The effect of progesterone supplementation on pregnancy rates in controlled ovarian stimulation and intrauterine insemination cycles: a randomized prospective trial

Efficacy of luteal phase support with vaginal progesterone in intrauterine insemination: a systematic review and meta-analysis

“…During the second phase of the inclusion process, out of the 11 trials, 1 was excluded because of nonrandomized comparisons [18] and 5 because they did not evaluate the intervention nor the outcomes of interest. Finally, 5 RCT met the inclusion criteria and were included [19][20][21][22][23]. The flow chart of the included in the meta-analysis is shown in Fig.…”

“…Two trials considered for inclusion only one cycle per woman randomized [19,21]. Meanwhile, in the remaining three trials [20,22,23], several cycles per patient were analyzed, as shown in Table 2.…”

“…With regard to the ovarian stimulation protocol, there are also notable differences across the five studies. Maher et al [20] and Erdem et al [23] used 75 IU recombinant follicle stimulating hormone (rFSH), while Ebrahimi et al [22], Kyrou et al [21] and Agha-Hosseini et al [19] used 50 mg of clomiphene citrate (CC) in different regimens. This later trial also administered 5 mg of letrozole daily in one of their study groups.…”

“…Four trials performed randomization through computer-generated sequences [19][20][21]23], except for Ebrahimi et al, who performed sequential allocation [22].…”

“…The five studies provided data for the outcome of clinical pregnancy, achieving a total of 169 events out of 951 cycles in the progesterone group, and 116 events out of 935 cycles in the control group [19][20][21][22][23].…”