The Effect of Protracted Tetracycline Treatment on Bone Growth and Maturation

Dj, Simmons; Sl, Chang; Je, Russell; Grazman, Brent; Webster, David; Oloff, Clarence M

doi:10.1097/00003086-198311000-00029

Cited by 7 publications

(8 citation statements)

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“…The concept that minocycline therapy can disrupt normal bone metabolism is indirectly supported by prior work showing that other tetracycline class drugs impair physiologic bone metabolism and skeletal homeostasis. 86 Simmons et al (1983) investigated the impact of a oneyear course of systemic tetracycline therapy on mandibular bone in mature female rhesus monkeys (50 mg/ kg/day). Tetracycline administration disrupted bone remodeling and dysregulated the calcium to inorganic phosphorus ratio in the mandible.…”

Section: Discussionmentioning

confidence: 99%

Antimicrobial‐induced oral dysbiosis exacerbates naturally occurring alveolar bone loss

et al. 2021

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Periodontitis-mediated alveolar bone loss is caused by dysbiotic shifts in the commensal oral microbiota that upregulate proinflammatory osteoimmune responses.The study purpose was to determine whether antimicrobial-induced disruption of the commensal microbiota has deleterious effects on alveolar bone. We administered an antibiotic cocktail, minocycline, or vehicle-control to sex-matched C57BL/6T mice from age 6-to 12 weeks. Antibiotic cocktail and minocycline had catabolic effects on alveolar bone in specific-pathogen-free (SPF) mice. We then administered minocycline or vehicle-control to male mice reared under SPF and germ-free conditions, and we subjected minocycline-treated SPF mice to chlorhexidine oral antiseptic rinses. Alveolar bone loss was greater in vehicle-treated SPF versus germ-free mice, demonstrating that the commensal microbiota drives naturally occurring alveolar bone loss. Minocycline-versus vehicle-treated germfree mice had similar alveolar bone loss outcomes, implying that antimicrobialdriven alveolar bone loss is microbiota dependent. Minocycline induced phylum-level shifts in the oral bacteriome and exacerbated naturally occurring

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Section: Discussionmentioning

confidence: 99%

Antimicrobial‐induced oral dysbiosis exacerbates naturally occurring alveolar bone loss

et al. 2021

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“…Orale toediening van tetracycline bij jonge makaken leidde tot een vertraging van de enchondrale ossificatie en lineaire groei van botten (Pritzker et al, 2012). Bij een langdurige studie op volwassen makaken met dagelijkse intramusculaire injectie van tetracycline werd irreversibele botschade teweeggebracht door verminderde botremodellering en botmineralisatie (Simmons et al, 1983;Pritzker et al, 2012).…”

Section: Tetracyclineunclassified

Botpathologie bij apen van de Nieuwe en Oude Wereld

Molenberghs¹,

Chiers²,

Bakker³

et al. 2015

Vlaams Diergeneeskundig Tijdschrift

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Primaten worden vaak gebruikt als diermodel in het biomedisch onderzoek wegens hun sterke overeenkomsten met de mens. Voornamelijk penseelapen (Callithrix jacchus) en resusapen (Macaca mulatta) zijn frequent gebruikte apensoorten in het wetenschappelijk onderzoek. In dit artikel wordt een systematisch overzicht gegeven van de belangrijkste botaandoeningen bij primaten. Botaandoeningen kunnen spontaan voorkomen maar ook experimenteel worden geïnduceerd in het kader van onderzoek naar humane ziekten. Een gedegen kennis van deze pathologieën is niet enkel belangrijk om preventieve of therapeutische interventies te onderbouwen bij zowel de aap als de mens, maar draagt ook bij tot een optimale keuze van het diermodel. De, voornamelijk historisch gezien, belangrijkste groep van aandoeningen die hier worden besproken zijn de metabole aandoeningen, waarbij de nadruk ligt op rachitis/osteomalacie en osteoporose. Congenitale aandoeningen, ontwikkelingsstoornissen, intoxicaties en deficiënties met effect op het skelet worden ook besproken. Tenslotte zijn er nog de bottumoren, die weliswaar minder frequent gerapporteerd worden, maar die toch een niet te verwaarlozen groep vormen.

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“…31 It was also shown to slow bone maturation in monkeys. 47 In humans, it has caused a reversible 40% reduction of fibular growth in premature children. 32 Because tetracycline seems to be problematic mostly in growing bones and teeth, tissues already mineralized should not be affected and should not become fluorescent green when exposed to tetracycline, unless new mineralization occurs.…”

Section: Tetracyclinementioning

confidence: 99%

Green Bone

Boulos¹

2007

Arch Ophthalmol

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Todescribetheunusualfindingofyellow-greencolored bone during routine orbital surgery, to detail its investigation, and to demonstrate its benign nature. Methods: When green bone was found, specimens were sent for light and fluorescent microscopy, ultraviolet photography, and spectrophotometry. Results: Yellow-green bone was encountered in 3 patients during orbital tumor excision or orbital fracture repair procedures. The only common cause was prior use of tetracycline during adolescence. All patients had healthy white dentition. In all cases, absence of neoplasia was demonstrated histologically. The bone fluoresced with a bright yellow-green color when exposed to 365-nm ultraviolet light. Histologic analysis demonstrated fluorescence located near the haversian canals. Spectrophotometry revealed absorption at 4 wavelengths specific to tetracycline: 230, 275, 380, and 440 nm. Conclusions: Fixation of tetracycline and ensuing fluorescence occurs mostly in areas of new bone growth and mineralization. This happens during childhood but also with bone remodeling associated with tumors or fractures. Once mineralized, teeth should therefore not be affected if tetracycline exposure occurs after ages 8 to 10 years. This paucity of external clues can lead to the surprising but innocuous surgical finding of green bone. Careful history and proper investigation can confirm its origin.

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The Effect of Protracted Tetracycline Treatment on Bone Growth and Maturation

Cited by 7 publications

References 0 publications

Antimicrobial‐induced oral dysbiosis exacerbates naturally occurring alveolar bone loss

Antimicrobial‐induced oral dysbiosis exacerbates naturally occurring alveolar bone loss

Botpathologie bij apen van de Nieuwe en Oude Wereld

Green Bone

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