The effect of progesterone on the activity-wheel running of ovariectomized rats

Rodier, William I.; Segal, Steward

doi:10.1016/0018-506x(77)90057-5

Cited by 15 publications

(5 citation statements)

References 8 publications

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“…1 (treated with EB only) had a higher number of chamber midline crossings than animals in Exp. 2 (treated with a lower dose of EB and P), these findings are consistent with previous studies revealing that estradiol increases (Rodier and Segal, 1977), and progesterone decreases (Axelson et al, 1981), locomotor activity. Taken together, these findings suggest that SRC-1 and CBP are important for the expression of PRdependent proceptivity.…”

Section: Exp 2: Pr-dependent Proceptive Behaviorsupporting

confidence: 91%

Nuclear receptor coactivators function in estrogen receptor- and progestin receptor-dependent aspects of sexual behavior in female rats

Molenda-Figueira

Williams

Griffin

et al. 2006

Hormones and Behavior

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The ovarian hormones, estradiol (E) and progesterone (P) facilitate the expression of sexual behavior in female rats. E and P mediate many of these behavioral effects by binding to their respective intracellular receptors in specific brain regions. Nuclear receptor coactivators, including Steroid Receptor Coactivator-1 (SRC-1) and CREB Binding Protein (CBP), dramatically enhance ligand-dependent steroid receptor transcriptional activity in vitro. Previously, our lab has shown that SRC-1 and CBP modulate estrogen receptor (ER)-mediated induction of progestin receptor (PR) gene expression in the ventromedial nucleus of the hypothalamus (VMN) and hormone-dependent sexual receptivity in female rats. Female sexual behaviors can be activated by high doses of E alone in ovariectomized rats, and thus are believed to be ER-dependent. However, the full repertoire of female sexual behavior, in particular, proceptive behaviors such as hopping, darting and ear wiggling, are considered to be PR-dependent. In the present experiments, the function of SRC-1 and CBP in distinct ER- (Exp. 1) and PR- (Exp. 2) dependent aspects of female sexual behavior was investigated. In Exp. 1, infusion of antisense oligodeoxynucleotides to SRC-1 and CBP mRNA into the VMN decreased lordosis intensity in rats treated with E alone, suggesting that these coactivators modulate ER-mediated female sexual behavior. In Exp. 2, antisense to SRC-1 and CBP mRNA around the time of P administration reduced PR-dependent ear wiggling and hopping and darting. Taken together, these data suggest that SRC-1 and CBP modulate ER and PR action in brain and influence distinct aspects of hormone-dependent sexual behaviors. These findings support our previous studies and provide further evidence that SRC-1 and CBP function together to regulate ovarian hormone action in behaviorally-relevant brain regions.

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Section: Exp 2: Pr-dependent Proceptive Behaviorsupporting

confidence: 91%

Nuclear receptor coactivators function in estrogen receptor- and progestin receptor-dependent aspects of sexual behavior in female rats

Molenda-Figueira

Williams

Griffin

et al. 2006

Hormones and Behavior

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“…Given that P4 interacts with estrogen in several ways to affect signaling, disease state and behavior, including wheel running (Baudry, Bi, & Aguirre, 2013; Rodier III & Segal, 1977), it is important that future studies investigate the role of P4 in BDNF induction by exercise.…”

Section: Discussionmentioning

confidence: 99%

Exogenous progesterone exacerbates running response of adolescent female mice to repeated food restriction stress by changing α4-GABAA receptor activity of hippocampal pyramidal cells

et al. 2015

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Adolescent females are particularly vulnerable to mental illnesses with comorbidity of anxiety, such as anorexia nervosa (AN). We used an animal model of AN, called activity-based anorexia (ABA), to investigate the neurobiological basis of vulnerability to repeated, food restriction (FR) stress-evoked anxiety. Twenty-one of 23 adolescent female mice responded to the 1st FR with increased wheel running activity (WRA), even during the limited period of food access, thereby capturing AN's symptoms of voluntary FR and over-exercise. Baseline WRA was an excellent predictor of FR-elicited WRA (severity of ABA, SOA), with high baseline-runners responding to FR with minimal SOA (i.e., negative correlation). Nine gained resistance to ABA following the 1st FR. Even though allopregnanolone (3α-OH-5α-pregnan-20-one, THP), the metabolite of progesterone (P4), is a well-recognized anxiolytic agent, subcutaneous P4 to these ABA-resistant animals during the 2nd FR was exacerbative, evoking greater WRA than the counterpart resistant group that received oil vehicle, only. Moreover, P4 had no WRA-reducing effect on animals that remained ABA-vulnerable. To explain the sensitizing effect of P4 upon the resistant mice, we examined the relationship between P4 treatment and levels of the α4 subunit of GABAARs at spines of pyramidal cells of the hippocampal CA1, a parameter previously shown to correlate with resistance to ABA. α4 levels at spine membrane correlated strongly and negatively with SOA during the 1st ABA (prior to P4 injection), confirming previous findings. α4 expression levels were greater among P4-treated animals that had gained resistance than of vehicle-treated resistant animals or of the vulnerable animals with or without P4. We propose that α4-GABAARs play a protective role by counterbalancing the ABA-induced increase in excitability of CA1 pyramidal neurons, and although exogenous P4's metabolite, THP, enhances α4 expression, especially among those that can gain resistance, it also interferes with α4-GABAARs’ protective role by desensitizing α4-GABAARs.

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“…Increases in activity are associated with testosterone as well as oestradiol, which also has anorectic effects; ovariectomy results in increased body weight, decreased activity, and increased energy intake (118–121). The ability of oestradiol to increase activity is counteracted by progesterone (122). Activity, food intake, and body weight also vary with the oestrous cycle, with activity peaking at times when circulating oestradiol levels are highest and food intake and body weight are lowest (123, 124).…”

Section: Sensorsmentioning

confidence: 99%

Central Neural and Endocrine Mechanisms of Non‐Exercise Activity Thermogenesis and Their Potential Impact on Obesity

Novak

Levine

2007

J Neuroendocrinology

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Obesity is an ever-increasing problem now that more than one billion people worldwide are overweight or obese (1). More than one-half of Americans are overweight, and the proportion of the population that is overweight, obese, or extremely obese continues to grow (2, 3). Developing nations are quickly catching up with more developed countries with respect to rates of obesity and related health problems (4). This trend cuts across ethnicity, age, gender, and education level (5, 6). Childhood obesity, which portends adult obesity and predicts health problems in adulthood (7), continues to increase (8). Obesity is associated with a slew of deleterious health effects and health-related risk factors, including diabetes, cardiovascular disease, high cholesterol, asthma, arthritis, sleep apnoea, and cancer (6, 9-13), and is also linked with decreased life span (14), disability (15), and a lower in quality of life (16).Weight gain results when energy expenditure is inappropriately low for the caloric intake of an individual. The role of dietary intake and its underlying mechanisms have been the principal focus when examining the rise in obesity (17, 18). Obesity incidence has risen, however, even as dietary quality has improved or energy intake has been reduced (17,18). This circumstance necessitates a critical examination of the other side of the energy balance equation, namely energy expenditure. As illustrated in Fig. 1, total daily energy expenditure (TDEE) consists of basal metabolic rate (BMR), the thermic effect of food, and the energy expenditure of activity. Some studies find a decreased BMR in those predisposed to become obese (19)(20)(21). Even in these obesity-prone individuals, however, the decrease in BMR could not fully explain the positive energy balance incurred (19), and the energy expenditure of physical activity was directly implicated in the development of obesity (20). Smaller, tightly controlled studies lend little support to the belief that differences in resting energy expenditure contribute to the tendency of an individual to gain weight (22, 23). Next, the thermic effect of food contributes little to TDEE in terms of both absolute kcal ⁄ day and variability. This suggests that the remaining component of TDEE is likely to change with obesity and the propensity to gain weight, specifically the energy expenditure of activity. At the population level, sedentary behaviour has increased steadily as physical activity has decreased, and this corresponds to increased obesity and decreased health in both children and adults (22,(24)(25)(26)(27)(28). The current trend in the general population is opposed to communities with heavy physical activity demands, which show very low rates of obesity (29). Indeed, increasing physical activity levels may be the missing link needed to reverse the current obesity trends (18,22,24,25,27,30). The rise in obesity is associated with a decline in the amount of physical activity in which people engage. The energy expended through everyday non-exercise activity, called no...

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The effect of progesterone on the activity-wheel running of ovariectomized rats

Cited by 15 publications

References 8 publications

Nuclear receptor coactivators function in estrogen receptor- and progestin receptor-dependent aspects of sexual behavior in female rats

Nuclear receptor coactivators function in estrogen receptor- and progestin receptor-dependent aspects of sexual behavior in female rats

Exogenous progesterone exacerbates running response of adolescent female mice to repeated food restriction stress by changing α4-GABAA receptor activity of hippocampal pyramidal cells

Central Neural and Endocrine Mechanisms of Non‐Exercise Activity Thermogenesis and Their Potential Impact on Obesity

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