The effect of progesterone and 17-β estradiol on membrane-bound HLA-G in adipose derived stem cells

Moslehi, Akram; Hashemibeni, Batool; Moslehi, Azam; Akbari, Maryam Ali; Adib, Minoo

doi:10.4196/kjpp.2016.20.4.341

Cited by 3 publications

(2 citation statements)

References 28 publications

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“…During early phases of pregnancy, both hormones are elevated. Experimental studies failed to demonstrate a beneficial effect of estradiol toward the expression of HLA-G in adipose-derived stem cells, and may even be interpreted as an antagonist effect of estradiol compared with progesterone, which would tend to be confirmed by the present work (17).…”

Section: Discussionsupporting

confidence: 66%

Influence of hormones on the immunotolerogenic molecule HLA-G: a cross-sectional study in patients with congenital adrenal hyperplasia

Nguyen

Rouas‐Freiss

Funck‐Brentano

et al. 2019

European Journal of Endocrinology

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Background HLA-G is an immune checkpoint molecule, naturally expressed during pregnancy, playing a critical role in the tolerance of the fetal semi-allograft from the maternal immune system. While HLA-G expression levels are associated with progesterone, the influence of other hormones is still unclear. Congenital adrenal hyperplasia (CAH) represents an adequate model to study the hormonal influence on biomarkers as it leads to impaired cortisol biosynthesis and increased progesterone and androgens production due to 21-hydroxylase enzyme deficiency. Methods In a cross-sectional study of CAH patients matched on sex and age with healthy control, the association between circulating levels of soluble HLA-G and hormones was assessed by use of non-parametric analyses tests. Multivariable linear regressions were performed on normalized data. Results Overall, 83 CAH patients and 69 healthy controls were included. Among CAH patients, all were under glucocorticoid and 52 (62.6%) were under mineralocorticoid supplementation. Compared to controls, CAH patients had increased HLA-G levels (15 vs 8 ng/mL, P = 0.02). In controls, HLA-G level was independently associated with progesterone and estradiol (β = 0.44 (0.35–1.27) and −0.44 (−0.94, −0.26) respectively, both P values = 0.001). In CAH patients, HLA-G level was independently associated with mineralocorticoid supplementation dosage (β = 0.25 (0.04–0.41), P = 0.001) and estradiol (β = −0.22 (−0.57, −0.02), P < 0.001). Conclusion CAH patients had higher HLA-G levels than healthy controls. HLA-G level was positively associated with progesterone and corticosteroid supplementation, and negatively with estradiol. The association between mineralocorticoid, renin and HLA-G levels may suggest a role of the renin-angiotensin system in the expression of soluble HLA-G.

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Section: Discussionsupporting

confidence: 66%

Influence of hormones on the immunotolerogenic molecule HLA-G: a cross-sectional study in patients with congenital adrenal hyperplasia

Nguyen

Rouas‐Freiss

Funck‐Brentano

et al. 2019

European Journal of Endocrinology

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“…Progesterone is also shown to influence the immune modulatory effects of MSCs by enhancing the expression and secretion of immunomodulatory proteins such as HLA-G (human leucocyte antigen G), PIBF (progesterone immunomodulatory-binding factor 1), PGE2 (prostaglandin E2) and IL-6 (interleukin 6) in MSC of adipose (Ref. 45), bone marrow and endometrial origin (Ref. 46).…”

Section: Oestrogen and Progesterone Influence On Stem Cellsmentioning

confidence: 99%

Oestrogen, progesterone and stem cells: the discordant trio in endometriosis?

Susheelamma

Pillai

Nair

2018

Expert Rev. Mol. Med.

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Oestrogen-progesterone signalling is highly versatile and critical for the maintenance of healthy endometrium in humans. The genomic and nongenomic signalling cascades initiated by these hormones in differentiated cells of endometrium have been the primary focus of research since 1920s. However, last decade of research has shown a significant role of stem cells in the maintenance of a healthy endometrium and the modulatory effects of hormones on these cells. Endometriosis, the growth of endometrium outside the uterus, is very common in infertile patients and the elusiveness in understanding of disease pathology causes hindrance in selection of treatment approaches to enhance fertility. In endometriosis, the stem cells are dysfunctional as it can confer progesterone resistance to their progenies resulting in disharmony of hormonal orchestration of endometrial homeostasis. The bidirectional communication between stem cell signalling pathways and oestrogen-progesterone signalling is found to be disrupted in endometriosis though it is not clear which precedes the other. In this paper, we review the intricate connection between hormones, stem cells and the cross-talks in their signalling cascades in normal endometrium and discuss how this is deregulated in endometriosis. Re-examination of the oestrogen-progesterone dependency of endometrium with a focus on stem cells is imperative to delineate infertility associated with endometriosis and thereby aid in designing better treatment modalities.

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HLA-G and Recurrent Pregnancy Loss

Barbaro

Inversetti

Cristodoro

et al. 2023

IJMS

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Placentation is an immunological compromise where maternal immune system cells and trophoblastic cells interact to reach an equilibrium condition. Although the cross talk between the two systems is complex and not completely understood, Human Leukocyte Antigen G (HLA-G), expressed on trophoblastic cell surfaces, seems to be one of the main molecules involved in the modulation of both local and systemic maternal immune response. The prevalence of recurrent pregnancy loss (RPL), probably underestimated, is 5% of all women who achieve pregnancy, and about 40–60% percent of RPL cases are unexplained. There is an immunological analogy between allograft rejection and miscarriage, and the purpose of this review is to describe how the HLA-G pathway alterations are involved in disrupting the immunologic balance and in increasing the risk of recurrent pregnancy loss.

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The effect of progesterone and 17-β estradiol on membrane-bound HLA-G in adipose derived stem cells

Cited by 3 publications

References 28 publications

Influence of hormones on the immunotolerogenic molecule HLA-G: a cross-sectional study in patients with congenital adrenal hyperplasia

Influence of hormones on the immunotolerogenic molecule HLA-G: a cross-sectional study in patients with congenital adrenal hyperplasia

Oestrogen, progesterone and stem cells: the discordant trio in endometriosis?

HLA-G and Recurrent Pregnancy Loss

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