The Effect of Psychological Distress on Medication Adherence in Persons With HIV Infection in Nigeria

Adewuya, Abiodun O.; Afolabi, Mohammed O.; Ola, Bolanle; Ogundele, Olorunfemi Akinbode; Ajibare, Adeola O.; Oladipo, Bamidele F.; Fakande, Ibiyemi

doi:10.1016/s0033-3182(10)70661-7

Cited by 26 publications

(10 citation statements)

References 18 publications

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“…This study found the rate of poor adherence to HAART to be 36.8%. This is slightly higher than reported prevalence rate of poor adherence to ART found in previous studies [18,22]. Studies conducted in more developed countries report better adherence to ART, and may reflect better awareness of the benefits of HAART as well as fewer logistic constraints, unlike in developing countries where transport problems, lack of funds to access healthcare services, or treatment payment for co-morbid illness [39].…”

Section: Prevalence Of Poor Adherence To Highly Active Antiretroviral Therapymentioning

confidence: 57%

“…Poor adherence to antiretroviral therapy (ART) is associated with failure to prevent viral replication, increased likelihood of developing viral resistance, development of clinical complications, and reduced life expectancy [16,17]. In addition, psychiatric morbidity worsens adherence to highly active antiretroviral therapy (HAART) amongst PLWHA [18][19][20][21][22].…”

Section: Methodsmentioning

confidence: 99%

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Mood and anxiety disorders adversely influence medication adherence to antiretroviral therapy among people living with HIV/AIDS in Nigeria

Seb-Akahomen¹,

Lawani²,

James³

2018

HIV & AIDS Review

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Introduction: Psychological disorders in HIV/AIDS are well documented. However, studies enumerating its impact on medication adherence are scanty in developing countries. This study sought to determine the collective impact of mood and anxiety disorders on medication adherence among persons living with HIV/AIDS (PLWHA), receiving care at a secondary health care facility in Benin-City, Nigeria. Material and methods:A cross-sectional descriptive study of 410 PLWHA was conducted between April and August 2015. A semi-structured socio-demographic and clinical history study questionnaire, the 8-item Morisky medication adherence scale (MMAS-8) to determine medication adherence to highly active antiretroviral therapy (HAART), and the mini international neuropsychiatric interview (MINI) to diagnose mood and anxiety disorders were administered to participants.Results: One hundred and fifty-one participants (36.8%) were poorly adherent to their medications, with nearly 1 in 3 (31.5%) diagnosed with a mood or anxiety disorder. On bivariate analysis, poor medication adherence was significantly associated with low (< 200 cell/mm 3 ) CD4 cell count (crude OR = 3.23; 95% CI: 1.81-5.80; p < 0.001) and having a mood or anxiety disorder (crude OR = 17.89; 95% CI: 10.28-31.38; p < 0.001). The presence of a mood/anxiety disorder predicted poor adherence (AOR = 16.45; 95% CI: 9.69-27.92; p < 0.001) on multivariate analysis.Conclussions: Mood and anxiety disorders in PLWHA are common and are associated with poorer medication adherence. Further research is required to assess if screening and management of mood and anxiety disorders would improve medication adherence.

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Section: Prevalence Of Poor Adherence To Highly Active Antiretroviral Therapymentioning

confidence: 57%

Section: Methodsmentioning

confidence: 99%

Mood and anxiety disorders adversely influence medication adherence to antiretroviral therapy among people living with HIV/AIDS in Nigeria

Seb-Akahomen¹,

Lawani²,

James³

2018

HIV & AIDS Review

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“…In total, 207 studies were included in our analysis, reporting on 103,836 patients [16]-[222]. Two hundred studies consisted of one independent sample for calculating effect sizes, five studies consisted of two samples and two studies consisted of three samples, resulting in a total of 216 independent samples (k = 216).…”

Section: Resultsmentioning

confidence: 99%

Predictors and correlates of adherence to combination antiretroviral therapy (ART) for chronic HIV infection: a meta-analysis

Langebeek

Gisolf

Reiss

et al. 2014

BMC Med

359

132

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BackgroundAdherence to combination antiretroviral therapy (ART) is a key predictor of the success of human immunodeficiency virus (HIV) treatment, and is potentially amenable to intervention. Insight into predictors or correlates of non-adherence to ART may help guide targets for the development of adherence-enhancing interventions. Our objective was to review evidence on predictors/correlates of adherence to ART, and to aggregate findings into quantitative estimates of their impact on adherence.MethodsWe searched PubMed for original English-language papers, published between 1996 and June 2014, and the reference lists of all relevant articles found. Studies reporting on predictors/correlates of adherence of adults prescribed ART for chronic HIV infection were included without restriction to adherence assessment method, study design or geographical location. Two researchers independently extracted the data from the same papers. Random effects models with inverse variance weights were used to aggregate findings into pooled effects estimates with 95% confidence intervals. The standardized mean difference (SMD) was used as the common effect size. The impact of study design features (adherence assessment method, study design, and the United Nations Human Development Index (HDI) of the country in which the study was set) was investigated using categorical mixed effects meta-regression.ResultsIn total, 207 studies were included. The following predictors/correlates were most strongly associated with adherence: adherence self-efficacy (SMD = 0.603, P = 0.001), current substance use (SMD = -0.395, P = 0.001), concerns about ART (SMD = -0.388, P = 0.001), beliefs about the necessity/utility of ART (SMD = 0.357, P = 0.001), trust/satisfaction with the HIV care provider (SMD = 0.377, P = 0.001), depressive symptoms (SMD = -0.305, P = 0.001), stigma about HIV (SMD = -0.282, P = 0.001), and social support (SMD = 0.237, P = 0.001). Smaller but significant associations were observed for the following being prescribed a protease inhibitor-containing regimen (SMD = -0.196, P = 0.001), daily dosing frequency (SMD = -0.193, P = 0.001), financial constraints (SMD -0.187, P = 0.001) and pill burden (SMD = -0.124, P = 0.001). Higher trust/satisfaction with the HIV care provider, a lower daily dosing frequency, and fewer depressive symptoms were more strongly related with higher adherence in low and medium HDI countries than in high HDI countries.ConclusionsThese findings suggest that adherence-enhancing interventions should particularly target psychological factors such as self-efficacy and concerns/beliefs about the efficacy and safety of ART. Moreover, these findings suggest that simplification of regimens might have smaller but significant effects.Electronic supplementary materialThe online version of this article (doi:10.1186/s12916-014-0142-1) contains supplementary material, which is available to authorized users.

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“…Empirical evidence shows that perceived social support has helped build up resilience against disaster or catastrophic events, and exerts its protective function on alleviating psychological distress [50]. Furthermore, social support has been found to correlate positively with compliance in patient populations [51].…”

Section: Background and Research Questionsmentioning

confidence: 99%

Stress and worry in the 2020 coronavirus pandemic: relationships to trust and compliance with preventive measures across 48 countries in the COVIDiSTRESS global survey

et al. 2021

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The COVIDiSTRESS global survey collects data on early human responses to the 2020 COVID-19 pandemic from 173 429 respondents in 48 countries. The open science study was co-designed by an international consortium of researchers to investigate how psychological responses differ across countries and cultures, and how this has impacted behaviour, coping and trust in government efforts to slow the spread of the virus. Starting in March 2020, COVIDiSTRESS leveraged the convenience of unpaid online recruitment to generate public data. The objective of the present analysis is to understand relationships between psychological responses in the early months of global coronavirus restrictions and help understand how different government measures succeed or fail in changing public behaviour. There were variations between and within countries. Although Western Europeans registered as more concerned over COVID-19, more stressed, and having slightly more trust in the governments' efforts, there was no clear geographical pattern in compliance with behavioural measures. Detailed plots illustrating between-countries differences are provided. Using both traditional and Bayesian analyses, we found that individuals who worried about getting sick worked harder to protect themselves and others. However, concern about the coronavirus itself did not account for all of the variances in experienced stress during the early months of COVID-19 restrictions. More alarmingly, such stress was associated with less compliance. Further, those most concerned over the coronavirus trusted in government measures primarily where policies were strict. While concern over a disease is a source of mental distress, other factors including strictness of protective measures, social support and personal lockdown conditions must also be taken into consideration to fully appreciate the psychological impact of COVID-19 and to understand why some people fail to follow behavioural guidelines intended to protect themselves and others from infection. The Stage 1 manuscript associated with this submission received in-principle acceptance (IPA) on 18 May 2020. Following IPA, the accepted Stage 1 version of the manuscript was preregistered on the Open Science Framework at https://osf.io/g2t3b. This preregistration was performed prior to data analysis.

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The Effect of Psychological Distress on Medication Adherence in Persons With HIV Infection in Nigeria

Cited by 26 publications

References 18 publications

Mood and anxiety disorders adversely influence medication adherence to antiretroviral therapy among people living with HIV/AIDS in Nigeria

Mood and anxiety disorders adversely influence medication adherence to antiretroviral therapy among people living with HIV/AIDS in Nigeria

Predictors and correlates of adherence to combination antiretroviral therapy (ART) for chronic HIV infection: a meta-analysis

Stress and worry in the 2020 coronavirus pandemic: relationships to trust and compliance with preventive measures across 48 countries in the COVIDiSTRESS global survey

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