The Effect of Problem Solving Therapy on Breast Cancer Women

Taeidi, Elham; Montazeri, Simmin; Behroozi, Nasser; Zadeh, Mohammad Hosein Haghighy; Deilami, Ahmad Ahmadzadeh

doi:10.5812/ijcm.69336

Cited by 1 publication

(1 citation statement)

References 19 publications

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“…Breast cancer has been classified as first-ranked worrying disease among women around the world [4]. According to statistics, more than one million new cases are annually diagnosed with the disease [5,6].…”

Section: Introductionmentioning

confidence: 99%

Theranostic Effect of Folic Acid Functionalized MIL‐100(Fe) for Delivery of Prodigiosin and Simultaneous Tracking‐Combating Breast Cancer

Mokhtarian

Rastegari

Zeinali

et al. 2022

Journal of Nanomaterials

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The metal organic framework (MOF) member, MIL-100(Fe), is considered as attractive drug nanocarrier that may be due to the great porosity, colloidal stability, and biocompatibility. In the present study, the new electrochemical synthesis procedure was presented for MIL-100(Fe) building block, and secondly, folic acid (FA) was introduced to the structure for assessing its potential targeted ability to be entrapped by folic acid-positive breast cancer cells, MCF-7. Several techniques such as SEM, XRD, and FT-IR were used to characterize synthesized nanostructures. Both MIL-100(Fe) and MIL-100(Fe)/FA nanoparticles were between 50 to 200 nm with a slightly positive net charge with an area of 1350 and 831.84 m2/g, respectively. The prodigiosin (PG) is selected as a model drug for MIL-100(Fe) and MIL-100(Fe)/FA-targeted delivery owing to its natural fluorescence and cancer cell selectiveness. The loading capacity of both nanocarrier was around 40% with 93-97% loading efficacy. Moreover, the pH-sensitive prodigiosin release rate of MIL-100(Fe)@PG and MIL-100(Fe)/FA@PG showed that 69 to 73% of the drug was released after 24 hours in an acidic environment with around 20% unwanted leakage. The anticancer potential MIL-100(Fe)/FA cells showed the improvement of selective index (SI) from 3.21 to 12.48 which means that folic acid acts as an effective ligand. The study of cells treated with fluorescence microscopy and flow cytometry analysis reveals the dependence of the receptor on the nanoparticle through endocytosis. Considering the effects of nanoparticles on healthy cells, MIL-100(Fe) and MIL-100(Fe)/FA nanoparticles can be introduced as targeted drug delivery systems for smart targeting breast cancer cells with minimal side effects.

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Section: Introductionmentioning

confidence: 99%