The effect of progesterone on oxytocin-induced contraction of the three separate layers of human gestational myometrium in the uterine body and lower segment

Pinto, Roberto Martin; Lerner, U; Pontelli, H

doi:10.1016/0002-9378(67)90109-3

Cited by 20 publications

(9 citation statements)

References 10 publications

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“…There is evidence that estrogen is an inducer of human uterine contractions that are attenuated by P 4 (ref. 13). Because estrogen receptor α (ER-α) expression in the human myometrium is upregulated during labor 9 , ‘functional estrogen activation’ in parallel with functional P 4 withdrawal may be involved in human parturition.…”

mentioning

confidence: 99%

Revisiting Reproduction: Prematurity and the puzzle of progesterone resistance

Hirota

Cha

Dey

2010

Nat Med

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confidence: 99%

Revisiting Reproduction: Prematurity and the puzzle of progesterone resistance

Hirota

Cha

Dey

2010

Nat Med

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“…PHARRISS & RUSSELL (1968) showed that 20 pg progesterone per ml dissolved in 3 yo ethanol or 0.06 yo albumin carrier could inhibit spontaneous contractions in an organ bath. PINTO et al (1967) showed that 500 to 2500 klg progesterone per ml in an organ bath blocked the action of oxytocin on the internal and medial layer of the myometrium, while in the external layer it reduced the intensity but increased the frequency of the contractions. In contrast to our results they stated that the progesterone block was not reversible.…”

Section: Discussionmentioning

confidence: 99%

Acute in Vitro Effect of Progesterone Dissolved in Dimethyl Sulphoxide on Isotonic Contractions and Electrical Potentials of Isolated Uteri from Early Pregnant or Hormone Pre‐Treated Rats

Einer‐Jensen¹

1971

Acta Pharmacologica et Toxicologica

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Spontaneous isotonic contractions and electrical activity were obtained from 3 cm sections of rat uteri placed in a 6 ml organ bath. The electrical activity was recorded by means of 2 pairs of platinum wire electrodes, each pair measuring the activity over a 2 to 4 mm uterus section. Uteri were used from 21 pregnant rats (length of pregnancy was 1 to 8 days) and from 4 non-pregnant rats pre-treated for 6 or 8 days with 10 mg/kg progesterone subcutaneously. When 0.17 vol % dimethyl sulphoxide (DMSO) was added to the organ bath no or only small changes in the electrical activity and the spontaneous contractions of the myometrium were observed. Administration of progesterone (83 pg per ml organ bath) dissolved in DMSO (50 mglml) inhibited the contractions after 10 to 60 seconds, but no or only minor changes were registered in the electrical activity. After DMSO-progesterone solution had been washed out, the contractions reappeared after 7 to 20 minutes.

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“…Second, complex hormonal changes occur during pregnancy. The pregnant myometrium is quiescent mainly due to increased progesterone [9] until the beginning of highly organized contractions at labor [10]. Additionally, the increase in estrogen from mid-gestation to birth is to myometrial contractility [11].…”

Section: Introductionmentioning

confidence: 99%

Mechanism of Relaxation Via TASK-2 Channels in Uterine Circular Muscle of Mouse

Hong

Sung

Kim

et al. 2013

Korean J Physiol Pharmacol

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Plasma pH can be altered during pregnancy and at labor. Membrane excitability of smooth muscle including uterine muscle is suppressed by the activation of K+ channels. Because contractility of uterine muscle is regulated by extracellular pH and humoral factors, K+ conductance could be connected to factors regulating uterine contractility during pregnancy. Here, we showed that TASK-2 inhibitors such as quinidine, lidocaine, and extracellular acidosis produced contraction in uterine circular muscle of mouse. Furthermore, contractility was significantly increased in pregnant uterine circular muscle than that of non-pregnant muscle. These patterns were not changed even in the presence of tetraetylammonium (TEA) and 4-aminopyridine (4-AP). Finally, TASK-2 inhibitors induced strong myometrial contraction even in the presence of L-methionine, a known inhibitor of stretchactivated channels in myometrium. When compared to non-pregnant myometrium, pregnant myometrium showed increased immunohistochemical expression of TASK-2. Therefore, TASK-2, seems to play a key role during regulation of myometrial contractility in the pregnancy and provides new insight into preventing preterm delivery.

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The effect of progesterone on oxytocin-induced contraction of the three separate layers of human gestational myometrium in the uterine body and lower segment

Cited by 20 publications

References 10 publications

Revisiting Reproduction: Prematurity and the puzzle of progesterone resistance

Revisiting Reproduction: Prematurity and the puzzle of progesterone resistance

Acute in Vitro Effect of Progesterone Dissolved in Dimethyl Sulphoxide on Isotonic Contractions and Electrical Potentials of Isolated Uteri from Early Pregnant or Hormone Pre‐Treated Rats

Mechanism of Relaxation Via TASK-2 Channels in Uterine Circular Muscle of Mouse

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