The Effect of Propofol on Human Gastric and Colonic Muscle Contractions

Lee, Tat-Leang; Ang, Sophia Bee Leng; Dambisya, Yoswa M.; Adaikan, Ganesh; Lau, Lang Chu

doi:10.1213/00000539-199911000-00031

Cited by 50 publications

(21 citation statements)

References 11 publications

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“…Antral hypomotility and abnormal duodenal activity have been observed in patients who are receiving morphine and continuous gastric feeding 19 . Propofol, used for sedation, inhibits spontaneous contractile activity and acetylcholine‐mediated contractions of gastric and colonic smooth muscles 20 . The exact mechanism of propofol responsible for impaired gut contractility is unknown.…”

Section: Normal Gi Motilitymentioning

confidence: 99%

Altered GI Motility in Critically Ill Patients

Ukleja

2010

Nut in Clin Prac

107

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Gastrointestinal (GI) motility disturbances are common in critically ill patients. GI tract dysmotility has been linked to increased permeability of intestinal mucosa and bacterial translocation, contributing to systemic inflammatory response syndrome, sepsis, and multiple organ dysfunction syndrome. A key issue in providing nutrition to critically ill patients is intolerance of enteral feeding as a result of impaired GI motility. Remarkable progress has been made in the understanding of the regulation of GI motility in critical illness. Predominant motility abnormalities seen in ICU patients include antral hypomotility, delayed gastric emptying, and reduced migrating motor complexes. The diagnosis of motility disturbances can be challenging to establish in critically ill patients. The available tests used for detection of abnormal motility have major limitations in the ICU setting. Recognition of the type and site of intestinal motility disorder is important to guide the therapy and improve the outcome.

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Section: Normal Gi Motilitymentioning

confidence: 99%

Altered GI Motility in Critically Ill Patients

Ukleja

2010

Nut in Clin Prac

107

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“…35 A second in vitro study, looking at clinically relevant higher dose and prolonged exposure, demonstrated an inhibitive effective on spontaneous muscle contractions and a concentration-dependent depression of stimulated muscle contractions in gastric fundal and descending colon muscle strips obtained from patients undergoing resection of cancers in those respective areas. 36 Propofol has a relaxing effect on visceral smooth muscle that seems to be clinically insignificant in healthy subjects. In the ICU setting, where multiple factors affect gastric emptying, this agent may contribute to delayed gastrointestinal motility.…”

Section: Changes In Gastric Motility In Critical Illnessmentioning

confidence: 99%

Physiology of the Aerodigestive System and Aberrations in That System Resulting in Aspiration

DeMeo¹,

Bruninga

2002

J Parenter Enteral Nutr

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“…in Ͼ79% of our patients; in fact, vasoactive drugs are known to induce a relative splanchnic ischemia and delay gastric emptying, 27 whereas in vitro, at clinically relevant concentrations, propofol impairs gut contractile activity. 28 Both HI and AD were significantly associated with malnutrition; edema and low serum albumin were independently associated with high VGR and AD. Undernutrition is known to influence EN tolerance because nutrient digestion and absorption are limited.…”

Section: Discussionmentioning

confidence: 91%