The Effect of Propranolol on Blood Pressure and Sympathetic Nerve Activity in the Spontaneously Hypertensive Rats

Drinking Water and Drug Dosage in Rat Studies

“…betaadrenoceptor blocking drugsby some authors have been reported to be ineffective in the SHR, while others found treatment successful (Weiss et al 1974;Forman & Mulrow 1974;Yamori 1975;Pedersen 1979). However, until recently it was not realized that rats given propranolol in the drinking water have a lower water intake than control rats (Pfeffer et al 1977;Nishiyama et al 1978;Takeda et al 1980). This in combination with extensive first-pass effect on propranolol in the rat may explain, why such conflicting findings have been published.…”