The effect of progesterone on the growth and virulence of listeria monocytogenes

Basher, H.A.; Fowler, David; Seaman, A.; Woodbine, M.

doi:10.1016/s0176-6724(85)80037-7

Cited by 3 publications

(2 citation statements)

References 8 publications

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“…Numerous studies have examined the influence of sex hormones on the pathogenesis of infectious diseases [28]. However, most studies investigated interaction between these hormones and the immune system, and only several studies investigated direct effect of progesterone and other sex hormones on the growth of bacteria [29][30][31]. It has been found that progesterone exhibits a concentration-dependent inhibitory (bacteriostatic) effect on bacterial growth.…”

Section: Discussionmentioning

confidence: 99%

Antimicrobial Activity of Human Follicular Fluids

Stepanović

Djukić

Veljković³

et al. 2003

Gynecol Obstet Invest

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The aim of this study was to explore the antimicrobial activity of human follicular fluid (HFF), to test the hypothesis that different strains of the same bacterial species could display different patterns of susceptibility to antimicrobial action of HFF, and to preliminarily investigate the possible mechanism of antimicrobial action of this fluid. Antimicrobial activity of 60 samples of HFF toward 30 Streptococcus agalactiae strains was determined by the agar diffusion method and broth dilution method. To explore the mechanism of antimicrobial activity, biochemical analyses were performed with selected fluid samples. The obtained results indicate that 38.3% fluid samples did not inhibit bacterial growth, 53.3% showed moderate and 8.3% high antimicrobial activity. The tested effect of HFF on S. agalactiae strains was bactericidal and was not strain dependent. Lysozyme activity was detected in HFF exhibiting antimicrobial activity. There were no statistically significant differences in concentrations of estradiol, progesterone, transferrin, iron, total protein and albumin levels among tested samples regardless of the different rate of antimicrobial activity. The obtained results indicate that lysozyme is most probably a crucial antibacterial agent in this fluid; however, some other still unidentified factors may contribute to it.

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Section: Discussionmentioning

confidence: 99%

Antimicrobial Activity of Human Follicular Fluids

Stepanović

Djukić

Veljković³

et al. 2003

Gynecol Obstet Invest

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“…It was hypothesized that the action of estrogen on fungus may be responsible for the distinct resistance of females (14). Sever;l authors report about inhibitory effects of progesterone on the growth and virulence of various bacteria, fungus and parasites (4,5,8,9,15,19). However, the action of progesterone on virus replication seems to be rarely investigated.…”

Section: Introductionmentioning

confidence: 99%

Influence of Progesterone on Orthopox Viruses in vitro and in vivo

Pfahler¹,

Reimann²,

Muñz³

1987

Journal of Veterinary Medicine, Series B

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Summary The influence of progesterone on virus‐host‐interactions was investigated for orthopox viruses in vitro and in vivo. Virus induced cytopathogenic effects in Vero cells were markedly reduced in presence of the hormone. Dose dependent restriction of viral replication was evaluated by infectivity titration and immunological antigen determination. Progesterone concentrations of 5μg/ml tissue culture medium depressed the production of new viral particles nearly totally. The results obtained by the two different methods indicate that probably later stages of viral synthesis are affected when lower dosages of progesterone are used. The protective activity of progesterone against pathogenic actions of orthopox viruses in vivo was confirmed by using rabbits for intradermal infections. Zusammenfassung Es wurde der Einfluß von Progesteron auf die Virus‐Wirt‐Wechselbeziehung am Beispiel der Orthopocken‐Viren in vitro und in vivo untersucht. Die virusinduzierten zytopathogenen Effekte in Vero‐Zellkulturen wurden in Gegenwart des Hormons deutlich reduziert. Die Hemmung der Virus‐Replikation in Abhängigkeit von der Dosis wurde mittels Infektionstitration sowie immunologischer Antigenbestimmung gemessen. Eine Progesteron‐Konzentration von 5 μg/ml Zellkulturmedium unterdrückte die Bildung von Viruspartikeln nahezu vollständig. Die Ergebnisse der beiden unterschiedlichen Methoden lassen vermuten, daß durch niedrigere Progesteron‐Konzentrationen spätere Stadien der Virussynthese gehemmt werden. Durch intradermale Infektion von Kaninchen konnte die protektive Wirkung von Progesteron gegen zytopathogene Mechanismen der Orthopox‐Viren in vivo bestätigt werden.

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A CD-1 mouse model of infection with <i>Staphylococcus aureus</i>: Influence of gender on infection with MRSA and MSSA isolates

Yanke

Olson

Davies³

et al. 2000

Rev. can. microbiol.

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Staphylococcus aureus is an important pathogen of humans and other animals, causing bacteremia, abscessation, toxemia, and other infectious diseases. An animal model using CD-1 mice was developed to study the pathogenesis of methicillin-resistant Staphylococcus aureus (MRSA) and methicillin-sensitive Staphylococcus aureus (MSSA). When inoculated into the CD-1 mouse model, it was shown that both MSSA isolates, (HR 78 and CSA-1) and MRSA isolates (MRSA 456 and MRSA 457) led to chronic infection of the kidney. Female CD-1 mice inoculated with MRSA 456 proved to be more susceptible to infection and mortality than their male counterparts. Castrated mice became more susceptible to infection than intact male mice, suggesting a hormonal involvement in the infection process.

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The effect of progesterone on the growth and virulence of listeria monocytogenes

Cited by 3 publications

References 8 publications

Antimicrobial Activity of Human Follicular Fluids

Antimicrobial Activity of Human Follicular Fluids

Influence of Progesterone on Orthopox Viruses in vitro and in vivo

A CD-1 mouse model of infection with <i>Staphylococcus aureus</i>: Influence of gender on infection with MRSA and MSSA isolates

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