The Effect of Propranolol and the dextro and laevo Isomers of H 56/28 upon Ouabain‐Induced Ventricular Tachycardia in Unanaesthetized Dogs

Duce, Benjamin R.; Garberg, L; Johansson, Birgitta

doi:10.1111/j.1600-0773.1967.tb02995.x

Cited by 34 publications

(5 citation statements)

References 9 publications

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“…Therefore, the therapeutic effects of P-blocking agents against digitalis-induced arrhythmias in man are assumed to be due to 0-receptor antagonism (Fitzgerald 1975). This is contrary to ouabain-induced arrhythmias in dogs, where a P-receptor blockade did not decrease the frequency of ectopic beats (Duce et al 1967).…”

contrasting

confidence: 74%

Effects of Adrenergic P‐Blockers and a Membrane Stabilizing Agent on Ouabain‐Induced Cardiac Arrhythmias in Anaesthetized Guinea Pigs

Åberg

Adler

Duker

et al. 1979

Acta Pharmacologica et Toxicologica

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The antiarrhythmic effects of dl‐propranolol, d‐propranolol, metoprolol and lidocaine against ouabain‐induced cardiac arrhythmias were studied. It was found that contrary to earlier findings in the dog, the effects of the adrenergic β‐blockers against ouabain‐arrhythmias in guinea pigs were due to β‐blocking activity and not the membrane‐stabilizing activity of the compounds. The cardioselective β‐blocker, metoprolol, was more or equally effective as dl‐propranolol against ouabain‐induced arrhythmias in guinea pigs.

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contrasting

confidence: 74%

Effects of Adrenergic P‐Blockers and a Membrane Stabilizing Agent on Ouabain‐Induced Cardiac Arrhythmias in Anaesthetized Guinea Pigs

Åberg

Adler

Duker

et al. 1979

Acta Pharmacologica et Toxicologica

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“…In ouabain-induced ventricular tachycardia in dogs, d-alprenolol was as effective as l-alprenolol or dl-propranolol in causing reversion to sinus rhythm. 32 Yet, dralprenolol has only one hundredth the bet\blocking: activity of l-alprenoloP9 and is . significantly less cardiodepressant in dogs.…”

Section: Discussionmentioning

confidence: 99%

Human Cardiovascular Effects of Alprenolol, A Beta‐Adrenergic Blocker: Hemodynamic, Antiarrhythmic, and Antianginal

Wasserman

Proctor

Allen

et al. 1970

The Journal of Clinical Pharmacology and The Journal of New Dru

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“…If the study drug does not show a positive effect, higher doses are given 15 min apart. If the test chemical is effective in reversing the arrhythmias, the next dose is administered when a sustained arrhythmia recurs 229 , 230 .…”

Section: In Vivo Approachesmentioning

confidence: 99%

New drug discovery of cardiac anti-arrhythmic drugs: insights in animal models

Sharma,

Singh,

Bhat

et al. 2023

Sci Rep

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Cardiac rhythm regulated by micro-macroscopic structures of heart. Pacemaker abnormalities or disruptions in electrical conduction, lead to arrhythmic disorders may be benign, typical, threatening, ultimately fatal, occurs in clinical practice, patients on digitalis, anaesthesia or acute myocardial infarction. Both traditional and genetic animal models are: In-vitro: Isolated ventricular Myocytes, Guinea pig papillary muscles, Patch-Clamp Experiments, Porcine Atrial Myocytes, Guinea pig ventricular myocytes, Guinea pig papillary muscle: action potential and refractory period, Langendorff technique, Arrhythmia by acetylcholine or potassium. Acquired arrhythmia disorders: Transverse Aortic Constriction, Myocardial Ischemia, Complete Heart Block and AV Node Ablation, Chronic Tachypacing, Inflammation, Metabolic and Drug-Induced Arrhythmia. In-Vivo: Chemically induced arrhythmia: Aconitine antagonism, Digoxin-induced arrhythmia, Strophanthin/ouabain-induced arrhythmia, Adrenaline-induced arrhythmia, and Calcium-induced arrhythmia. Electrically induced arrhythmia: Ventricular fibrillation electrical threshold, Arrhythmia through programmed electrical stimulation, sudden coronary death in dogs, Exercise ventricular fibrillation. Genetic Arrhythmia: Channelopathies, Calcium Release Deficiency Syndrome, Long QT Syndrome, Short QT Syndrome, Brugada Syndrome. Genetic with Structural Heart Disease: Arrhythmogenic Right Ventricular Cardiomyopathy/Dysplasia, Dilated Cardiomyopathy, Hypertrophic Cardiomyopathy, Atrial Fibrillation, Sick Sinus Syndrome, Atrioventricular Block, Preexcitation Syndrome. Arrhythmia in Pluripotent Stem Cell Cardiomyocytes. Conclusion: Both traditional and genetic, experimental models of cardiac arrhythmias’ characteristics and significance help in development of new antiarrhythmic drugs.

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The Effect of Propranolol and the dextro and laevo Isomers of H 56/28 upon Ouabain‐Induced Ventricular Tachycardia in Unanaesthetized Dogs

Cited by 34 publications

References 9 publications

Effects of Adrenergic P‐Blockers and a Membrane Stabilizing Agent on Ouabain‐Induced Cardiac Arrhythmias in Anaesthetized Guinea Pigs

Effects of Adrenergic P‐Blockers and a Membrane Stabilizing Agent on Ouabain‐Induced Cardiac Arrhythmias in Anaesthetized Guinea Pigs

Human Cardiovascular Effects of Alprenolol, A Beta‐Adrenergic Blocker: Hemodynamic, Antiarrhythmic, and Antianginal

New drug discovery of cardiac anti-arrhythmic drugs: insights in animal models

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