The effect of prostaglandin F2α administration at the time of insemination on the pregnancy rate of dairy cows

Gabriel, H.G.; Wallenhorst, S.; Dietrich, Eva-Maria; Holtz, W.

doi:10.1016/j.anireprosci.2010.11.010

Cited by 16 publications

(15 citation statements)

References 37 publications

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“…Cow fertility declines with increased age as stresses associated with calving, lactation and clinical abnormalities at parturition or postpartum have a negative effect on fertility [34,35]. Previous studies have found that heifers had a higher NRR compared to multiparous dairy cows [36,37]. The results of the current study show that, while numerically greater, CR of heifers did not differ to primiparous dairy cows but was ~13% higher than multiparous dairy cows with a parity of greater than 5.…”

Section: Accepted Manuscriptcontrasting

confidence: 39%

Effect of storage temperature, nitrogen gassing and sperm concentration on the in vitro semen quality and in vivo fertility of liquid bull semen stored in INRA96

et al. 2018

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The aim of this study was to assess the effect of storage temperature, nitrogen (N) gassing and sperm concentration on in vitro characteristics and calving rate (CR) following artificial insemination (AI) of liquid bull semen stored in INRA96. In Experiment 1 the effect of liquid bull semen diluted in either N bubbled or non-bubbled INRA96 at a concentration of 5 × 10 sperm per 0.25 mL insemination dose and stored at 5 or 15 °C was assessed subjectively for total and progressive motility on Days 0, 1, 2, 3 and 4 post collection. In Experiment 2a, the effect of stored liquid semen at three sperm concentrations (3, 4 or 5 × 10 sperm per 0.25 mL insemination dose) on total and progressive motility was assessed subjectively on Days 0, 1 and 2 post collection. In Experiment 2b, the field fertility of liquid semen stored at ambient temperature at a concentration of 3, 4 or 5 × 10 sperm per 0.25 mL dose and inseminated on Days 1 or 2 post collection was assessed in comparison to frozen-thawed semen (total of n = 5742). In Experiment 1, total and progressive motility decreased with increased duration of storage (P < 0.01); however, there was no effect of N bubbling on motility on Days 0, 1, 2, 3 and 4 of storage. There was an effect of temperature on total and progressive motility, regardless of treatment, as semen stored at 15°C recorded higher motility values than semen stored at 5°C (P < 0.01). In Experiment 2a, there was no effect of sperm concentration on total or progressive motility on Days 0, 1 or 2 of storage. There was a linear decrease in motility with increased duration of storage (P < 0.01); however, there was no sperm concentration by day interaction. In Experiment 2b, there was an effect of sperm concentration on CR (P < 0.01); semen diluted to 3 and 4 × 10 sperm per dose resulted in a lower CR after 2 days of storage (41.1 and 44.7%, respectively) in comparison to frozen-thawed semen (55.2%) but did not differ to CR of semen diluted to 5 × 10 sperm per dose on Day 2 of storage. There was an effect of parity, fertility sub-index and days in milk (DIM) at AI on CR (P < 0.01). In conclusion, N bubbling and sperm concentration had no effect on in vitro sperm motility of liquid semen, but this study demonstrated a reduction in CR on Day 2 of storage at lower sperm concentrations in comparison to frozen-thawed semen.

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Section: Accepted Manuscriptcontrasting

confidence: 39%

Effect of storage temperature, nitrogen gassing and sperm concentration on the in vitro semen quality and in vivo fertility of liquid bull semen stored in INRA96

et al. 2018

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“…The prostanoid prostaglandin F2a (PGF), derived from arachidonic acid, is a biologically potent substance with several applications in the control of reproduction. In cattle, the most common uses are estrus synchronization, regression of persistent CL, and induction of abortion or parturition [2] due to its luteolytic properties. PGF is widely used alone to induce luteolysis and estrus, however, PGF is also used associated to intravaginal progesterone device and estradiol esters in beef cows subjected to timed artificial insemination (TAI) protocols.…”

Section: Introductionmentioning

confidence: 99%

Different protocols using PGF2α as ovulation inducer in Nelore cows subjected to estradiol-progesterone timed AI based protocols

et al. 2018

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The objective of this study was to evaluate the effect of a PGFα-analogue (PGF) on ovulation and pregnancy rates after timed artificial insemination (TAI) in cattle. In Experiment 1 cows received an intravaginal progesterone-releasing device (CIDR) plus 2 mg im of estradiol benzoate (EB) on Day 0. The CIDR devices were removed on Day 8, and all cows received 150 μg im of d-cloprostenol (PGFα-analogue), 300 IU of eCG and 1 mg of estradiol cypionate (ECP) im. On Day 9, cows were randomly assigned into two groups: 1) ECP Group (n = 17), that did not receive any further treatment; and 2) ECP-PG Group (n = 14) that were given 150 μg of d-cloprostenol (PGF) as adjuvant stimulus for ovulation. No difference between groups was detected in interval for ovulation (P = 0.5), and in the proportion of cows ovulating (P = 0.09). In Experiment 2, multiparous suckling crossbred Aberdeen Angus cows (n = 260), were treated into two groups, similarly as Experiment 1; ECP group (n = 122), and ECP-PG group (n = 138). All females were TAI on Day 10. The proportion of cows treated with ECP that became pregnant was 54.9% (67/122), and cows treated with ECP plus PGF was 55.1% (76/138; P = 0.9). In Experiment 3, 686 Nelore cows, 40 to 50 days postpartum, were treated as Experiment 1 (ECP group), however, on Day 8 cows were divided into 3 groups: ECP Group (n = 216); PGF-SC Group (n = 228), in which cows did not receive ECP and were given an additional subcutaneous injection of PGF on Day 8; and PGF-IM Group (n = 242), in which cows also did not receive ECP on Day 8 and were given an additional injection of PGF im on Day 9. On Day 10, estrus was evaluated at timed AI (TAI). There was no difference in the diameter of the dominant follicle at CIDR removal and at TAI, and pregnancy per AI among groups (P > 0.05). However, the proportion of cows that displayed estrus between CIDR removal and TAI was higher in ECP group than in PGF-SC and PGF-IM groups (P < 0.001). Cows that displayed estrus has higher P/AI than cows that did not (P = 0.008). In conclusion, these results suggested that intramuscular or subcutaneous injection of PGFα could be successfully used to induce ovulation in cattle undergoing TAI, with similar pregnancy rates when compared with ECP. The subcutaneous injection of PGF on the same day of CIDR removal could be an interesting alternative due it reduces cattle management to obtain similar results.

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“…The mechanism by which PGF may affect fertility, when it is used in TAI protocols, could act either by anticipating luteolysis (Bisinotto et al, 2010;Santos et al, 2010;Lima et al, 2013), or by improving uterine environment for early conception development (Neglia et al, 2008;Gabriel et al, 2011;Garcia-Ispierto & Lópes-Gatius, 2014;Ambrose et al, 2015). Furthermore, incomplete luteolysis has been reported as a negative factor that impairs fertility of a TAI protocol .…”

Section: Introductionmentioning

confidence: 99%

Prostaglandin F2α or estradiol benzoate to induce ovulation in timed artificially inseminated dairy cows

Pfeifer

Siqueira

Arashiro

et al. 2016

Pesq. agropec. bras.

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-The objective of this work was to compare two types of ovulation inducers -estradiol benzoate (EB group) or prostaglandin F2α (PG group) -, in postpartum dairy cows subjected to timed artificial insemination (TAI). Lactating Holstein-Gir crossbred cows (n=118) with 60 to 120 days of milk production were used in this study. All cows were treated with an intravaginal progesterone-releasing device (CIDR) plus 2 mg of estradiol benzoate (EB) on day 0. The CIDR inserts were removed on day 9, and all cows received 500 µg sodium cloprostenol. Twenty-four hours after CIDR removal, cows were randomly assigned into two treatment groups and were given either 1 mg of EB i.m. (EB group) or 500 µg sodium cloprostenol i.m. (PG group). TAI were performed at 52 to 54 hours, in both EB and PG groups, after CIDR removal. No differences were observed in the ovulation (85.2% vs 72.7%) and pregnancy rates (40.7% vs 38.2%) between the EB and PG groups, respectively. Fertility is similar in the TAI protocols that use prostaglandin F2α or EB to induce ovulation in lactating dairy cows.Index terms: artificial insemination, cattle, estrus, synchronization, withdrawal period. Prostaglandina F2α ou benzoato de estradiol para induzir a ovulação em vacas leiteiras inseminadas em tempo fixoResumo -O objetivo deste trabalho foi comparar dois indutores de ovulação -benzoato de estradiol (grupo BE) ou prostaglandina F2α (grupo PG) -, em vacas leiteiras pós-parto submetidas à inseminação artificial em tempo fixo (IATF). Neste estudo, utilizaram-se vacas Girolando lactantes (n=118) com 60 a 120 dias em lactação. Todas as vacas foram tratadas com um implante intravaginal liberador de progesterona (CIDR) associado a 2 mg de benzoato de estradiol (BE) no dia 0. O CIDR foi retirado no dia 9, e todas as vacas receberam 500 µg i.m. de cloprostenol sódico (análogo à prostaglandina F2α Termos para indexação: inseminação artificial, bovinos, estro, sincronização, período de carência.

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The effect of prostaglandin F2α administration at the time of insemination on the pregnancy rate of dairy cows

Cited by 16 publications

References 37 publications

Effect of storage temperature, nitrogen gassing and sperm concentration on the in vitro semen quality and in vivo fertility of liquid bull semen stored in INRA96

Effect of storage temperature, nitrogen gassing and sperm concentration on the in vitro semen quality and in vivo fertility of liquid bull semen stored in INRA96

Different protocols using PGF2α as ovulation inducer in Nelore cows subjected to estradiol-progesterone timed AI based protocols

Prostaglandin F2α or estradiol benzoate to induce ovulation in timed artificially inseminated dairy cows

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