The effect of processing parameters and solid concentration on the mechanical and microstructural properties of freeze-casted macroporous hydroxyapatite scaffolds

Farhangdoust, Sajad; Zamanian, Ali; Yasaei, Mana; Khorami, Mina

doi:10.1016/j.msec.2012.09.013

Cited by 67 publications

(40 citation statements)

References 52 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Color code: blue: no defects [26–31, 33, 36, 38, 40, 41, 43, 44, 46, 50–55, 61, 64, 65, 67, 68, 70, 71, 73, 77, 78, 85, 90, 91, 94, 98, 100, 103–110, 113, 115, 118, 124–127, 129, 130, 132, 134, 135, 143], yellow: defects [25, 52, 86, 91, 96], white: cannot tell from the published micrographs [37, 39, 49, 56, 91, 95, 96, 119]. …”

Section: Resultsmentioning

confidence: 99%

“…Data from references [26–28, 31, 36–39, 46, 49, 51–53, 56, 61, 64, 65, 67, 68, 70, 71, 73, 77, 78, 85, 94–96, 103–106, 113, 118, 119, 125–127, 129, 130, 132]. …”

Section: Resultsmentioning

confidence: 99%

“…References for the data: water [8, 12, 26, 27, 31, 33–38, 43–49, 51, 52, 55–61, 68, 69, 72–76, 81, 84, 86–92, 94–101, 103, 104, 111, 113, 116, 119, 124, 128–132, 134, 135], camphene [9, 29, 30, 42, 50, 64–67, 70, 80, 85, 93, 102, 105–109, 114, 115, 117, 118, 120–123, 125–127, 136], TBA [10, 32, 39–41, 53, 62, 63, 71, 77, 78, 82, 83, 110, 137]. The marker size is proportional to the pore size.…”

Section: Resultsmentioning

confidence: 99%

“…The papers analyzed cover a variety of materials including ceramics (alumina [8–11, 26, 28, 32, 36, 38, 43, 48, 54, 58, 77, 81, 89, 102, 104, 105, 111, 112, 131, 143], zirconia [49, 80, 100, 101, 103, 125–127], silicon carbide [45, 106, 130], silicon nitride [35, 69, 72, 75, 76, 79, 84, 87, 88, 128], mullite [90, 110, 124, 137], hydroxyapatite [12, 37, 44, 52, 61, 68, 78, 86, 91, 95–98, 107, 109, 113, 115, 120, 134, 135], tri-calcium phosphate [31, 40, 56, 117, 118], lead zirconate titanate (PZT) [39, 63, 74, 82, 83, 121, 122], barium titanate [73], silica/kaolinite [47], titania [24, 29, 50, 99], zirconium diboride [51], chromium carbide [42], sialon [64, 66], lithium iron phosphate [60], yttrium orthosilicate [57, 62], cermets [116, …”

Section: Methodsmentioning

confidence: 99%

See 3 more Smart Citations

A meta-analysis of the mechanical properties of ice-templated ceramics and metals

Deville

Meille

Seuba

2015

Science and Technology of Advanced Materials

View full text Add to dashboard Cite

Ice templating, also known as freeze casting, is a popular shaping route for macroporous materials. Over the past 15 years, it has been widely applied to various classes of materials, and in particular ceramics. Many formulation and process parameters, often interdependent, affect the outcome. It is thus difficult to understand the various relationships between these parameters from isolated studies where only a few of these parameters have been investigated. We report here the results of a meta analysis of the structural and mechanical properties of ice templated materials from an exhaustive collection of records. We use these results to identify which parameters are the most critical to control the structure and properties, and to derive guidelines for optimizing the mechanical response of ice templated materials. We hope these results will be a helpful guide to anyone interested in such materials.

show abstract

Section: Resultsmentioning

confidence: 99%

“…Data from references [26–28, 31, 36–39, 46, 49, 51–53, 56, 61, 64, 65, 67, 68, 70, 71, 73, 77, 78, 85, 94–96, 103–106, 113, 118, 119, 125–127, 129, 130, 132]. …”

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

See 2 more Smart Citations

A meta-analysis of the mechanical properties of ice-templated ceramics and metals

Deville

Meille

Seuba

2015

Science and Technology of Advanced Materials

View full text Add to dashboard Cite

show abstract

“…It has also been developed to tailor the pore structure of porous materials by manipulating the degree of porosity, pore size, pore shape, and pore orientation[22,23]. This method have shown many benefits, such as the adaptability of the process as well as providing high strength and a variety of pore sizes, and environmental friendliness[24].…”

Section: Introductionmentioning

confidence: 99%

Fabrication of Chitosan Silk-based Tracheal Scaffold Using Freeze-Casting Method

Nematollahi

Tafazzoli-Shadpour

Zamanian

et al. 2017

IBJ

View full text Add to dashboard Cite

Background:Since the treatments of long tracheal lesions are associated with some limitations, tissue engineered trachea is considered as an alternative option. This study aimed at preparing a composite scaffold, based on natural and synthetic materials for tracheal tissue engineering.Methods:Nine chitosan silk-based scaffolds were fabricated using three freezing rates (0.5, 1, and 2°C/min) and glutaraldehyde (GA) concentrations (0, 0.4, and 0.8 wt%). Samples were characterized, and scaffolds having mechanical properties compatible with those of human trachea and proper biodegradability were selected for chondrocyte cell seeding and subsequent biological assessments.Results:The pore sizes were highly influenced by the freezing rate and varied from 135.3×372.1 to 37.8×83.4 µm. Swelling and biodegradability behaviors were more affected by GA rather than freezing rate. Tensile strength raised from 120 kPa to 350 kPa by an increment of freezing rate and GA concentration. In addition, marked stiffening was demonstrated by increasing elastic modulus from 1.5 MPa to 12.2 MPa. Samples having 1 and 2°C/min of freezing rate and 0.8 wt% GA concentration made a non-toxic, porous structure with tensile strength and elastic modulus in the range of human trachea, facilitating the chondrocyte proliferation. The results of 21-day cell culture indicated that glycosaminoglycans content was significantly higher for the rate of 2°C/min (12.04 µg/min) rather than the other (9.6 µg/min).Conclusion:A homogenous porous structure was created by freeze drying. This allows the fabrication of a chitosan silk scaffold cross-linked by GA for cartilage tissue regeneration with application in tracheal regeneration.

show abstract

Porous Bioceramics Produced by Impregnation of 3D‐Printed Wax Mold: Ceramic Architectural Control and Process Limitations

et al. 2016

View full text Add to dashboard Cite

Current architectural and production limitations prevent the manufacturing standardization and design of bioceramics. Such limitations have hindered advances in bone tissue engineering and regeneration. In this context, we propose a bioceramic manufacturing process based on the impregnation of wax molds produced by additive manufacturing. Hydroxyapatite bioceramics with custom architectures were fabricated to evaluate the reliability, robustness, and limitations of this process. Results indicate that this process preserves phase biocompatibility, permits homogeneous shrinkage of the biomaterial during heat treatment, and allows reproducible and precise manufacturing of custom architectures.

show abstract

The effect of processing parameters and solid concentration on the mechanical and microstructural properties of freeze-casted macroporous hydroxyapatite scaffolds

Cited by 67 publications

References 52 publications

A meta-analysis of the mechanical properties of ice-templated ceramics and metals

A meta-analysis of the mechanical properties of ice-templated ceramics and metals

Fabrication of Chitosan Silk-based Tracheal Scaffold Using Freeze-Casting Method

Porous Bioceramics Produced by Impregnation of 3D‐Printed Wax Mold: Ceramic Architectural Control and Process Limitations

Contact Info

Product

Resources

About