1997
DOI: 10.1002/(sici)1098-2388(199711/12)13:6<454::aid-ssu10>3.0.co;2-t
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The effect of prognostic factors on therapeutic outcome following transperineal prostate brachytherapy

Abstract: The objectives of this study were to examine the effect of both disease and treatment related prognostic factors on biochemical control and post‐treatment biopsy. Two‐hundred fifty‐eight patients underwent interactive ultrasound guided transperineal prostate implantation for T1‐T2 prostate cancer using Iodine‐125 (139 patients) and Palladium‐103 (119 patients) and were followed from 6‐67 months (median, 19). Hormonal therapy with 3 months of leuprolide and flutamide prior to implantation and two months given a… Show more

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Cited by 55 publications
(14 citation statements)
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“…Early results reported excellent efficacy based on outcome measures of PSA control. 4,21,[26][27][28][29][30][31][32][33] It has been advocated that brachytherapy techniques represent the optimal method for conformal radiation therapy treatment delivery, based on the high irradiation doses that can be delivered directly to the prostate with a rapid fall-off in exposure to surrounding nontarget tissues. Conformal dose delivery represents the greatest strength of brachytherapy, but it is also the greatest limitation, as any disease that may extend outside of the implant volume will not receive effective irradiation.…”
Section: Ebrt With Brachytherapymentioning
confidence: 99%
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“…Early results reported excellent efficacy based on outcome measures of PSA control. 4,21,[26][27][28][29][30][31][32][33] It has been advocated that brachytherapy techniques represent the optimal method for conformal radiation therapy treatment delivery, based on the high irradiation doses that can be delivered directly to the prostate with a rapid fall-off in exposure to surrounding nontarget tissues. Conformal dose delivery represents the greatest strength of brachytherapy, but it is also the greatest limitation, as any disease that may extend outside of the implant volume will not receive effective irradiation.…”
Section: Ebrt With Brachytherapymentioning
confidence: 99%
“…21,27,28 The currently available data for the modern era of prostate brachytherapy are represented by single-institution retrospective reviews that report their results in terms of PSA control outcomes (Table 2). 4,[28][29][30][31][32][33] Unfortunately, most results are presented in terms of institutionspecific criteria for PSA control. Even so, based on knowledge of pretreatment PSA levels, Gleason score, and T stage, most series have achieved effective stratification of patient groups to provide data by which selection of the optimal therapy according to defined prognostic variables can be based.…”
Section: Ebrt With Brachytherapymentioning
confidence: 99%
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“…8 Implantation was accomplished using a real-time ultrasound guided transperineal technique, which has been described previously. 2,3 The isotope 125 I (Nycomed Amersham, Buckinghamshire, UK) was used in 186 patients and 103 Pd (Theragenics, Norcross, GA) in 82 patients. The general indication for the use of 125 I was a Gleason score Յ 6.…”
Section: Methodsmentioning
confidence: 97%
“…Issues such as patient selection have focused on the use of prostate specific antigen (PSA), Gleason score, and classification to help optimize treatment strategies. [1][2][3] The relation between implant dose, PSA response, and morbidity has been analyzed in hopes of defining brachytherapy dose goals. 4 -6 One method of assessing treatment response, which has been used for both brachytherapy and external beam irradiation, is posttreatment prostate biopsy.…”
mentioning
confidence: 99%