethodsWe recruited 12 individuals with normal semen parameters (control group), 12 with asthenospermia but no semen hyperviscosity (Group_1), 6 with oligospermia (Group_2), 9 with severe oligospermia or azoospermia (Group_3), and 14 with semen hyperviscosity only (Group_4). The semen, gut, and urine microbiota were examined by analyzing the 16S ribosomal RNA gene sequence using next-generation sequencing.ResultsThe gut microbes were clustered into the highest number of operational taxonomic units, followed by urine and semen. Furthermore, the α-diversity of gut microbes was highest and significantly different from that of urine and semen microbiota. The microbiota of the gut, urine, and semen were all significantly different from each other in terms of β-diversity. The gut abundance of Collinsella was significantly reduced in groups 1, 3, and 4. Furthermore, the gut abundance of Bifidobacterium and Blautia was significantly decreased in Group_1, while that of Bacteroides was significantly increased in Group_3. The abundance of Staphylococcus was significantly increased in the semen of groups 1 and 4. Finally, Lactobacillus abundance was significantly reduced in the urine of groups 2 and 4.DiscussionThis study comprehensively describes the differences in intestinal and genitourinary tract microbiota between healthy individuals and those with abnormal semen parameters. Furthermore, our study identified Collinsella, Bifidobacterium, Blautia, and Lactobacillus as potential probiotics. Finally, the study identified Bacteroides in the gut and Staphylococcus in semen as potential pathogenic bacteria. Our study lays the foundation of a new approach to the diagnosis and treatment of male infertility.

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Section: Discussionmentioning

confidence: 99%

Characterization of the semen, gut, and urine microbiota in patients with different semen abnormalities

et al. 2023

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“…Studies have also shown that supplementation with Lactobacillus reuteri can improve sperm motility [58] and increase testosterone levels in aged male mice [74]. Supplementation with L. casei rhamnosus Döderleini improves sperm immunogenicity and might be helpful for couples suffering from recurrent immunological spontaneous abortion [75]. Oral administration of the three commensal Lactobacillus spp.…”

Section: Discussionmentioning

confidence: 99%

Characterization of the semen, gut, and urine microbiota in patients with different semen abnormalities

Cao

Wang

Pan

et al. 2023

Preprint

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Background Semen quality is decreasing worldwide, leading to increased male infertility. This study analyzed the microbiota of the gut, semen, and urine in individuals with semen abnormalities to identify potential probiotics and pathogenic bacteria that affect semen parameters and help develop new methods for the diagnosis and treatment of patients with semen abnormalities. We recruited 12 individuals with normal semen parameters (control group), 12 with asthenospermia but no semen hyperviscosity (Group_1), 6 with oligospermia (Group_2), 9 with severe oligospermia or azoospermia (Group_3), and 14 with semen hyperviscosity only (Group_4). The semen, gut, and urine microbiota were examined by analyzing the 16S ribosomal RNA gene sequence using next-generation sequencing. Results The gut microbes were clustered into the highest number of operational taxonomic units, followed by urine and semen. Furthermore, the α-diversity of gut microbes was highest and significantly different from that of urine and semen microbiota. The microbiota of the gut, urine, and semen were all significantly different from each other in terms of β-diversity. At the genus level, Bifidobacterium, Blautia, Bacteroides, Faecalibacterium, and Prevotella were predominant in the gut; Staphylococcus, Streptococcus, Prevotella, Finegoldia, and Corynebacterium were predominant in urine; and Lactobacillus, Prevotella, Finegoldia, Staphylococcus, Streptococcus, Ureaplasma, and other unidentified bacteria were predominant in semen. β-Diversity of the gut microbiota was significantly different among the control, Group_1, and Group_3. The gut abundance of Collinsella was significantly reduced in groups 1, 3, and 4. Furthermore, the gut abundance of Bifidobacterium and Blautia was significantly decreased in Group_1, while that of Bacteroides was significantly increased in Group_3. The abundance of Staphylococcus was significantly increased in the semen of groups 1 and 4. Finally, Lactobacillus abundance was significantly reduced in the urine of groups 2 and 4. Conclusions This study comprehensively describes the differences in intestinal and genitourinary tract microbiota between healthy individuals and those with abnormal semen parameters. Furthermore, our study identified Collinsella, Bifidobacterium, Blautia, and Lactobacillus as potential probiotics. Finally, the study identified Bacteroides in the gut and Staphylococcus in semen as potential pathogenic bacteria. Our study lays the foundation of a new approach to the diagnosis and treatment of male infertility.

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Role of Synbiotics in Reproductive Disorders

Thapa,

Gilhotra,

Bhat

et al. 2024

Synbiotics in Human Health: Biology to Drug Delivery

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The effect of probiotics on immunogenicity of spermatozoa in couples suffering from recurrent spontaneous abortion

Cited by 8 publications

References 36 publications

Characterization of the semen, gut, and urine microbiota in patients with different semen abnormalities

Characterization of the semen, gut, and urine microbiota in patients with different semen abnormalities

Characterization of the semen, gut, and urine microbiota in patients with different semen abnormalities

Role of Synbiotics in Reproductive Disorders

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