The effect of Prosopis farcta extract on the expression of some key genes of the glycolysis pathway and the genes involved in insulin signaling in HepG2 cells

Modulation of gut microbiota and hypoglycemic/hypolipidemic activity of flavonoids from the fruits ofLycium barbarumon high-fat diet/streptozotocin-induced type 2 diabetic mice

“…46,47 Many studies have shown that the activities of GK and PFK in diabetes and diabetic animals are significantly reduced, which may have an important impact on the occurrence and development of diabetes, hence becoming a new way to treat diabetes by improving their activities. 48 In this study, the mRNA expression of GK and PFK in the diabetic treatment groups was significantly lower than that in the NC group, and the LBFs groups increased significantly. These results suggest that LBFs play an important role in the hypoglycemic effect of T2DM by promoting glycolysis, which may provide a new idea for further exploring the biological activity of LBFs.…”

“…54 It has been reported that some drugs or natural products with hypoglycemic activity are able to improve dyslipidemia caused by diabetes by regulating the expression of genes related to fatty acid synthesis and lipid metabolism. 46,48 Therefore, the expression of the key transcription factor of lipid metabolism (SREBP-1c), downstream adipogenic genes (including FAS and ACC), and nuclear receptors (PPARα and PPARγ) of regulating fatty acid oxidation were used to evaluate the effects of LBFs on the diabetes mice. The results showed that LBFs intervention could significantly reduce the gene expression of PPARγ, FAS, ACC, and SREBP-1c, which is related to fat synthesis and accumulation, and remarkably enhances the expression of PPARα, which promoted fatty-acid oxidation.…”