The Effect of Prostaglandin Analogues on Central Corneal Thickness

Abstract

• Page 1 of 6 • Uzunel. Int J Ophthalmol Clin Res 2018, 5:084 gested mechanism of IOP reduction involves aqueous humor outflow enhancement through the uveoscleral pathway accompanied by collagen degradation in the ciliary body. This collagen degradation is believed to be mediated by Matrix Metalloproteinases (MMPs) induced by prostaglandin F2-alpha [2,3]. Furthermore, because the cornea is mainly composed of collagen fiber [4], corneal thinning may be anticipated after pros-Elevated IOP is a risk factor for glaucoma and it's believed that to decrease the IOP values is the first choice of treatment in glaucoma [5]. Goldmann Applanation Tonometry (GAT) is known to be a standart method for IOP measurements however it's also well known that changes in Central Corneal Thickness (CCT) measurements may influence the GAT results accurate results of GAT are produced with a CCT of 520 mm, but CCT values higher or lower than 520 mm produces unreliable IOP measurements by over or under estimating of IOP values [6]. Besides its importance in IOP measurements it's also been suggested that CCT is an independent risk factor of progression in open angle glaucoma [7].The purpose of this study was to evaluate 5-year changes in the CCT in glaucoma patients treated with PG analogues monotherapy and to investigate the association between the CCT and the IOP in these patients. Material and MethodsMedical charts of 3696 glaucoma patients who have been followed up at Izmir Bozyaka Training and Research Hospital were reviewed retrospectively. Seventy-three eyes of 73 glaucoma patients constituted the glaucoma group and 75 eyes of 75 glaucoma-suspect patients constituted the control group. The inclusion

The Effect of Prostaglandin Analogs on Central Corneal Thickness of Patients with Glaucoma or Ocular Hypertension: A Systematic Review

“…Our subgroups based on study locations, measurement tools, and control group selection did not provide contradictory results, indicating that these limitations are unlikely to cause significant bias. Consistent and significant results were also obtained in disease subgroups, except those containing OHTSs, including the studies of Brandt et al [30] and Uzunel et al [49]. In this subgroup, the study of Brandt et al [30] accounts for the larger weighting (11.63%), potentially explaining the inconsistent result.…”

“…The main characteristics of the selected studies are presented in Table 1. These studies were performed in four regions or countries: six [33, 38, 40, 49, 52, 56] in Europe (Germany, Switzerland, Italy, Greece, and Turkey), four [34, 42, 45, 68] in Asia (South Korea and China), one [30] in the USA, one [32] in Brazil, and one [41] in Australia. Of these studies, five [30, 32, 33, 40, 52] were cohort-based, three [38, 56, 68] were cross-sectional, and five [34, 41, 42, 45, 49] were case-control studies.…”

“…These studies were performed in four regions or countries: six [33, 38, 40, 49, 52, 56] in Europe (Germany, Switzerland, Italy, Greece, and Turkey), four [34, 42, 45, 68] in Asia (South Korea and China), one [30] in the USA, one [32] in Brazil, and one [41] in Australia. Of these studies, five [30, 32, 33, 40, 52] were cohort-based, three [38, 56, 68] were cross-sectional, and five [34, 41, 42, 45, 49] were case-control studies. Four studies [33, 38, 41, 56] provided data concerning glaucoma, four [32, 40, 52, 68] focused on POAG, one [30] focused on OHT, one [49] focused on POAG and OHT, and three [34, 42, 45] on patients with normal-tension glaucoma (NTG).…”

“…Of these studies, five [30, 32, 33, 40, 52] were cohort-based, three [38, 56, 68] were cross-sectional, and five [34, 41, 42, 45, 49] were case-control studies. Four studies [33, 38, 41, 56] provided data concerning glaucoma, four [32, 40, 52, 68] focused on POAG, one [30] focused on OHT, one [49] focused on POAG and OHT, and three [34, 42, 45] on patients with normal-tension glaucoma (NTG).…”

“…There are also conflicting findings regarding the effect of BAK on CCT. A decrease in corneal epithelial layers with a highly significant decrease in the CTT following Ophthalmic Res 2023;66:431-444 DOI: 10.1159/000528461 long-term treatment with BAK-containing eye drops was reported [49,[81][82][83]. However, a cohort study by Rossi et al [57] found that CCT did not significantly change in the preservative-free group, preservative group, and healthy control group after a 12-month follow-up.…”