The effect of protease inhibitors derived from potato formulated in a minidrink on appetite, food intake and plasma cholecystokinin levels in humans

Peters, H. P. F.; Foltz, Martin; Kovács, Éva; Mela, David J.; Schuring, Ewoud A.H.; Wiseman, Sheila A.

doi:10.1038/ijo.2010.136

Cited by 22 publications

(10 citation statements)

References 17 publications

(23 reference statements)

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“…The highest dosage of SLD used was 300 mg/kg. In previous clinical and in vivo studies (25,26), which employed ~15 mg/kg PPI II, satiety response and anti-obesity effects were observed.…”

Section: Introductionmentioning

confidence: 98%

Anti-obesity and anti-diabetic effects of a standardized potato extract in ob/ob mice

Sung²,

Choung³

et al. 2016

Experimental and Therapeutic Medicine

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Abstract. The potato (Solanum tuberosum) has been cultivated globally for food for millenia. Potato contains proteinase inhibitor II, which catalyzes the release of cholecystokinin (CCK), leading to delayed gastric emptying in humans. The present study investigated the anti-obesity effects of Slendesta™ Potato Extract (SLD), a standardized potato extract containing 5% proteinase inhibitor II, in the ob/ob obese mice. Three doses of SLD (50, 150 or 300 mg/kg) were orally administered to ob/ob mice once a day for 28 days, whereas control mice were administered distilled water. Four weeks after SLD treatment, the changes in body weight, food consumption, epididymal fat weight, serum chemistry, insulin, leptin and adiponectin contents, and fat histopathology were determined and compared with ob/ob mice treated with 750 mg/kg conjugate linoleic acid. As a result of SLD treatment in the obese mice, body weight, food consumption, epididymal fat, serum biochemistry, histomorphological changes of fat and pancreas were significantly and dose-dependently decreased compared with ob/ob control mice. These obesity and type 2 diabetes associated alterations were significantly inhibited after SLD treatment for 28 days. Thus, the present results indicate that SLD has potential as an alternative therapeutic agent for obesity.

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“…The highest dosage of SLD used was 300 mg/kg. In previous clinical and in vivo studies (25,26), which employed ~15 mg/kg PPI II, satiety response and anti-obesity effects were observed.…”

Section: Introductionmentioning

confidence: 98%

Anti-obesity and anti-diabetic effects of a standardized potato extract in ob/ob mice

Sung²,

Choung³

et al. 2016

Experimental and Therapeutic Medicine

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“…Indeed, the consumption of 1.5 g of PI2 in a high-protein soup vehicle results in increased CCK levels and decreased energy intake in human subjects (65). However, when only 30 mg of PI2 is consumed in a minidrink, no such differences in appetite, food intake, and plasma CCK and glucose levels were observed (67). These studies suggest that large amounts of PI2 are needed to have physiological effects.…”

Section: Potatoesmentioning

confidence: 94%

White Vegetables: Glycemia and Satiety

Anderson

Soeandy

Smith

2013

Advances in Nutrition

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The objective of this review is to discuss the effect of white vegetable consumption on glycemia, satiety, and food intake. White vegetables is a term used to refer to vegetables that are white or near white in color and include potatoes, cauliflowers, turnips, onions, parsnips, white corn, kohlrabi, and mushrooms (technically fungi but generally considered a vegetable). They vary greatly in their contribution to the energy and nutrient content of the diet and glycemia and satiety. As with other foods, the glycemic effect of many white vegetables has been measured. The results illustrate that interpretation of the semiquantitative comparative ratings of white vegetables as derived by the glycemic index must be context dependent. As illustrated by using the potato as an example, the glycemic index of white vegetables can be misleading if not interpreted in the context of the overall contribution that the white vegetable makes to the carbohydrate and nutrient composition of the diet and their functionality in satiety and metabolic control within usual meals. It is concluded that application of the glycemic index in isolation to judge the role of white vegetables in the diet and, specifically in the case of potato as consumed in ad libitum meals, has led to premature and possibly counterproductive dietary guidance.

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“…Worse, to date most of the agents proposed or currently sold as "functional" food ingredients for appetite control appear to lack consistent support for efficacy, or are unsuitable or ineffective in desired food formats (Wiseman et al, 2008;Keogh et al, 2010;Appleton et al, 2011;Smit et al, 2011;Blom et al, 2011;Peters et al, 2009Peters et al, , 2011aVerhoef and Westerterp, 2011;Chan et al, 2012;Márquez et al, 2012). The market potential for such (proprietary) solutions makes them highly attractive, but the costs and time needed for developing ingredients that are truly novel (in terms of source, chemistry, or biological target) and which can be brought to market with regulatory approval and substantiated claims, are barriers to commercial investment and feasibility.…”

Section: Current Status Of "Functional" Approaches To Satietymentioning

confidence: 99%

Applying Structuring Approaches for Satiety

Mela

Boland

2014

Food Structures, Digestion and Health

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The effect of protease inhibitors derived from potato formulated in a minidrink on appetite, food intake and plasma cholecystokinin levels in humans

Abstract: In this study protease inhibition using PI2 in a minidrink at a dose of 30 mg, as commercially used, had no (functional) efficacy on a range of behavioral and physiological appetite and intake control measures.

Cited by 22 publications

References 17 publications

Anti-obesity and anti-diabetic effects of a standardized potato extract in ob/ob mice

Anti-obesity and anti-diabetic effects of a standardized potato extract in ob/ob mice

White Vegetables: Glycemia and Satiety

Applying Structuring Approaches for Satiety

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